Free for academic non-profit institutions. Other users need a Commercial license
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SRC include Thrombocytopenia 6 and Myelofibrosis. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is YES1.
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | TAS | -- |
GO:0004713 | protein tyrosine kinase activity | NAS,TAS | -- |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | NAS,TAS | 19267251 |
GO:0005070 | SH3/SH2 adaptor activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002102 | podosome | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 16441665 |
GO:0005739 | mitochondrion | IEA,IDA | 19767770 |
GO:0005743 | mitochondrial inner membrane | IEA,IDA | 12615910 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Negative regulation of FGFR3 signaling | ||
3 | EPH-Ephrin signaling |
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
.35
|
Cell adhesion Ephrins signaling
.35
.01
|
4 | GAB1 signalosome |
.89
|
|
5 | Development Endothelin-1/EDNRA signaling |
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
Cytoskeleton remodeling FAK signaling
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001545 | primary ovarian follicle growth | IEA | -- |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dasatinib | Approved, Investigational | Pharma | Target, multitarget, Inhibition, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 324 | |
bosutinib | Approved | Pharma | Target, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
Ponatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 57 | |
Citric acid | Approved, Vet_approved | Nutra | Activator, Agonist, Target | 1509 | ||
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
PD 166285 dihydrochloride |
|
212391-63-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
Herbimycin A | Src family kinase inhibitor. Also Hsp90 inhibitor | 70563-58-5 |
MNS | Selective inhibitor of Src and Syk | 1485-00-3 |
PD 166285 dihydrochloride | Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 | 212391-63-4 |
PP 3 | Negative control for PP 2 (Cat. No. 1407) | 5334-30-5 |
Compound | Action | Cas Number |
---|---|---|
1-NM-PP1 | Pp60c-src inhibitor | 221244-14-0 |
Bosutinib (SKI-606) | Potent Abl/Src kinases | 380843-75-4 |
Butein | Protein kinase inhibitor | 487-52-5 |
Damnacanthal | 477-84-9 | |
Dasatinib (BMS-354825) | Src and BCR-Abl inhibitor | 302962-49-8 |
Dasatinib Monohydrate | Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases. | 863127-77-9 |
ER 27319 maleate | 1204480-26-1 | |
Herbimycin A | antibiotic and inhibitor of non-receptor tyrosine kinases | 70563-58-5 |
Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
KB SRC 4 | 1380088-03-8 | |
KX1-004 | Pp60c-src inhibitor | 518058-84-9 |
KX2-391 | Src inhibitor,highly selective | 897016-82-9 |
KX2-391 dihydrochloride | Src kinase inhibitor | 1038395-65-1 |
MLR 1023 | 41964-07-2 | |
MNS | Inhibitor of Src/Syk tyrosine kinases | 1485-00-3 |
NVP-BHG712 | EphB4 inhibitor,potent and selective | 940310-85-0 |
PD173955 | Dual Src/Abl kinase inhibitor, ATP-competitive, | 260415-63-2 |
Ponatinib (AP24534) | pan-BCR-ABL inhibitor,multi-kinase inhibitor | 943319-70-8 |
PP 1 | Src family tyrosine kinase inhibitor | 172889-26-8 |
PP 2 (AG 1879) | Src-family kinases inhibitor | 172889-27-9 |
PP 3 | 5334-30-5 | |
PP121 | Dual inhibitor of tyrosine and phosphoinositide kinases | 1092788-83-4 |
Saracatinib (AZD0530) | Src/Abl inhibitor,potent and selective | 379231-04-6 |
Src I1 | 179248-59-0 | |
SU6656 | Src tyrosine kinases inhibitor | 330161-87-0 |
WH-4-023 | Lck/Src inhibitor,potent and selective | 837422-57-8 |
XL228 | IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor | 898280-07-4 |
ZM 306416 | VEGFR (Flt and KDR) inhibitor | 690206-97-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SRC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SRC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SRC 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SRC 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Src 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Src 30 |
|
||
Chicken (Gallus gallus) |
Aves | SRC 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SRC 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | src 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | src 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8231 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006510 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Src64B 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708134 | Benign: not provided | 37,394,002(+) | C/T | INTRON_VARIANT | |
713171 | Benign: not provided | 37,403,235(+) | G/A | SYNONYMOUS_VARIANT | |
714817 | Benign: not provided | 37,402,446(+) | C/A | SYNONYMOUS_VARIANT | |
714899 | Benign: not provided | 37,393,931(+) | A/G | SYNONYMOUS_VARIANT | |
719597 | Benign: not provided | 37,402,572(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2249n106 | CNV | deletion | 24896259 |
dgv4305n100 | CNV | gain | 25217958 |
dgv4306n100 | CNV | gain | 25217958 |
dgv4307n100 | CNV | gain | 25217958 |
dgv510n27 | CNV | loss | 19166990 |
dgv7565n54 | CNV | loss | 21841781 |
dgv7566n54 | CNV | loss | 21841781 |
esv2722386 | CNV | deletion | 23290073 |
esv2722387 | CNV | deletion | 23290073 |
esv2722388 | CNV | deletion | 23290073 |
nsv1055206 | CNV | loss | 25217958 |
nsv1118914 | CNV | deletion | 24896259 |
nsv1138957 | CNV | deletion | 24896259 |
nsv458967 | CNV | loss | 19166990 |
nsv470551 | CNV | gain | 18288195 |
nsv509767 | CNV | insertion | 20534489 |
nsv516343 | CNV | gain+loss | 19592680 |
nsv523618 | CNV | loss | 19592680 |
nsv523834 | CNV | gain | 19592680 |
nsv524059 | CNV | loss | 19592680 |
nsv528371 | CNV | loss | 19592680 |
nsv585953 | CNV | loss | 21841781 |
nsv585956 | CNV | loss | 21841781 |
nsv833968 | CNV | gain | 17160897 |
nsv954031 | CNV | deletion | 24416366 |
nsv954032 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
thrombocytopenia 6 |
|
|
myelofibrosis |
|
|
osteoporosis |
|
|
thrombocytopenia |
|
|
colorectal cancer |
|