Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR ac... See more...

Aliases for SRA1 Gene

Aliases for SRA1 Gene

  • Steroid Receptor RNA Activator 1 2 3 4 5
  • Steroid Receptor RNA Activator Protein 3 4
  • SRAP 3 4
  • Steroid Receptor RNA Activator 1 (Complexes With NCOA1) 3
  • Steriod Receptor RNA Activator 1 2
  • Steroid Receptor Coactivator 3
  • STRAA1 3
  • Pp7684 3
  • SRA 3

External Ids for SRA1 Gene

Previous GeneCards Identifiers for SRA1 Gene

  • GC05M139746
  • GC05M140512
  • GC05M139912
  • GC05M139958
  • GC05M139909
  • GC05M139911
  • GC05M135074

Summaries for SRA1 Gene

Entrez Gene Summary for SRA1 Gene

  • Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRA1 Gene

SRA1 (Steroid Receptor RNA Activator 1) is a Protein Coding gene. Diseases associated with SRA1 include Laryngeal Squamous Cell Carcinoma and Dilated Cardiomyopathy. Among its related pathways are GPCR Pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot Summary for SRA1 Gene

  • Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Gene Wiki entry for SRA1 Gene

Additional gene information for SRA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRA1 Gene

Genomics for SRA1 Gene

GeneHancer (GH) Regulatory Elements for SRA1 Gene

Promoters and enhancers for SRA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRA1

Top Transcription factor binding sites by QIAGEN in the SRA1 gene promoter:
  • CREB
  • deltaCREB
  • NRSF form 1
  • p53
  • TBP
  • TFIID

Genomic Locations for SRA1 Gene

Genomic Locations for SRA1 Gene
chr5:140,537,340-140,558,252
(GRCh38/hg38)
Size:
20,913 bases
Orientation:
Minus strand
chr5:139,916,925-139,937,895
(GRCh37/hg19)
Size:
20,971 bases
Orientation:
Minus strand

Genomic View for SRA1 Gene

Genes around SRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRA1 Gene

Proteins for SRA1 Gene

  • Protein details for SRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD15-SRA1_HUMAN
    Recommended name:
    Steroid receptor RNA activator 1
    Protein Accession:
    Q9HD15
    Secondary Accessions:
    • Q6NVU9
    • Q8IXM1
    • Q9HD13
    • Q9HD14

    Protein attributes for SRA1 Gene

    Size:
    236 amino acids
    Molecular mass:
    25673 Da
    Quaternary structure:
    • SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.
    Miscellaneous:
    • Appears to be the first example of a new class of functional RNAs also able to encode a protein.
    SequenceCaution:
    • Sequence=AAH40043.2; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRA1 Gene

neXtProt entry for SRA1 Gene

Post-translational modifications for SRA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRA1 Gene

Domains & Families for SRA1 Gene

Gene Families for SRA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRA1 Gene

Suggested Antigen Peptide Sequences for SRA1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ30398 fis, clone BRACE2008402, highly similar to Steroid receptor RNA activator 1 (B3KNT3_HUMAN)
  • Steroid receptor RNA activator protein (SRA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HD15

UniProtKB/Swiss-Prot:

SRA1_HUMAN :
  • Belongs to the SRA1 family.
Family:
  • Belongs to the SRA1 family.
genes like me logo Genes that share domains with SRA1: view

Function for SRA1 Gene

Molecular function for SRA1 Gene

UniProtKB/Swiss-Prot Function:
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Phenotypes From GWAS Catalog for SRA1 Gene

Gene Ontology (GO) - Molecular Function for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002153 NOT steroid receptor RNA activator RNA binding IDA 24486609
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity IDA 10199399
GO:0005515 protein binding IPI 20398657
GO:0030374 nuclear receptor transcription coactivator activity IBA 21873635
genes like me logo Genes that share ontologies with SRA1: view
genes like me logo Genes that share phenotypes with SRA1: view

Human Phenotype Ontology for SRA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SRA1 Gene

MGI Knock Outs for SRA1:
  • Sra1 Sra1<tm1b(EUCOMM)Hmgu>
  • Sra1 Sra1<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for SRA1 Gene

miRTarBase miRNAs that target SRA1

Clone Products

  • Addgene plasmids for SRA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SRA1 Gene

Localization for SRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRA1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
cytoskeleton 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 12565891
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA,IDA 24486609
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SRA1: view

