Aliases for SRA1 Gene
External Ids for SRA1 Gene
Previous GeneCards Identifiers for SRA1 Gene
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
GeneCards Summary for SRA1 Gene
SRA1 (Steroid Receptor RNA Activator 1) is a Protein Coding gene. Diseases associated with SRA1 include Laryngeal Squamous Cell Carcinoma and Dilated Cardiomyopathy. Among its related pathways are GPCR Pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot Summary for SRA1 Gene
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.