Aliases for SQLE Gene
External Ids for SQLE Gene
Previous GeneCards Identifiers for SQLE Gene
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for SQLE Gene
SQLE (Squalene Epoxidase) is a Protein Coding gene. Diseases associated with SQLE include Tinea Corporis and Tinea Cruris. Among its related pathways are cholesterol biosynthesis III (via desmosterol) and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and squalene monooxygenase activity.
UniProtKB/Swiss-Prot Summary for SQLE Gene
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.