This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Flo... See more...

Aliases for SRCAP Gene

Aliases for SRCAP Gene

  • Snf2 Related CREBBP Activator Protein 2 3 5
  • Domino Homolog 2 3 4
  • Helicase SRCAP 3 4
  • Swi2/Snf2-Related ATPase Homolog, Domino Homolog 1 3
  • Swi2/Snf2-Related ATPase Homolog (S. Cerevisiae) 2
  • Snf2-Related CREBBP Activator Protein 2
  • Snf2-Related CBP Activator Protein 3
  • Domino Homolog 1 (Drosophila) 2
  • Snf2-Related CBP Activator 4
  • EC 3.6.4.- 4
  • KIAA0309 4
  • EC 3.6.1 52
  • DOMO1 3
  • EAF1 3
  • FLHS 3
  • SWR1 3

External Ids for SRCAP Gene

Previous GeneCards Identifiers for SRCAP Gene

  • GC16P030002
  • GC16P031203
  • GC16P030715
  • GC16P030754
  • GC16P030748
  • GC16P030622
  • GC16P030710
  • GC16P028273

Summaries for SRCAP Gene

Entrez Gene Summary for SRCAP Gene

  • This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

GeneCards Summary for SRCAP Gene

SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Chromosome 16P13.3 Deletion Syndrome, Proximal. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.

UniProtKB/Swiss-Prot Summary for SRCAP Gene

  • Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

Gene Wiki entry for SRCAP Gene

Additional gene information for SRCAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRCAP Gene

Genomics for SRCAP Gene

GeneHancer (GH) Regulatory Elements for SRCAP Gene

Promoters and enhancers for SRCAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRCAP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRCAP

Top Transcription factor binding sites by QIAGEN in the SRCAP gene promoter:
  • AhR
  • AML1a
  • ATF
  • c-Myb
  • C/EBPalpha
  • CREB
  • deltaCREB
  • HEN1
  • Pax-4a
  • Zic1

Genomic Locations for SRCAP Gene

Genomic Locations for SRCAP Gene
chr16:30,698,209-30,741,409
(GRCh38/hg38)
Size:
43,201 bases
Orientation:
Plus strand
chr16:30,709,530-30,755,602
(GRCh37/hg19)
Size:
46,073 bases
Orientation:
Plus strand

Genomic View for SRCAP Gene

Genes around SRCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRCAP Gene

Proteins for SRCAP Gene

  • Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRS2-SRCAP_HUMAN
    Recommended name:
    Helicase SRCAP
    Protein Accession:
    Q6ZRS2
    Secondary Accessions:
    • B0JZA6
    • O15026
    • Q7Z744
    • Q9Y5L9

    Protein attributes for SRCAP Gene

    Size:
    3230 amino acids
    Molecular mass:
    343555 Da
    Quaternary structure:
    • Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
    • (Microbial infection) Interacts with hepatitis C virus (HCV) NS5A.
    • (Microbial infection) Interacts with human adenovirus 2 DBP.
    SequenceCaution:
    • Sequence=AAI59100.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRCAP Gene

    Alternative splice isoforms for SRCAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRCAP Gene

Selected DME Specific Peptides for SRCAP Gene

Q6ZRS2:
  • DEMGLGKT
  • NLTGADTV
  • RKVCNHP
  • TGTPLQN
  • HRIGQTRDVHIYR
  • GHRVLIF
  • MGLGKTIQ
  • FYDSDWNP
  • HLIIVPTSV
  • RCHRIGQ
  • NGILADE
  • LHKVLRP

Post-translational modifications for SRCAP Gene

  • Glycosylation at Ser2416
  • Ubiquitination at Lys752
  • Modification sites at PhosphoSitePlus

Other Protein References for SRCAP Gene

Domains & Families for SRCAP Gene

Gene Families for SRCAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for SRCAP Gene

Blocks:
  • SNF2 related domain
  • HSA
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRCAP Gene

GenScript: Design optimal peptide antigens:
  • SRCAP protein (Q6P4A2_HUMAN)
  • Snf2-related CBP activator (SRCAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZRS2

UniProtKB/Swiss-Prot:

SRCAP_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Family:
  • Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
genes like me logo Genes that share domains with SRCAP: view

Function for SRCAP Gene

Molecular function for SRCAP Gene

UniProtKB/Swiss-Prot Function:
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=66 uM for ATP {ECO:0000269 PubMed:10347196};

Enzyme Numbers (IUBMB) for SRCAP Gene

Phenotypes From GWAS Catalog for SRCAP Gene

Gene Ontology (GO) - Molecular Function for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10347196
GO:0004386 helicase activity IEA --
GO:0004402 histone acetyltransferase activity TAS 10347196
GO:0005515 protein binding IPI 10702287
genes like me logo Genes that share ontologies with SRCAP: view
genes like me logo Genes that share phenotypes with SRCAP: view

Human Phenotype Ontology for SRCAP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for SRCAP Gene

miRTarBase miRNAs that target SRCAP

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SRCAP Gene

Localization for SRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRCAP gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IBA 21873635
GO:0005634 nucleus IDA 10702287
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SRCAP: view

Pathways & Interactions for SRCAP Gene

PathCards logo

SuperPathways for SRCAP Gene

genes like me logo Genes that share pathways with SRCAP: view

Pathways by source for SRCAP Gene

1 BioSystems pathway for SRCAP Gene

SIGNOR curated interactions for SRCAP Gene

Activates:

Gene Ontology (GO) - Biological Process for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II TAS 10347196
GO:0016032 viral process IEA --
GO:0016458 gene silencing IBA 21873635
genes like me logo Genes that share ontologies with SRCAP: view

Drugs & Compounds for SRCAP Gene

No Compound Related Data Available

Transcripts for SRCAP Gene

mRNA/cDNA for SRCAP Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRCAP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SRCAP Gene

GeneLoc Exon Structure for
SRCAP

Expression for SRCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRCAP Gene

Protein differential expression in normal tissues from HIPED for SRCAP Gene

This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCAP Gene



Protein tissue co-expression partners for SRCAP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRCAP

SOURCE GeneReport for Unigene cluster for SRCAP Gene:

Hs.620916

Evidence on tissue expression from TISSUES for SRCAP Gene

  • Nervous system(4.7)
  • Eye(3.1)
  • Intestine(2.5)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCAP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with SRCAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene

Orthologs for SRCAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRCAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRCAP 31 30
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SRCAP 31 30
  • 91.02 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srcap 17 31 31 30
  • 87.43 (n)
dog
(Canis familiaris)
Mammalia SRCAP 31 30
  • 87.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srcap 30
  • 85.21 (n)
oppossum
(Monodelphis domestica)
Mammalia SRCAP 31
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRCAP 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15976 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15109 30
zebrafish
(Danio rerio)
Actinopterygii srcap 31
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dom 31 32
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y111B2A.23 32
  • 53 (a)
ssl-1 31
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWR1 33 31
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Cin.10052 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10052 30
Species where no ortholog for SRCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRCAP Gene

ENSEMBL:
Gene Tree for SRCAP (if available)
TreeFam:
Gene Tree for SRCAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRCAP: view image

Paralogs for SRCAP Gene