Aliases for SPRYD7 Gene

Aliases for SPRYD7 Gene

  • SPRY Domain Containing 7 2 3 5
  • Chronic Lymphocytic Leukemia Deletion Region Gene 6 Protein 3 4
  • CLL Deletion Region Gene 6 Protein 3 4
  • SPRY Domain-Containing Protein 7 3 4
  • C13orf1 3 4
  • CLLD6 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 13 Open Reading Frame 1 2

External Ids for SPRYD7 Gene

Previous HGNC Symbols for SPRYD7 Gene

  • C13orf1

Previous GeneCards Identifiers for SPRYD7 Gene

  • GC13M050487

Summaries for SPRYD7 Gene

GeneCards Summary for SPRYD7 Gene

SPRYD7 (SPRY Domain Containing 7) is a Protein Coding gene. Diseases associated with SPRYD7 include Lymphocytic Leukemia.

Gene Wiki entry for SPRYD7 Gene

Additional gene information for SPRYD7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRYD7 Gene

Genomics for SPRYD7 Gene

GeneHancer (GH) Regulatory Elements for SPRYD7 Gene

Promoters and enhancers for SPRYD7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J049934 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.2 +58.4 58424 6.3 EP300 CTCF SIN3A NRF1 POLR2G SP1 ZFX ZNF639 ZNF10 ZIC2 TRIM13 lnc-TRIM13-7 piR-42799-004 SPRYD7 EBPL DLEU1 CTAGE10P DLEU2
GH13J049995 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.3 -1.8 -1798 4.9 HNRNPK CTCF SIN3A TCF12 POLR2G PHF8 ZFX ZNF639 EP300 ZIC2 TRIM13 SPRYD7 MIR3613 KCNRG SETDB2 DLEU1 EBPL CTAGE10P RNASEH2B DLEU2
GH13J049790 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 +203.6 203635 3.5 HNRNPK ZNF217 SIN3A NRF1 TCF12 POLR2G USF1 SP1 NCOR1 PHF8 KPNA3 ENSG00000276436 EBPL SPRYD7 SETDB2 DLEU1 lnc-EBPL-2
GH13J049856 Enhancer 1.1 Ensembl ENCODE 7.9 +137.3 137327 3.5 EP300 FOXK2 ZNF217 TCF12 NCOR1 JUND FOS KDM6A TCF7 FOXA1 EBPL SPRYD7 DLEU1 CTAGE10P TRIM13 HSALNG0097078 RF00019-030 RNY4P30
GH13J049960 Enhancer 0.2 FANTOM5 11.8 +35.6 35566 0.3 SPRYD7 KCNRG KPNA3 lnc-TRIM13-5 piR-32214-152 DLEU2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRYD7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRYD7

Genomic Locations for SPRYD7 Gene

Genomic Locations for SPRYD7 Gene
83,261 bases
Minus strand
23,785 bases
Minus strand

Genomic View for SPRYD7 Gene

Genes around SPRYD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD7 Gene

Proteins for SPRYD7 Gene

  • Protein details for SPRYD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A8K3G1
    • O60648
    • Q8TBG8
    • Q96T69

    Protein attributes for SPRYD7 Gene

    196 amino acids
    Molecular mass:
    21666 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC09363.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPRYD7 Gene


neXtProt entry for SPRYD7 Gene

Post-translational modifications for SPRYD7 Gene

  • Ubiquitination at Lys85
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD7 Gene

No data available for DME Specific Peptides for SPRYD7 Gene

Domains & Families for SPRYD7 Gene

Gene Families for SPRYD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPRYD7 Gene

Suggested Antigen Peptide Sequences for SPRYD7 Gene

GenScript: Design optimal peptide antigens:
  • Chronic lymphocytic leukemia deletion region gene 6 protein (SPRY7_HUMAN)
genes like me logo Genes that share domains with SPRYD7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPRYD7 Gene

