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SRC Gene(Protein Coding)

SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase

GCID:
GC20P037344
GIFtS:
61
Genes Participants
UDN Logo

Aliases for SRC Gene

Aliases for SRC Gene

  • SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase 2 3 5
  • V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Src 3 4
  • EC 2.7.10.2 4 56
  • P60-Src 3 4
  • SRC1 3 4
  • Proto-Oncogene Tyrosine-Protein Kinase Src 3
  • Protooncogene SRC, Rous Sarcoma 3
  • Tyrosine-Protein Kinase SRC-1 3
  • Tyrosine Kinase Pp60c-Src 3
  • Pp60c-Src 4
  • EC 2.7.10 56
  • C-SRC 3
  • THC6 3
  • ASV 3

External Ids for SRC Gene

Previous HGNC Symbols for SRC Gene

  • SRC1

Previous GeneCards Identifiers for SRC Gene

  • GC20P035740
  • GC20P036650
  • GC20P036696
  • GC20P036658
  • GC20P035406
  • GC20P035973
  • GC20P032708

Summaries for SRC Gene

Entrez Gene Summary for SRC Gene

  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRC Gene

SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SRC include Thrombocytopenia 6 and Colorectal Cancer. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is YES1.

UniProtKB/Swiss-Prot for SRC Gene

  • Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at Tyr-1477. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on Tyr-284 and CBL on Tyr-731 (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at Tyr-9, Tyr-373 and Tyr-376 (PubMed:14585963). Phosphorylates BCAR1 at Tyr-128 (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at Tyr-341 activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).

Tocris Summary for SRC Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for SRC Gene

Additional gene information for SRC Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRC Gene

Genomics for SRC Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SRC Gene

Promoters and enhancers for SRC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20I037343 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 574.8 +2.3 2330 7.8 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF143 SRC GC20M037240 MANBAL MROH8 TTI1 DSN1 CTNNBL1 SAMHD1 LOC105372606 RPL7AP14
GH20I037378 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 576.9 +36.3 36272 5.5 HDGF SMAD1 FOXA2 MLX ARID4B SIN3A POLR2B ZNF766 FOS MXD4 SRC MANBAL SAMHD1 CTNNBL1 GC20M037240 RPL7AP14
GH20I037342 Enhancer 1 Ensembl ENCODE dbSUPER 550.8 -1.8 -1784 0.2 GATAD2A CTCF SAP130 ZNF189 ZFP64 ARID4B ZNF644 RAD21 ZNF148 ZKSCAN8 LOC105372606 SRC MANBAL GC20M037240 GC20M037319
GH20I037335 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.7 -8.0 -7958 2.7 HDGF FOXA2 SMAD1 MLX ARID4B DMAP1 IRF4 ZNF48 SLC30A9 TCF12 MANBAL SRC GHRH SAMHD1 CTNNBL1 LOC105372606 GC20M037240 GC20M037319
GH20I037293 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.1 -48.5 -48491 5.6 PKNOX1 KLF17 BATF ZEB1 ZNF366 FOS IKZF2 RUNX3 SP3 USF2 MANBAL SRC SAMHD1 CTNNBL1 PIR39095 GC20M037240
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRC gene promoter:

Genomic Locations for SRC Gene

Genomic Locations for SRC Gene
chr20:37,344,685-37,406,050
(GRCh38/hg38)
Size:
61,366 bases
Orientation:
Plus strand
chr20:35,973,088-36,034,453
(GRCh37/hg19)

Genomic View for SRC Gene

Genes around SRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SRC Gene

Proteins for SRC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12931-SRC_HUMAN
    Recommended name:
    Proto-oncogene tyrosine-protein kinase Src
    Protein Accession:
    P12931
    Secondary Accessions:
    • E1P5V4
    • Q76P87
    • Q86VB9
    • Q9H5A8

