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Aliases for SPRYD7 Gene

Aliases for SPRYD7 Gene

  • SPRY Domain Containing 7 2 3 5
  • Chronic Lymphocytic Leukemia Deletion Region Gene 6 Protein 3 4
  • CLL Deletion Region Gene 6 Protein 3 4
  • C13orf1 3 4
  • CLLD6 3 4
  • Chromosome 13 Open Reading Frame 1 2
  • SPRY Domain-Containing Protein 7 3

External Ids for SPRYD7 Gene

Previous HGNC Symbols for SPRYD7 Gene

  • C13orf1

Previous GeneCards Identifiers for SPRYD7 Gene

  • GC13M050487

Summaries for SPRYD7 Gene

GeneCards Summary for SPRYD7 Gene

SPRYD7 (SPRY Domain Containing 7) is a Protein Coding gene.

Gene Wiki entry for SPRYD7 Gene

Additional gene information for SPRYD7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD7 Gene

Genomics for SPRYD7 Gene

GeneHancer (GH) Regulatory Elements for SPRYD7 Gene

Promoters and enhancers for SPRYD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I049934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.2 +58.2 58209 5.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SPRYD7 TRIM13 KCNRG SETDB2 EBPL DLEU1 CTAGE10P GC13P049951 RNY4P9 GC13M049909
GH13I049995 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.4 -1.5 -1540 4.4 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ZNF213 ZNF207 TRIM13 SPRYD7 MIR3613 DLEU1 EBPL CTAGE10P RNASEH2B KCNRG DLEU2
GH13I049790 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.7 +203.6 203582 3.3 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KPNA3 ENSG00000276436 EBPL SPRYD7 SETDB2 DLEU1 GC13P049698
GH13I049856 Enhancer 1.1 Ensembl ENCODE 7.9 +137.3 137329 3.5 FOXA2 MLX ARID4B NEUROD1 SIN3A ETS1 YY1 ATF7 FOS RXRA EBPL SPRYD7 DLEU1 CTAGE10P TRIM13 RNY4P30 KPNA3
GH13I049960 Enhancer 0.3 FANTOM5 11.8 +35.6 35566 0.3 SPRYD7 KCNRG KPNA3 GC13P049955 GC13P049980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRYD7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPRYD7 Gene

Genomic Locations for SPRYD7 Gene
chr13:49,912,702-49,995,962
(GRCh38/hg38)
Size:
83,261 bases
Orientation:
Minus strand
chr13:50,486,842-50,510,626
(GRCh37/hg19)

Genomic View for SPRYD7 Gene

Genes around SPRYD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD7 Gene

Proteins for SPRYD7 Gene

  • Protein details for SPRYD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W111-SPRY7_HUMAN
    Recommended name:
    SPRY domain-containing protein 7
    Protein Accession:
    Q5W111
    Secondary Accessions:
    • A8K3G1
    • O60648
    • Q8TBG8
    • Q96T69

    Protein attributes for SPRYD7 Gene

    Size:
    196 amino acids
    Molecular mass:
    21666 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC09363.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPRYD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPRYD7 Gene

Post-translational modifications for SPRYD7 Gene

  • Ubiquitination at posLast=8585
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD7 Gene

No data available for DME Specific Peptides for SPRYD7 Gene

Domains & Families for SPRYD7 Gene

Gene Families for SPRYD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPRYD7 Gene

Suggested Antigen Peptide Sequences for SPRYD7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRYD7: view

No data available for UniProtKB/Swiss-Prot for SPRYD7 Gene

Function for SPRYD7 Gene

Phenotypes From GWAS Catalog for SPRYD7 Gene

Gene Ontology (GO) - Molecular Function for SPRYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPRYD7: view
genes like me logo Genes that share phenotypes with SPRYD7: view

Animal Model Products

CRISPR Products

miRNA for SPRYD7 Gene

miRTarBase miRNAs that target SPRYD7

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD7 Gene

Localization for SPRYD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD7 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD7 Gene

Pathways & Interactions for SPRYD7 Gene

SuperPathways for SPRYD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPRYD7 Gene

Drugs & Compounds for SPRYD7 Gene

No Compound Related Data Available

Transcripts for SPRYD7 Gene

Unigene Clusters for SPRYD7 Gene

SPRY domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for SPRYD7 Gene

GeneLoc Exon Structure for
SPRYD7
ECgene alternative splicing isoforms for
SPRYD7

Expression for SPRYD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRYD7 Gene

Protein differential expression in normal tissues from HIPED for SPRYD7 Gene

This gene is overexpressed in Placenta (13.2) and Bone (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPRYD7 Gene



Protein tissue co-expression partners for SPRYD7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRYD7 Gene:

SPRYD7

SOURCE GeneReport for Unigene cluster for SPRYD7 Gene:

Hs.44235

Evidence on tissue expression from TISSUES for SPRYD7 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with SPRYD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRYD7 Gene

Orthologs for SPRYD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRYD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRYD7 33 34
  • 99.66 (n)
oppossum
(Monodelphis domestica)
Mammalia SPRYD7 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPRYD7 33 34
  • 94.2 (n)
cow
(Bos Taurus)
Mammalia SPRYD7 33 34
  • 94.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPRYD7 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spryd7 33 16 34
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Spryd7 33
  • 90.48 (n)
chicken
(Gallus gallus)
Aves SPRYD7 33 34
  • 82.99 (n)
lizard
(Anolis carolinensis)
Reptilia SPRYD7 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd7 33
  • 80.28 (n)
Str.11085 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24473 33
zebrafish
(Danio rerio)
Actinopterygii spryd7b 34
  • 85 (a)
OneToMany
spryd7a 34 33
  • 74.49 (n)
OneToMany
Dr.13478 33
fruit fly
(Drosophila melanogaster)
Insecta CG7785 34 33
  • 53.68 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001349 33
  • 51.66 (n)
worm
(Caenorhabditis elegans)
Secernentea F18H3.1 33 34
  • 54.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for SPRYD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPRYD7 Gene

ENSEMBL:
Gene Tree for SPRYD7 (if available)
TreeFam:
Gene Tree for SPRYD7 (if available)

Paralogs for SPRYD7 Gene

Pseudogenes.org Pseudogenes for SPRYD7 Gene

genes like me logo Genes that share paralogs with SPRYD7: view

No data available for Paralogs for SPRYD7 Gene

Variants for SPRYD7 Gene

Sequence variations from dbSNP and Humsavar for SPRYD7 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000162391 -- 49,928,017(-) G/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000278009 -- 49,918,519(-) C/T intron_variant
rs1000363571 -- 49,936,528(-) T/A/C upstream_transcript_variant
rs1000470058 -- 49,927,490(-) T/A/C intron_variant
rs1000588049 -- 49,936,707(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD7 Gene

Variant ID Type Subtype PubMed ID
esv3632059 CNV loss 21293372
nsv561618 CNV loss 21841781

Variation tolerance for SPRYD7 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRYD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRYD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD7 Gene

Disorders for SPRYD7 Gene

Additional Disease Information for SPRYD7

No disorders were found for SPRYD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD7 Gene

Publications for SPRYD7 Gene

  1. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. (PMID: 11306461) Mabuchi H … Croce CM (Cancer research 2001) 2 3 4 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. [Transcription map of the 13q14 region, frequently deleted in B-cell chronic lymphocytic leukemia patients]. (PMID: 11771308) Tiazhelova TV … Baranova AV (Genetika 2001) 2 3 58
  5. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. (PMID: 28430825) Ng MCY … North KE (PLoS genetics 2017) 3 58

Products for SPRYD7 Gene

Sources for SPRYD7 Gene

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