Pathways & Interactions for SRA1 Gene

PathCards logo

SuperPathways for SRA1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.55
genes like me logo Genes that share pathways with SRA1: view

Pathways by source for SRA1 Gene

1 Qiagen pathway for SRA1 Gene
  • Estrogen Pathway

Gene Ontology (GO) - Biological Process for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 NOT regulation of transcription by RNA polymerase II IMP,IEA 24486609
GO:0006915 apoptotic process IEA --
GO:0008283 cell proliferation IDA 14517287
GO:0030154 cell differentiation IDA 14517287
GO:0042981 regulation of apoptotic process IDA 14517287
genes like me logo Genes that share ontologies with SRA1: view

No data available for SIGNOR curated interactions for SRA1 Gene

Drugs & Compounds for SRA1 Gene

(2) Drugs for SRA1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SRA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRA1: view

Transcripts for SRA1 Gene

mRNA/cDNA for SRA1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for SRA1

Alternative Splicing Database (ASD) splice patterns (SP) for SRA1 Gene

No ASD Table

Relevant External Links for SRA1 Gene

GeneLoc Exon Structure for
SRA1

Expression for SRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRA1 Gene

mRNA differential expression in normal tissues according to GTEx for SRA1 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SRA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.2) and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRA1 Gene



Protein tissue co-expression partners for SRA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRA1

SOURCE GeneReport for Unigene cluster for SRA1 Gene:

Hs.653135

mRNA Expression by UniProt/SwissProt for SRA1 Gene:

Q9HD15-SRA1_HUMAN
Tissue specificity: Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.

Evidence on tissue expression from TISSUES for SRA1 Gene

  • Liver(4.4)
  • Lung(3)
  • Heart(2.6)
  • Nervous system(2.6)
  • Muscle(2.5)
  • Blood(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with SRA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRA1 Gene

Orthologs for SRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRA1 31 30
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SRA1 31 30
  • 89.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SRA1 31 30
  • 85.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sra1 17 31 30
  • 85.28 (n)
rat
(Rattus norvegicus)
Mammalia Sra1 30
  • 83.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRA1 31
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRA1 31
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sra1 30
  • 57.48 (n)
zebrafish
(Danio rerio)
Actinopterygii sra1 31 30
  • 56.45 (n)
OneToOne
Species where no ortholog for SRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRA1 Gene

ENSEMBL:
Gene Tree for SRA1 (if available)
TreeFam:
Gene Tree for SRA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRA1: view image

Paralogs for SRA1 Gene

No data available for Paralogs for SRA1 Gene

Variants for SRA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRA1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
768033 Benign: not provided 140,552,044(-) C/CG FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
785142 Benign: not provided 140,550,722(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
785143 Benign: not provided 140,557,250(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1306465994 Uncertain Significance: Hypogonadism with anosmia 140,551,995(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs35610885 - p.Gln32Glu

Additional dbSNP identifiers (rs#s) for SRA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRA1 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV loss 19166990
nsv599825 CNV loss 21841781

Variation tolerance for SRA1 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.68; 98.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRA1 Gene

Human Gene Mutation Database (HGMD)
SRA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRA1 Gene

Disorders for SRA1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SRA1 Gene - From: LncRNADisease, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
laryngeal squamous cell carcinoma
  • epidermoid carcinoma of the larynx
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
atrial standstill 1
  • atrst1
hypogonadotropic hypogonadism 7 with or without anosmia
  • hh7
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search SRA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SRA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRA1 Gene

Publications for SRA1 Gene

  1. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. (PMID: 10199399) Lanz RB … O'Malley BW (Cell 1999) 2 3 4 23 54
  2. SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. (PMID: 15351741) Coleman KM … Smith CL (Biochemical and biophysical research communications 2004) 3 4 23 54
  3. The steroid receptor RNA activator is the first functional RNA encoding a protein. (PMID: 15147866) Chooniedass-Kothari S … Leygue E (FEBS letters 2004) 3 4 23 54
  4. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. (PMID: 12943696) Deblois G … Giguère V (The Journal of steroid biochemistry and molecular biology 2003) 3 4 23 54
  5. Identification of new human coding steroid receptor RNA activator isoforms. (PMID: 12565891) Emberley E … Leygue E (Biochemical and biophysical research communications 2003) 3 4 23 54

Products for SRA1 Gene

Sources for SRA1 Gene