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Aliases for SPRY4-IT1 Gene

Subcategory (RNA class) for SPRY4-IT1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for SPRY4-IT1 Gene

  • SPRY4 Intronic Transcript 1 2 3 5
  • SPRY4 Intronic Transcript 1 (Non-Protein Coding) 2 3

External Ids for SPRY4-IT1 Gene

Previous GeneCards Identifiers for SPRY4-IT1 Gene

  • GC05U901574

Summaries for SPRY4-IT1 Gene

Entrez Gene Summary for SPRY4-IT1 Gene

  • This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (sprouty RTK signaling antagonist 4). [provided by RefSeq, Feb 2016]

GeneCards Summary for SPRY4-IT1 Gene

SPRY4-IT1 (SPRY4 Intronic Transcript 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for SPRY4-IT1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY4-IT1 Gene

Genomics for SPRY4-IT1 Gene

GeneHancer (GH) Regulatory Elements for SPRY4-IT1 Gene

Promoters and enhancers for SPRY4-IT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I142314 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 0.8 -3.4 -3399 13.8 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SPRY4 LOC102723915 HDAC3 FCHSD1 KIAA0141 ENSG00000271871 RPL7P21 PCDHGA11 LINC01844 ENSG00000261757
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRY4-IT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPRY4-IT1 Gene

Genomic Locations for SPRY4-IT1 Gene
703 bases
Minus strand

Genomic View for SPRY4-IT1 Gene

Genes around SPRY4-IT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY4-IT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY4-IT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY4-IT1 Gene

Proteins for SPRY4-IT1 Gene

Post-translational modifications for SPRY4-IT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPRY4-IT1 Gene

Domains & Families for SPRY4-IT1 Gene

Gene Families for SPRY4-IT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRY4-IT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPRY4-IT1 Gene

Function for SPRY4-IT1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRY4-IT1 Gene

Localization for SPRY4-IT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRY4-IT1 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPRY4-IT1 Gene

Pathways & Interactions for SPRY4-IT1 Gene

SuperPathways for SPRY4-IT1 Gene

No Data Available

Interacting Proteins for SPRY4-IT1 Gene

Gene Ontology (GO) - Biological Process for SPRY4-IT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRY4-IT1 Gene

Drugs & Compounds for SPRY4-IT1 Gene

No Compound Related Data Available

Transcripts for SPRY4-IT1 Gene

mRNA/cDNA for SPRY4-IT1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY4-IT1 Gene

No ASD Table

Relevant External Links for SPRY4-IT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY4-IT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRY4-IT1 Gene

mRNA expression in normal human tissues for SPRY4-IT1 Gene

SOURCE GeneReport for Unigene cluster for SPRY4-IT1 Gene:

genes like me logo Genes that share expression patterns with SPRY4-IT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY4-IT1 Gene

Orthologs for SPRY4-IT1 Gene

Evolution for SPRY4-IT1 Gene

Gene Tree for SPRY4-IT1 (if available)
Gene Tree for SPRY4-IT1 (if available)

No data available for Orthologs for SPRY4-IT1 Gene

Paralogs for SPRY4-IT1 Gene

No data available for Paralogs for SPRY4-IT1 Gene

Variants for SPRY4-IT1 Gene

Sequence variations from dbSNP and Humsavar for SPRY4-IT1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000900820 -- 142,318,493(-) AAAAAAAGAAA/AAA upstream_transcript_variant
rs1001152851 -- 142,318,211(-) G/A non_coding_transcript_variant
rs1001438706 -- 142,317,874(-) G/A non_coding_transcript_variant
rs1001533779 -- 142,319,201(-) G/A upstream_transcript_variant
rs1001649910 -- 142,319,558(-) G/A upstream_transcript_variant

Additional Variant Information for SPRY4-IT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SPRY4-IT1 Gene

Disorders for SPRY4-IT1 Gene

Additional Disease Information for SPRY4-IT1

No disorders were found for SPRY4-IT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRY4-IT1 Gene

Publications for SPRY4-IT1 Gene

  1. The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes. (PMID: 26829028) Zhao W … Perera RJ (The Journal of investigative dermatology 2016) 2 3 58
  2. The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells. (PMID: 25344859) Mazar J … Perera RJ (Oncotarget 2014) 2 3 58
  3. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. (PMID: 21558391) Khaitan D … Perera RJ (Cancer research 2011) 2 3 58
  4. Effects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. (PMID: 28796375) Wen X … Zheng YL (Journal of cellular biochemistry 2018) 3 58
  5. LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer. (PMID: 29234152) Zhou H … Zhou X (Cancer gene therapy 2018) 3 58

Products for SPRY4-IT1 Gene

Sources for SPRY4-IT1 Gene

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