Aliases for SPSB1 Gene
External Ids for SPSB1 Gene
Previous GeneCards Identifiers for SPSB1 Gene
GeneCards Summary for SPSB1 Gene
SPSB1 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 1) is a Protein Coding gene. Diseases associated with SPSB1 include Congenital Muscular Dystrophy-Dystroglycanopathy A7. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB4.
UniProtKB/Swiss-Prot Summary for SPSB1 Gene
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).