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Aliases for SPRYD3 Gene

Aliases for SPRYD3 Gene

  • SPRY Domain Containing 3 2 3 5
  • SPRY Domain-Containing Protein 3 3 4

External Ids for SPRYD3 Gene

Previous GeneCards Identifiers for SPRYD3 Gene

  • GC12M051746
  • GC12M053458
  • GC12M050501

Summaries for SPRYD3 Gene

GeneCards Summary for SPRYD3 Gene

SPRYD3 (SPRY Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is RANBP9.

Additional gene information for SPRYD3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD3 Gene

Genomics for SPRYD3 Gene

GeneHancer (GH) Regulatory Elements for SPRYD3 Gene

Promoters and enhancers for SPRYD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053078 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 604.9 -0.3 -330 3.5 SP1 ZFX NKRF POLR2A MLLT1 GTF2F1 ZNF687 FOS AHR MAFK SPRYD3 ZNF740 SOAT2 TARBP2 EIF4B ENSG00000270175 NPFF RNU6-333P HOXC6 CSAD
GH12J052180 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.9 +891.0 890955 15.1 NFIB ZSCAN21 MAFK MYC SP7 POLR2A SP1 PRDM1 MZF1 EGR1 KRT80 ZNF740 HNRNPA3P10 CSAD ENSG00000257808 KRT7 POU6F1 SPRYD3 C12orf80 NR4A1
GH12J053498 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14 -421.1 -421131 5.1 HDGF ZFX SP1 CC2D1A ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF MAP3K12 ENSG00000270175 TARBP2 KRT1 ATF7 HNRNPA1 ZNF740 ENSG00000258344 PCBP2 CBX5
GH12J052894 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14 +176.5 176492 16.1 MTA3 ZNF652 ZFX CC2D1A SP1 ELF3 CTCF MNT CBFA2T2 ZNF148 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 LOC100652999 ENSG00000257808 ATF7 TARBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRYD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRYD3 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Lmo2
  • Nkx2-5
  • POU2F1
  • SRF
  • SRF (504 AA)

Genomic Locations for SPRYD3 Gene

Genomic Locations for SPRYD3 Gene
15,105 bases
Minus strand
15,105 bases
Minus strand

Genomic View for SPRYD3 Gene

Genes around SPRYD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD3 Gene

Proteins for SPRYD3 Gene

  • Protein details for SPRYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B9EG99
    • Q96SK5

    Protein attributes for SPRYD3 Gene

    442 amino acids
    Molecular mass:
    49694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPRYD3 Gene

neXtProt entry for SPRYD3 Gene

Post-translational modifications for SPRYD3 Gene

  • Ubiquitination at posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD3 Gene

No data available for DME Specific Peptides for SPRYD3 Gene

Domains & Families for SPRYD3 Gene

Gene Families for SPRYD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPRYD3 Gene

Suggested Antigen Peptide Sequences for SPRYD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53727, highly similar to SPRY domain-containing protein 3 (B7Z1Y3_HUMAN)
  • SPRY domain-containing protein 3 (SPRY3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRYD3: view

No data available for UniProtKB/Swiss-Prot for SPRYD3 Gene

Function for SPRYD3 Gene

Phenotypes From GWAS Catalog for SPRYD3 Gene

genes like me logo Genes that share phenotypes with SPRYD3: view

Animal Models for SPRYD3 Gene

MGI Knock Outs for SPRYD3:
  • Spryd3 Spryd3<tm1b(EUCOMM)Hmgu>
  • Spryd3 Spryd3<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPRYD3 - Now 50% OFF >
  • * SPRYD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPRYD3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRYD3 Gene

Localization for SPRYD3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD3 Gene

Pathways & Interactions for SPRYD3 Gene

PathCards logo

SuperPathways for SPRYD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRYD3 Gene

Drugs & Compounds for SPRYD3 Gene

No Compound Related Data Available

Transcripts for SPRYD3 Gene

mRNA/cDNA for SPRYD3 Gene

Unigene Clusters for SPRYD3 Gene

SPRY domain containing 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SPRYD3 - Now 50% OFF >
  • * SPRYD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SPRYD3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP4: -
SP5: -

Relevant External Links for SPRYD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRYD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRYD3 Gene

This gene is overexpressed in Placenta (20.0), Spleen (17.2), Ovary (10.2), CD4 Tcells (10.0), and CD8 Tcells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPRYD3 Gene

Protein tissue co-expression partners for SPRYD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPRYD3 Gene:


SOURCE GeneReport for Unigene cluster for SPRYD3 Gene:


Evidence on tissue expression from TISSUES for SPRYD3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SPRYD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRYD3 Gene

Orthologs for SPRYD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPRYD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SPRYD3 35 34
  • 93.97 (n)
(Bos Taurus)
Mammalia SPRYD3 35 34
  • 93.36 (n)
(Mus musculus)
Mammalia Spryd3 17 35 34
  • 92.99 (n)
(Rattus norvegicus)
Mammalia Spryd3 34
  • 92.99 (n)
(Pan troglodytes)
Mammalia SPRYD3 35 34
  • 92.01 (n)
(Ornithorhynchus anatinus)
Mammalia SPRYD3 35
  • 73 (a)
(Gallus gallus)
Aves SPRYD3 35 34
  • 80.33 (n)
(Anolis carolinensis)
Reptilia SPRYD3 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd3 34
  • 75.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30203 34
(Danio rerio)
Actinopterygii spryd3 35 34
  • 71.16 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6236 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 35
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for SPRYD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD3 Gene

Gene Tree for SPRYD3 (if available)
Gene Tree for SPRYD3 (if available)
Evolutionary constrained regions (ECRs) for SPRYD3: view image

Paralogs for SPRYD3 Gene

Paralogs for SPRYD3 Gene

genes like me logo Genes that share paralogs with SPRYD3: view

Variants for SPRYD3 Gene

Sequence variations from dbSNP and Humsavar for SPRYD3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000135073 -- 53,065,736(-) C/A 3_prime_UTR_variant
rs1000326967 -- 53,079,521(-) G/A/C/T upstream_transcript_variant
rs1000385419 -- 53,075,903(-) C/G intron_variant
rs1000774987 -- 53,080,812(-) A/C upstream_transcript_variant
rs1001211710 -- 53,075,297(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD3 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
nsv470294 CNV loss 18288195
nsv517066 CNV loss 19592680
nsv712 CNV insertion 18451855
nsv832417 CNV gain 17160897

Variation tolerance for SPRYD3 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRYD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD3 Gene

Disorders for SPRYD3 Gene

Additional Disease Information for SPRYD3

No disorders were found for SPRYD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD3 Gene

Publications for SPRYD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. (PMID: 29293652) Stockum A … Maertens GN (PloS one 2018) 3 58
  3. Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor. (PMID: 28276505) Kotani Y … Nagata K (Scientific reports 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. (PMID: 25720964) Kourtis N … Aifantis I (Nature cell biology 2015) 3 58

Products for SPRYD3 Gene

Sources for SPRYD3 Gene

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