Aliases for SPRY4 Gene
External Ids for SPRY4 Gene
Previous GeneCards Identifiers for SPRY4 Gene
This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for SPRY4 Gene
SPRY4 (Sprouty RTK Signaling Antagonist 4) is a Protein Coding gene. Diseases associated with SPRY4 include Hypogonadotropic Hypogonadism 17 With Or Without Anosmia and Kallmann Syndrome. An important paralog of this gene is SPRY1.
UniProtKB/Swiss-Prot Summary for SPRY4 Gene
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898).