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This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
SPRY2 (Sprouty RTK Signaling Antagonist 2) is a Protein Coding gene. Diseases associated with SPRY2 include Iga Nephropathy 3 and Adrenal Cortical Adenocarcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12815057 |
GO:0019901 | protein kinase binding | IPI | 20736167 |
GO:0030291 | protein serine/threonine kinase inhibitor activity | IC | 20736167 |
GO:0043539 | protein serine/threonine kinase activator activity | IMP | 18070883 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | ISS,TAS | -- |
GO:0005856 | cytoskeleton | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Negative regulation of FGFR3 signaling | ||
2 | Signaling by FGFR2 | ||
3 | MAP Kinase Signaling | ||
4 | Tyrosine Kinases / Adaptors | ||
5 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000132 | establishment of mitotic spindle orientation | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007605 | sensory perception of sound | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IEA | -- |
GO:0009966 | regulation of signal transduction | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||
SP2: | - | - | - | ||||||||||||
SP3: | - | ||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Spry2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Spry2 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SPRY2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SPRY2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SPRY2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SPRY2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spry2 30 |
|
||
Str.92 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398313 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | spry2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | sty 31 32 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs869025336 | Risk Factor: IgA nephropathy, susceptibility to, 3. IgA nephropathy 3 (IGAN3) [MIM:616818] | 80,337,351(-) | G/Ap.Arg119Trp | MISSENSE_VARIANT | |
rs504122 | - | p.Pro106Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2747714 | CNV | deletion | 23290073 |
esv3632829 | CNV | gain | 21293372 |
nsv819288 | CNV | loss | 19587683 |
nsv832660 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
iga nephropathy 3 |
|
|
adrenal cortical adenocarcinoma |
|
|
thanatophoric dysplasia, type ii |
|
|
achondroplasia |
|
|
legius syndrome |
|
|