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Aliases for SRARP Gene

Aliases for SRARP Gene

  • Steroid Receptor Associated And Regulated Protein 2 3 5
  • ER-Related Factor 2 3 4
  • Steroid Receptor-Associated And Regulated Protein 3 4
  • Steroid Receptor-Regulated Protein 3 4
  • C1orf64 3 4
  • ERRF 3 4
  • Chromosome 1 Open Reading Frame 64 2
  • Uncharacterized Protein C1orf64 3
  • SSPR 4

External Ids for SRARP Gene

Previous HGNC Symbols for SRARP Gene

  • C1orf64

Summaries for SRARP Gene

GeneCards Summary for SRARP Gene

SRARP (Steroid Receptor Associated And Regulated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRARP Gene

  • May regulate the transcriptional function of androgen and estrogen receptors.

Additional gene information for SRARP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRARP Gene

Genomics for SRARP Gene

GeneHancer (GH) Regulatory Elements for SRARP Gene

Promoters and enhancers for SRARP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J016004 Promoter/Enhancer 1.4 EPDnew Ensembl 600.7 -0.1 -112 0.2 SP1 ELF3 MNT POLR2A RERE ZNF24 TFE3 PPARG SP5 ZNF644 SRARP PIR42965
GH01J015974 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.6 -28.6 -28588 2.7 SP1 ZFX SIX5 ZNF148 NKRF ZNF121 CEBPG GTF2F1 AHR ZNF24 TBC1D3P6 ZBTB17 HSPB7 CROCCP3 LINC01772 CROCC SRARP ENSG00000234607
GH01J015947 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -53.1 -53057 7.3 SP1 CC2D1A ZKSCAN8 CBFA2T2 ZNF148 MLLT1 ZNF121 CEBPG GTF2F1 ZNF687 SPEN ENSG00000237938 HSPB7 CLCNKA RPL22P3 PLEKHM2 ZBTB17 ENSG00000233078 ENSG00000178715 CROCC
GH01J015829 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.3 -170.3 -170335 9 SP1 ZFX ELF3 ZKSCAN8 ZNF148 NKRF POLR2A MLLT1 ZNF121 CEBPG SPEN ENSG00000237938 ZBTB17 CROCC CLCNKA ENSG00000179743 HSPB7 ENSG00000178715 RPL22P3 EFHD2
GH01J015777 Enhancer 1.1 ENCODE dbSUPER 12.1 -224.4 -224351 4.7 ELF3 ZNF121 CEBPG RERE BACH1 MAFK TFE3 SP1 HNF1A PPARG FBLIM1 ENSG00000237938 SLC25A34 SRARP ARHGEF19 CLCNKB CASP9 RPL12P14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRARP on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRARP Gene

Genomic Locations for SRARP Gene
chr1:16,004,236-16,008,807
(GRCh38/hg38)
Size:
4,572 bases
Orientation:
Plus strand
chr1:16,330,731-16,335,302
(GRCh37/hg19)
Size:
4,572 bases
Orientation:
Plus strand

Genomic View for SRARP Gene

Genes around SRARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRARP Gene

Proteins for SRARP Gene

  • Protein details for SRARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEQ6-SRARP_HUMAN
    Recommended name:
    Steroid receptor-associated and regulated protein
    Protein Accession:
    Q8NEQ6
    Secondary Accessions:
    • B3KXI9

    Protein attributes for SRARP Gene

    Size:
    169 amino acids
    Molecular mass:
    17657 Da
    Quaternary structure:
    • Interacts with 14-3-3 proteins (PubMed:28915724).

neXtProt entry for SRARP Gene

Post-translational modifications for SRARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRARP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRARP Gene

Domains & Families for SRARP Gene

Gene Families for SRARP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRARP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRARP: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SRARP Gene

Function for SRARP Gene

Molecular function for SRARP Gene

UniProtKB/Swiss-Prot Function:
May regulate the transcriptional function of androgen and estrogen receptors.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast cancers (PubMed:22341523).