    Protein attributes for SRC Gene

    Size:
    536 amino acids
    Molecular mass:
    59835 Da
    Quaternary structure:
    • Interacts with DDEF1/ASAP1; via the SH3 domain (By similarity). Interacts with CCPG1 (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts with ERBB2, STAT1 and PNN (By similarity). Interacts with DDR1, DDR2 and DAB2 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2 (PubMed:12415108, PubMed:15851033, PubMed:16479011, PubMed:17202804). Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin (PubMed:11152665). Interacts with RALGPS1; via the SH3 domain (PubMed:10747847). Interacts with CAV2 (tyrosine phosphorylated form) (PubMed:12091389, PubMed:15504032). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus (By similarity). Interacts with ARRB1 and ARRB2 (PubMed:10753943, PubMed:9924018). Interacts with SRCIN1 (PubMed:17525734). Interacts with NDFIP2 and more weakly with NDFIP1 (PubMed:20534535). Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1 and ESR1 (dimethylated on arginine) (PubMed:18657504, PubMed:21411625). Interacts with FASLG (PubMed:19807924). Interacts (via SH2 domain) with the Tyr-402 phosphorylated form of PTK2B/PYK2 (PubMed:14585963). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated) (By similarity). Interacts with PDGFRA (tyrosine phosphorylated) (By similarity). Interacts with CSF1R (By similarity). Interacts (via SH2 and SH3 domain) with TNK2 (PubMed:21309750). Interacts (via protein kinase domain) with the tyrosine phosphorylated form of RUNX3 (via runt domain) (PubMed:20100835). Interacts with TRAF3 (via RING-type zinc finger domain) (PubMed:19419966). Interacts with DDX58, MAVS and TBK1 (PubMed:19419966). Interacts (via SH2 domain) with RACK1; the interaction is enhanced by tyrosine phosphorylation of RACK1 and inhibits SRC activity (PubMed:9584165, PubMed:11279199). Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:12925710). Interacts with FCAMR (PubMed:8759729). Interacts (via SH2 domain) with the Tyr-9 phosphorylated form of PDPK1 (PubMed:18024423). Interacts with AMOTL2; this interaction regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites (PubMed:17293535). Interacts with TRAP1 (PubMed:23564345). Interacts with CBLC; the interaction is enhanced when SRC is phosphorylated at Tyr-419 (PubMed:14661060, PubMed:22888118). Interacts with ARHGEF5 (By similarity). Interacts (via cytoplasmic domain) with CEACAM1 (via SH2 domain); this interaction is regulated by trans-homophilic cell adhesion (PubMed:7478590). Interacts with MPP2 (PubMed:19665017). Interacts with PRR7 (PubMed:21460222). Interacts (via kinase domain and to a lesser extent the SH2 domain) directly with PDLIM4; this interaction results in PTPN13-mediated dephosphorylation of this protein leading to its inactivation (PubMed:19307596).
    • (Microbial infection) Interacts with HEV ORF3 protein; via the SH3 domain.

    Three dimensional structures from OCA and Proteopedia for SRC Gene

    Alternative splice isoforms for SRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRC Gene

Protein Expression for SRC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for SRC Gene

P12931:
  • KTLKPGTM
  • FVALYDYE
  • KWTAPEA
  • KHYKIRKLD
  • FLEDYFT
  • DMAAQIA
  • SQRRRSLEP
  • EPKLFGGFN
  • IKSDVWSFGILL
  • GKITRRE
  • RGYRMPCP
  • AQIASGMAYV
  • FTIKSDVWSFG
  • VSEEPIYIV
  • HEKLVQLY
  • PIYIVTE
  • GTWNGTT
  • DSIQAEEWY
  • QEAQVMKK
  • VKHYKIR
  • GYIPSNYVA
  • ADFGLARLIED
  • KGSLLDFLK
  • HRDLRAANILV
  • SDTVTSPQRAG
  • DLSFKKG
  • ENPRGTFLVR
  • KSDVWSFG
  • LPQLVDM
  • KFPIKWTAPE
  • PEAFLQEAQ
  • RESETTKGA
  • SLQQLVAYYSKHADGLCHRL
  • KLVQLYAVV
  • DAWEIPR
  • SGGFYITSRTQF
  • FGEVWMGTWN
  • KGRVPYPGM
  • GTMSPEAFL
  • PEERPTFE
  • EPQYQPG

Post-translational modifications for SRC Gene

  • Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity.
  • Myristoylated at Gly-2, and this is essential for targeting to membranes.
  • S-nitrosylation is important for activation of its kinase activity.
  • Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-419 and may lead to lysosomal degradation.

