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The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
SPX (Spexin Hormone) is a Protein Coding gene. Diseases associated with SPX include Hyperoxaluria, Primary, Type Iii and Occupational Dermatitis. Gene Ontology (GO) annotations related to this gene include hormone activity and type 2 galanin receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
GO:0005184 | neuropeptide hormone activity | IEA,IMP | 17284679 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA,IDA | 17284679 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0030133 | transport vesicle | IEA | -- |
GO:0031045 | dense core granule | IDA | 17284679 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003084 | positive regulation of systemic arterial blood pressure | ISS | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0010459 | negative regulation of heart rate | ISS | -- |
GO:0032099 | negative regulation of appetite | ISS | -- |
GO:0035814 | negative regulation of renal sodium excretion | ISS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | C12H12orf39 30 |
|
||
C12orf39 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | C5H12orf39 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | C27H12orf39 30 |
|
||
C12ORF39 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | LOC691138 30 |
|
||
Mouse (Mus musculus) |
Mammalia | B230216G23Rik 30 31 |
|
OneToOne | |
Spx 17 |
|
||||
Chicken (Gallus gallus) |
Aves | C12orf39 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | C12orf39 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC101882535 30 |
|
||
C4H12orf39 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperoxaluria, primary, type iii |
|
|
occupational dermatitis |
|
|
fiedler's myocarditis |
|
|
frontometaphyseal dysplasia 1 |
|
|
noonan syndrome 9 |
|
|