Phenotypes From GWAS Catalog for SRARP Gene

Gene Ontology (GO) - Molecular Function for SRARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030331 estrogen receptor binding IPI 27125460
genes like me logo Genes that share ontologies with SRARP: view
genes like me logo Genes that share phenotypes with SRARP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRARP

Clone Products

  • Applied Biological Materials (abm): Clones for SRARP - Now 50% OFF >
  • * SRARP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SRARP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRARP Gene

Localization for SRARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRARP gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22341523
GO:0005737 cytoplasm IDA 22341523
genes like me logo Genes that share ontologies with SRARP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SRARP Gene

Pathways & Interactions for SRARP Gene

PathCards logo

SuperPathways for SRARP Gene

No Data Available

Interacting Proteins for SRARP Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332162%0d9606.ENSP00000419412%0d9606.ENSP00000378830%0d
Selected Interacting proteins: ENSP00000332162 Q8NEQ6-SRARP_HUMAN for SRARP Gene via STRING IID

Gene Ontology (GO) - Biological Process for SRARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IMP 27125460
genes like me logo Genes that share ontologies with SRARP: view

No data available for Pathways by source and SIGNOR curated interactions for SRARP Gene

Drugs & Compounds for SRARP Gene

No Compound Related Data Available

Transcripts for SRARP Gene

mRNA/cDNA for SRARP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRARP

Clone Products

  • Applied Biological Materials (abm): Clones for SRARP - Now 50% OFF >
  • * SRARP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SRARP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SRARP Gene

No ASD Table

Relevant External Links for SRARP Gene

GeneLoc Exon Structure for
SRARP
ECgene alternative splicing isoforms for
SRARP

Expression for SRARP Gene

NURSA nuclear receptor signaling pathways regulating expression of SRARP Gene:

SRARP

mRNA Expression by UniProt/SwissProt for SRARP Gene:

Q8NEQ6-SRARP_HUMAN
Tissue specificity: Expressed in breast tumors with a higher expression level in estrogen receptor-positive cancers (PubMed:22341523, PubMed:28915724).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRARP Gene

Orthologs for SRARP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SRARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf64 35
  • 99 (a)
OneToOne
C1H1orf64 34
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia C2H1orf64 35 34
  • 71.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf64 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm694 35 34
  • 64.4 (n)
OneToOne
Srarp 17
rat
(Rattus norvegicus)
Mammalia RGD1566083 34
  • 64.36 (n)
Species where no ortholog for SRARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRARP Gene

ENSEMBL:
Gene Tree for SRARP (if available)
TreeFam:
Gene Tree for SRARP (if available)

Paralogs for SRARP Gene

No data available for Paralogs for SRARP Gene

Variants for SRARP Gene

Sequence variations from dbSNP and Humsavar for SRARP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035491 A breast cancer sample p.Gly52Trp
VAR_035492 A breast cancer sample p.Gly100Trp
rs1000173300 -- 16,005,062(+) G/T intron_variant
rs1000775103 -- 16,004,049(+) G/A upstream_transcript_variant
rs1001083012 -- 16,003,790(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SRARP Gene

Variant ID Type Subtype PubMed ID
nsv508936 CNV insertion 20534489
nsv517651 CNV gain+loss 19592680
nsv520148 CNV loss 19592680
nsv524045 CNV loss 19592680
nsv545627 CNV loss 21841781
nsv833758 CNV gain+loss 17160897
nsv997887 CNV gain 25217958

Variation tolerance for SRARP Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRARP Gene

Disorders for SRARP Gene

Additional Disease Information for SRARP

No disorders were found for SRARP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRARP Gene

Publications for SRARP Gene

  1. C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer. (PMID: 28915724) Naderi A (Oncotarget 2017) 2 3 4 58
  2. ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells. (PMID: 27125460) Luo A … Zhang X (Biochemical and biophysical research communications 2016) 2 3 4 58
  3. SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies. (PMID: 29577611) Naderi A (Molecular oncology 2018) 2 3 58
  4. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. (PMID: 22341523) Su D … Dong JT (The American journal of pathology 2012) 3 4 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for SRARP Gene

Sources for SRARP Gene

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