Other Protein References for SRC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SRC (Src)

Domains & Families for SRC Gene

Gene Families for SRC Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SRC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12931

UniProtKB/Swiss-Prot:

SRC_HUMAN :
  • The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with SRC: view

Function for SRC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SRC Gene

GENATLAS Biochemistry:
avian sarcoma (Schmidt-Ruppin A-2) viral (v-src) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation by CSK at Tyr-530 inhibits kinase activity. Inhibitory phosphorylation at Tyr-530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide inhibitors like CIYKYYF act as inhibitors. Phosphorylation at Tyr-419 increases kinase activity.
UniProtKB/Swiss-Prot Function:
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at Tyr-1477. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on Tyr-284 and CBL on Tyr-731 (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at Tyr-9, Tyr-373 and Tyr-376 (PubMed:14585963). Phosphorylates BCAR1 at Tyr-128 (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at Tyr-341 activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).

Enzyme Numbers (IUBMB) for SRC Gene

Phenotypes From GWAS Catalog for SRC Gene

Gene Ontology (GO) - Molecular Function for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS --
GO:0004713 protein tyrosine kinase activity IMP,TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 19267251
GO:0005070 SH3/SH2 adaptor activity TAS 9020193
GO:0005080 protein kinase C binding IEA --
genes like me logo Genes that share ontologies with SRC: view
genes like me logo Genes that share phenotypes with SRC: view

Human Phenotype Ontology for SRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SRC Gene

MGI Knock Outs for SRC:
  • Src tm1Sor
  • Src tm2a(EUCOMM)Wtsi

Animal Model Products

Clone Products

  • Addgene plasmids for SRC

No data available for Transcription Factor Targets and HOMER Transcription for SRC Gene

Localization for SRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRC Gene

Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269 PubMed:19307596, ECO:0000269 PubMed:7525268}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRC gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
lysosome 5
endosome 5
cytoskeleton 4
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 16441665
GO:0005739 mitochondrion IEA,IDA 19767770
genes like me logo Genes that share ontologies with SRC: view

Pathways & Interactions for SRC Gene

SuperPathways for SRC Gene

PathCards logo More details on SuperPathways for SRC
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Negative regulation of FGFR3 signaling
Signaling by FGFR3
.84
Signaling by FGFR4
.84
Negative regulation of FGFR3 signaling
.82
Negative regulation of FGFR4 signaling
.82
Negative regulation of FGFR1 signaling
.81
Negative regulation of FGFR2 signaling
.81
Signaling by FGFR1
.70
Spry regulation of FGF signaling
.01
3 EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
.51
EPH-Ephrin signaling
.51
EPHB-mediated forward signaling
.44
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
.35
Cell adhesion Ephrins signaling
.35
EPHB forward signaling
.30
Ephrin signaling
.01
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
5 Development Endothelin-1/EDNRA signaling
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
Cytoskeleton remodeling FAK signaling
.41
GnRH signaling pathway
.38
Inflammatory mediator regulation of TRP channels
.38
genes like me logo Genes that share pathways with SRC: view

Pathways by source for SRC Gene

1 GeneTex pathway for SRC Gene
2 Cell Signaling Technology pathways for SRC Gene
1 PharmGKB pathway for SRC Gene
1 Tocris pathway for SRC Gene

SIGNOR curated interactions for SRC Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001545 primary ovarian follicle growth IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with SRC: view

Drugs & Compounds for SRC Gene

Products:

  1. Drug

(166) Drugs for SRC Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target, multitarget, Inhibition, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 295
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
ponatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 36
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243
Nintedanib Approved Pharma Target, inhibitor VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors 126

(54) Additional Compounds for SRC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(4) Tocris Compounds for SRC Gene

Compound Action Cas Number
Herbimycin A Src family kinase inhibitor. Also Hsp90 inhibitor 70563-58-5
MNS Selective inhibitor of Src and Syk 1485-00-3
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 212391-63-4
PP 3 Negative control for PP 2 (Cat. No. 1407) 5334-30-5

