Aliases for SPTY2D1 Gene
External Ids for SPTY2D1 Gene
Previous GeneCards Identifiers for SPTY2D1 Gene
GeneCards Summary for SPTY2D1 Gene
SPTY2D1 (SPT2 Chromatin Protein Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CCDC61.
UniProtKB/Swiss-Prot Summary for SPTY2D1 Gene
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).