Function for SPRYD7 Gene

Phenotypes From GWAS Catalog for SPRYD7 Gene

Gene Ontology (GO) - Molecular Function for SPRYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPRYD7: view
genes like me logo Genes that share phenotypes with SPRYD7: view

Animal Model Products

CRISPR Products

miRNA for SPRYD7 Gene

miRTarBase miRNAs that target SPRYD7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRYD7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD7 Gene

Localization for SPRYD7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD7 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD7 Gene

Pathways & Interactions for SPRYD7 Gene

PathCards logo

SuperPathways for SPRYD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRYD7 Gene

Drugs & Compounds for SPRYD7 Gene

No Compound Related Data Available

Transcripts for SPRYD7 Gene

mRNA/cDNA for SPRYD7 Gene

14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRYD7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for SPRYD7 Gene

GeneLoc Exon Structure for

Expression for SPRYD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRYD7 Gene

Protein differential expression in normal tissues from HIPED for SPRYD7 Gene

This gene is overexpressed in Placenta (13.2) and Bone (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPRYD7 Gene

Protein tissue co-expression partners for SPRYD7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRYD7

SOURCE GeneReport for Unigene cluster for SPRYD7 Gene:


Evidence on tissue expression from TISSUES for SPRYD7 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with SPRYD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRYD7 Gene

Orthologs for SPRYD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRYD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRYD7 31 30
  • 99.66 (n)
(Monodelphis domestica)
Mammalia SPRYD7 31
  • 96 (a)
(Canis familiaris)
Mammalia SPRYD7 31 30
  • 94.2 (n)
(Bos Taurus)
Mammalia SPRYD7 31 30
  • 94.05 (n)
(Ornithorhynchus anatinus)
Mammalia SPRYD7 31
  • 94 (a)
(Mus musculus)
Mammalia Spryd7 17 31 30
  • 90.48 (n)
(Rattus norvegicus)
Mammalia Spryd7 30
  • 90.48 (n)
(Gallus gallus)
Aves SPRYD7 31 30
  • 82.99 (n)
(Anolis carolinensis)
Reptilia SPRYD7 31
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd7 30
  • 80.28 (n)
Str.11085 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24473 30
(Danio rerio)
Actinopterygii spryd7b 31
  • 85 (a)
spryd7a 31 30
  • 74.49 (n)
Dr.13478 30
fruit fly
(Drosophila melanogaster)
Insecta CG7785 31 30
  • 53.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001349 30
  • 51.66 (n)
(Caenorhabditis elegans)
Secernentea F18H3.1 31 30
  • 54.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
Species where no ortholog for SPRYD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPRYD7 Gene

Gene Tree for SPRYD7 (if available)
Gene Tree for SPRYD7 (if available)
Evolutionary constrained regions (ECRs) for SPRYD7: view image

Paralogs for SPRYD7 Gene Pseudogenes for SPRYD7 Gene

genes like me logo Genes that share paralogs with SPRYD7: view

No data available for Paralogs for SPRYD7 Gene

Variants for SPRYD7 Gene

Additional dbSNP identifiers (rs#s) for SPRYD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPRYD7 Gene

Variant ID Type Subtype PubMed ID
esv3632059 CNV loss 21293372
nsv561618 CNV loss 21841781

Variation tolerance for SPRYD7 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRYD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRYD7 Gene

Disorders for SPRYD7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRYD7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphocytic leukemia
  • lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPRYD7

genes like me logo Genes that share disorders with SPRYD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRYD7 Gene

Publications for SPRYD7 Gene

  1. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. (PMID: 11306461) Mabuchi H … Croce CM (Cancer research 2001) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 54
  4. [Transcription map of the 13q14 region, frequently deleted in B-cell chronic lymphocytic leukemia patients]. (PMID: 11771308) Tiazhelova TV … Baranova AV (Genetika 2001) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for SPRYD7 Gene

Sources for SPRYD7 Gene