(35) ApexBio Compounds for SRC Gene

Compound Action Cas Number
1-NM-PP1 Pp60c-src inhibitor 221244-14-0
Bosutinib (SKI-606) Potent Abl/Src kinases 380843-75-4
Butein Protein kinase inhibitor 487-52-5
Damnacanthal 477-84-9
Dasatinib (BMS-354825) Src and BCR-Abl inhibitor 302962-49-8
Dasatinib hydrochloride Multi-BCR/Abl and Src kinase inhibitor, oral active 854001-07-3
Dasatinib Monohydrate Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases. 863127-77-9
ER 27319 maleate 1204480-26-1
Herbimycin A antibiotic and inhibitor of non-receptor tyrosine kinases 70563-58-5
Kaempferol Apoptosis inducer;antioxidant;flavonoid 520-18-3
KB SRC 4 1380088-03-8
KX1-004 Pp60c-src inhibitor 518058-84-9
KX2-391 Src inhibitor,highly selective 897016-82-9
KX2-391 dihydrochloride Src kinase inhibitor 1038395-65-1
Lck inhibitor 2 Tyrosine kinases inhibitor 944795-06-6
MLR 1023 41964-07-2
MNS Inhibitor of Src/Syk tyrosine kinases 1485-00-3
N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide 190078-50-3
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu 159439-02-8
NVP-BHG712 EphB4 inhibitor,potent and selective 940310-85-0
PD173955 Dual Src/Abl kinase inhibitor, ATP-competitive, 260415-63-2
Ponatinib (AP24534) pan-BCR-ABL inhibitor,multi-kinase inhibitor 943319-70-8
PP 1 Src family tyrosine kinase inhibitor 172889-26-8
PP 2 (AG 1879) Src-family kinases inhibitor 172889-27-9
PP 3 5334-30-5
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
pp60 c-src (521-533) (phosphorylated) 149299-77-4
Saracatinib (AZD0530) Src/Abl inhibitor,potent and selective 379231-04-6
Src I1 179248-59-0
SU6656 Src tyrosine kinases inhibitor 330161-87-0
TG 100572 867334-05-2
TG 100572 Hydrochloride 867331-64-4
WH-4-023 Lck/Src inhibitor,potent and selective 837422-57-8
XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor 898280-07-4
ZM 306416 VEGFR (Flt and KDR) inhibitor 690206-97-4
genes like me logo Genes that share compounds with SRC: view

Drug Products

Transcripts for SRC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SRC Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRC Gene

V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian):
Representative Sequences:

Clone Products

  • Addgene plasmids for SRC

Alternative Splicing Database (ASD) splice patterns (SP) for SRC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for SRC Gene

GeneLoc Exon Structure for
SRC
ECgene alternative splicing isoforms for
SRC

Expression for SRC Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRC Gene

mRNA expression in normal human tissues for SRC Gene
mRNA expression by BioGPS for SRC GenemRNA expression by GTEx for SRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRC Gene

This gene is overexpressed in Platelet (23.2), Peripheral blood mononuclear cells (14.3), and Testis (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRC Gene



Protein tissue co-expression partners for SRC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRC Gene:

SRC

SOURCE GeneReport for Unigene cluster for SRC Gene:

Hs.195659

mRNA Expression by UniProt/SwissProt for SRC Gene:

P12931-SRC_HUMAN
Tissue specificity: Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.

Evidence on tissue expression from TISSUES for SRC Gene

  • Blood(4.7)
  • Lung(4.6)
  • Liver(4.5)
  • Skin(4.5)
  • Kidney(3.2)
  • Nervous system(3.1)
  • Heart(3)
  • Intestine(2.9)
  • Muscle(2.8)
  • Stomach(2.8)
  • Adrenal gland(2.7)
  • Bone marrow(2.6)
  • Spleen(2.6)
  • Bone(2.4)
  • Pancreas(2.4)
  • Eye(2.3)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with SRC: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRC Gene

Orthologs for SRC Gene

This gene was present in the common ancestor of animals.

