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Aliases for SPRY3 Gene

Aliases for SPRY3 Gene

  • Sprouty RTK Signaling Antagonist 3 2 3 5
  • Antagonist Of FGF Signaling 2 3
  • Spry-3 3 4
  • Sprouty (Drosophila) Homolog 2 2
  • Sprouty Homolog 3 (Drosophila) 2
  • Protein Sprouty Homolog 3 3
  • Sprouty Homolog 3 3

External Ids for SPRY3 Gene

Previous GeneCards Identifiers for SPRY3 Gene

  • GC00U990472
  • GC0YM050220
  • GC0XP153429
  • GC0YP057438
  • GC0XP154561
  • GC0XP154650
  • GC0XP154997
  • GC0XP143477

Summaries for SPRY3 Gene

GeneCards Summary for SPRY3 Gene

SPRY3 (Sprouty RTK Signaling Antagonist 3) is a Protein Coding gene. Diseases associated with SPRY3 include Legius Syndrome and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. An important paralog of this gene is SPRY2.

UniProtKB/Swiss-Prot for SPRY3 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Gene Wiki entry for SPRY3 Gene

Additional gene information for SPRY3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY3 Gene

Genomics for SPRY3 Gene

GeneHancer (GH) Regulatory Elements for SPRY3 Gene

Promoters and enhancers for SPRY3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI155611 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.3 1312 2.4 ATF1 SIN3A DMAP1 ZNF2 ZNF48 GLIS2 KLF7 ATF7 SP3 ZNF518A TMLHE SPRY3 GC0XM155612 TMLHE-AS1
GH0XI155766 Promoter 1.6 EPDnew Ensembl 550.1 +156.8 156751 1.8 HDAC1 HDGF ZNF493 INSM2 KLF17 MZF1 NFXL1 ZNF2 ZNF335 ZNF366 SPRY3 GC0XM155829 PIR37449
GH0XI155641 Enhancer 0.7 Ensembl 0.3 +30.9 30850 0.8 HDAC1 LEF1 ETV1 ZBTB40 E2F1 ZSCAN29 TRIM24 SMARCE1 AFF1 SOX6 TMLHE GC0XM155612 SPRY3
GH0XI155632 Enhancer 0.6 Ensembl ENCODE 0.3 +21.7 21729 1 IRF2 FOXK2 NFE2 TMLHE GC0XM155612 SPRY3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRY3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRY3 gene promoter:

Genomic Locations for SPRY3 Gene

Genomic Locations for SPRY3 Gene
171,510 bases
Plus strand

Genomic View for SPRY3 Gene

Genes around SPRY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY3 Gene

Proteins for SPRY3 Gene

  • Protein details for SPRY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sprouty homolog 3
    Protein Accession:
    Secondary Accessions:
    • A8K0H8

    Protein attributes for SPRY3 Gene

    288 amino acids
    Molecular mass:
    31222 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
    • Sequence=AAC39567.1; Type=Frameshift; Positions=96; Evidence={ECO:0000305};

neXtProt entry for SPRY3 Gene

Post-translational modifications for SPRY3 Gene

No Post-translational modifications

Other Protein References for SPRY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRY3 Gene

Domains & Families for SPRY3 Gene

Gene Families for SPRY3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SPRY3 Gene


Suggested Antigen Peptide Sequences for SPRY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY3: view

Function for SPRY3 Gene

Molecular function for SPRY3 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
UniProtKB/Swiss-Prot Induction:
By FGF signaling.

Phenotypes From GWAS Catalog for SPRY3 Gene

Gene Ontology (GO) - Molecular Function for SPRY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPRY3: view
genes like me logo Genes that share phenotypes with SPRY3: view

Clone Products

  • Addgene plasmids for SPRY3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRY3 Gene

Localization for SPRY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY3 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRY3 gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRY3: view

Pathways & Interactions for SPRY3 Gene

SuperPathways for SPRY3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 9458049
GO:0009966 regulation of signal transduction IEA --
GO:0061564 axon development IEA --
genes like me logo Genes that share ontologies with SPRY3: view

No data available for Pathways by source and SIGNOR curated interactions for SPRY3 Gene

Drugs & Compounds for SPRY3 Gene

No Compound Related Data Available

Transcripts for SPRY3 Gene

mRNA/cDNA for SPRY3 Gene

Unigene Clusters for SPRY3 Gene

Sprouty homolog 3 (Drosophila):
Representative Sequences:

Clone Products

  • Addgene plasmids for SPRY3

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY3 Gene

No ASD Table

Relevant External Links for SPRY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SPRY3 Gene:


SOURCE GeneReport for Unigene cluster for SPRY3 Gene:


mRNA Expression by UniProt/SwissProt for SPRY3 Gene:

Tissue specificity: Widely expressed; particularly in the fetal tissues.

Evidence on tissue expression from TISSUES for SPRY3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SPRY3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY3 Gene

Orthologs for SPRY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRY3 33
  • 99.65 (n)
(Canis familiaris)
Mammalia SPRY3 33
  • 95.25 (n)
(Bos Taurus)
Mammalia SPRY3 33 34
  • 92.59 (n)
(Mus musculus)
Mammalia Spry3 33 16 34
  • 91.67 (n)
(Rattus norvegicus)
Mammalia Spry3 33
  • 83.81 (n)
(Monodelphis domestica)
Mammalia SPRY3 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SPRY3 34
  • 57 (a)
(Gallus gallus)
Aves SPRY3 33 34
  • 70.94 (n)
(Anolis carolinensis)
Reptilia SPRY3 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spry3 33
  • 63.73 (n)
(Danio rerio)
Actinopterygii LOC100003704 33
  • 62.26 (n)
wufk66h11 33
fruit fly
(Drosophila melanogaster)
Insecta sty 34
  • 16 (a)
Species where no ortholog for SPRY3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY3 Gene

Gene Tree for SPRY3 (if available)
Gene Tree for SPRY3 (if available)

Paralogs for SPRY3 Gene

Paralogs for SPRY3 Gene

(3) SIMAP similar genes for SPRY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPRY3: view

Variants for SPRY3 Gene

Sequence variations from dbSNP and Humsavar for SPRY3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs779201129 uncertain-significance, Ependymoma 56,960,446(+) C/T coding_sequence_variant, missense_variant
rs1000029487 -- 56,963,938(+) C/A 3_prime_UTR_variant
rs1000050113 -- 155,645,623(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000149416 -- 56,919,109(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000163025 -- 155,674,620(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRY3 Gene

Variant ID Type Subtype PubMed ID
nsv471607 CNV gain+loss 15918152
esv2657377 CNV deletion 23128226

Variation tolerance for SPRY3 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRY3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY3 Gene

Disorders for SPRY3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPRY3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome; nfls
immunodeficiency-centromeric instability-facial anomalies syndrome
  • immune deficiency, variable, with centromeric instability of chromosomes 1, 9, and 16
- elite association - COSMIC cancer census association via MalaCards
Search SPRY3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPRY3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPRY3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRY3 Gene

Publications for SPRY3 Gene

  1. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N … Krasnow MA (Cell 1998) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PMID: 10655549) Ciccodicola A … D'Urso M (Human molecular genetics 2000) 3 4 58
  5. Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. (PMID: 26089202) Ning Z … Moore T (Human molecular genetics 2015) 3 58

Products for SPRY3 Gene

Sources for SPRY3 Gene

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