Orthologs for SRC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SRC 33 34
  • 99.69 (n)
cow
(Bos Taurus)
 Mammalia SRC 33 34
  • 92.79 (n)
dog
(Canis familiaris)
 Mammalia SRC 33 34
  • 92.41 (n)
oppossum
(Monodelphis domestica)
 Mammalia SRC 34
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Src 33 16 34
  • 90.09 (n)
rat
(Rattus norvegicus)
 Mammalia Src 33
  • 89.91 (n)
chicken
(Gallus gallus)
 Aves SRC 33 34
  • 85.8 (n)
lizard
(Anolis carolinensis)
 Reptilia SRC 34
  • 93 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia src 33
  • 76.63 (n)
zebrafish
(Danio rerio)
 Actinopterygii src 33 34
  • 76.06 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8231 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006510 33
  • 59.32 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Src64B 33
  • 57.91 (n)
Species where no ortholog for SRC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRC Gene

ENSEMBL:
Gene Tree for SRC (if available)
TreeFam:
Gene Tree for SRC (if available)

Paralogs for SRC Gene

Paralogs for SRC Gene

(112) SIMAP similar genes for SRC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SRC: view

Variants for SRC Gene

Sequence variations from dbSNP and Humsavar for SRC Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs121913314 pathogenic, likely-pathogenic, Colon cancer, advanced, Neoplasm 37,403,359(+) C/T coding_sequence_variant, stop_gained
rs367543243 uncertain-significance, not-provided, not provided 37,402,518(+) C/G/T coding_sequence_variant, missense_variant, synonymous_variant
rs879255268 pathogenic, Thrombocytopenia 6, Thrombocytopenia 6 (THC6) [MIM:616937] 37,403,347(+) G/A coding_sequence_variant, missense_variant
rs367543237 not-provided, not provided 37,384,165(+) C/T coding_sequence_variant, synonymous_variant
rs367543238 not-provided, not provided 37,384,214(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SRC Gene

Variant ID Type Subtype PubMed ID
nsv954032 CNV deletion 24416366
nsv954031 CNV deletion 24416366
nsv833968 CNV gain 17160897
nsv585956 CNV loss 21841781
nsv585953 CNV loss 21841781
nsv528371 CNV loss 19592680
nsv524059 CNV loss 19592680
nsv523834 CNV gain 19592680
nsv523618 CNV loss 19592680
nsv516343 CNV gain+loss 19592680
nsv509767 CNV insertion 20534489
nsv470551 CNV gain 18288195
nsv458967 CNV loss 19166990
nsv1138957 CNV deletion 24896259
nsv1118914 CNV deletion 24896259
nsv1055206 CNV loss 25217958
esv2722388 CNV deletion 23290073
esv2722387 CNV deletion 23290073
esv2722386 CNV deletion 23290073
dgv7566n54 CNV loss 21841781
dgv7565n54 CNV loss 21841781
dgv510n27 CNV loss 19166990
dgv4307n100 CNV gain 25217958
dgv4306n100 CNV gain 25217958
dgv4305n100 CNV gain 25217958
dgv2249n106 CNV deletion 24896259

Variation tolerance for SRC Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRC Gene

Human Gene Mutation Database (HGMD)
SRC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRC Gene

Disorders for SRC Gene

MalaCards: The human disease database

(34) MalaCards diseases for SRC Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenia 6
  • thc6
colorectal cancer
  • crc
sarcoma
  • connective and soft tissue neoplasm
cherubism
  • crbm
mucinous stomach adenocarcinoma
  • mucinous adenocarcinoma of the stomach
- elite association - COSMIC cancer census association via MalaCards
Search SRC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SRC_HUMAN
  • Note=SRC kinase activity has been shown to be increased in several tumor tissues and tumor cell lines such as colon carcinoma cells. {ECO:0000269 PubMed:2498394, ECO:0000269 PubMed:3093483}.
  • Thrombocytopenia 6 (THC6) [MIM:616937]: A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC6 is an autosomal dominant form. Affected individuals may also have bone abnormalities and an increased risk for myelofibrosis. {ECO:0000269 PubMed:26936507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SRC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SRC: view

No data available for Genatlas for SRC Gene

Publications for SRC Gene

  1. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PMID: 20100835) Goh YM … Bae SC (The Journal of biological chemistry 2010) 3 4 22 58
  2. Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. (PMID: 19307596) Zhang Y … Wu C (The Journal of cell biology 2009) 3 4 22 58
  3. The PDZ protein MPP2 interacts with c-Src in epithelial cells. (PMID: 19665017) Baumgartner M … Moelling K (Experimental cell research 2009) 3 4 22 58
  4. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PMID: 16186108) Yang K … Yang BS (The Journal of biological chemistry 2005) 3 4 22 58
  5. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PMID: 12925710) Vindis C … Huynh-Do U (The Journal of cell biology 2003) 3 4 22 58

Products for SRC Gene