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This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregula... See more...
Aliases for SPRY2 Gene
Aliases for SPRY2 Gene
External Ids for SPRY2 Gene
- HGNC: 11270
- NCBI Entrez Gene: 10253
- Ensembl: ENSG00000136158
- OMIM®: 602466
- UniProtKB/Swiss-Prot: O43597
Previous GeneCards Identifiers for SPRY2 Gene
- GC13M078877
- GC13M074905
- GC13M079846
- GC13M078708
- GC13M079808
- GC13M080910
- GC13M061613
Summaries for SPRY2 Gene
-
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPRY2 Gene
SPRY2 (Sprouty RTK Signaling Antagonist 2) is a Protein Coding gene. Diseases associated with SPRY2 include Iga Nephropathy 3 and Adrenal Cortical Adenocarcinoma. Among its related pathways are Signaling by GPCR and Negative regulation of FGFR1 signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY1.
UniProtKB/Swiss-Prot Summary for SPRY2 Gene
-
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).
Additional gene information for SPRY2 Gene
- HGNC (11270)
- NCBI Entrez Gene (10253)
- Ensembl (ENSG00000136158)
- OMIM® (602466)
- UniProtKB/Swiss-Prot (O43597)
- Open Targets Platform(ENSG00000136158)
- Monarch Initiative
- Search for SPRY2 at DataMed
- Search for SPRY2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRY2 Gene
Genomics for SPRY2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SPRY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPRY2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRY2
- Top Transcription factor binding sites by QIAGEN in the SPRY2 gene promoter:
-
- MZF-1
- Nkx2-5
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- SREBP-1b
Genomic Locations for SPRY2 Gene
Latest Assembly
- chr13:80,335,976-80,341,126
- (GRCh38/hg38)
- Size:
- 5,151 bases
- Orientation:
- Minus strand
Previous Assembly
- chr13:80,910,111-80,915,261
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,151 bases
- Orientation:
- Minus strand
- chr13:80,910,111-80,915,086
- (GRCh37/hg19 by Ensembl)
- Size:
- 4,976 bases
- Orientation:
- Minus strand
Genomic View for SPRY2 Gene
Genes around SPRY2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q31.1 by HGNC
- 13q31.1 by Entrez Gene
- 13q31.1 by Ensembl
SPRY2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPRY2 Gene
Proteins for SPRY2 Gene
-
Protein details for SPRY2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43597-SPY2_HUMAN
- Recommended name:
- Protein sprouty homolog 2
- Protein Accession:
- O43597
- B2R9J9
- Q5T6Z7
Protein attributes for SPRY2 Gene
- Size:
- 315 amino acids
- Molecular mass:
- 34688 Da
- Quaternary structure:
-
- Forms heterodimers with SPRY1 (By similarity). Part of a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Interacts with METTL13 (PubMed:29408807).Interacts with RAF1 (PubMed:12717443). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation (PubMed:17974561). Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2 (PubMed:17974561). Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2 (PubMed:17974561). Interacts with GRB2 (PubMed:17974561). Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR (PubMed:17974561). Interacts (via C-terminus) with CAV1 (via C-terminus) (PubMed:16877379).
Protein Expression for SPRY2 Gene
Post-translational modifications for SPRY2 Gene
- Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SPRY2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SPRY2 / Sprouty 2 Antibody (LS-B5819) and SPRY2 / Sprouty 2 Antibody (LS-B10618)
- Novus Biologicals Antibodies for SPRY2
- Invitrogen Antibodies for SPRY2 (AFLGC-SPRY2)
-
Biorbyt antibodies for SPRY2
-
Custom Antibody ServicesProSci Antibodies for SPRY2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPRY2
- Sino Biological Antibodies for SPRY2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRY2
- Origene Custom Protein Services for SPRY2
-
Abcam proteins for SPRY2
Assay products for research
No data available for DME Specific Peptides for SPRY2 Gene
Domains & Families for SPRY2 Gene
Gene Families for SPRY2 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for SPRY2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein sprouty homolog 2 (SPY2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43597UniProtKB/Swiss-Prot:
SPY2_HUMAN :- The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
- Belongs to the sprouty family.
- Domain:
-
- The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
- Family:
-
- Belongs to the sprouty family.
Function for SPRY2 Gene
Molecular function for SPRY2 Gene
- UniProtKB/Swiss-Prot Function:
- Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).
Phenotypes From GWAS Catalog for SPRY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12815057 |
| GO:0019901 | protein kinase binding | IPI | 20736167 |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | IC | 20736167 |
| GO:0043539 | protein serine/threonine kinase activator activity | IMP | 18070883 |
Phenotypes for SPRY2 Gene
- MGI mutant phenotypes for SPRY2:
-
inferred from 3 alleles
- nervous system phenotype
- growth/size/body region phenotype
- respiratory system phenotype
- mortality/aging
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for SPRY2:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SPRY2 - Starting at $85 >
- * SPRY2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SPRY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRY2
miRNA for SPRY2 Gene
- miRTarBase miRNAs that target SPRY2
-
- hsa-miR-21-5p (MIRT000672)
- mmu-miR-21a-5p (MIRT001018)
- hsa-miR-27a-3p (MIRT005511)
- hsa-miR-124-3p (MIRT022159)
- hsa-miR-1-3p (MIRT023487)
- hsa-miR-181a-5p (MIRT025117)
- hsa-miR-148a-3p (MIRT025980)
- hsa-miR-26b-5p (MIRT028756)
- dre-miR-21 (MIRT053111)
- hsa-miR-24-2-5p (MIRT438902)
- hsa-miR-23a-3p (MIRT438903)
- hsa-miR-122-5p (MIRT733104)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRY2
- Browse OriGene Inhibitory RNA Products For SPRY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRY2
Clone products for research
- Applied Biological Materials (abm): Clones for SPRY2 - Starting at $45 >
- * SPRY2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SPRY2
- Addgene plasmids for SPRY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRY2
Cell Lines for research
-
Horizon Cell Lines for SPRY2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPRY2 Gene
Localization for SPRY2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPRY2 Gene
- Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). {ECO:0000269 PubMed:10887178}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Actin filaments (3)
- Microtubules (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | ISS,TAS | -- |
| GO:0005856 | cytoskeleton | ISS | -- |
| GO:0005874 | microtubule | IEA | -- |
Pathways & Interactions for SPRY2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Negative regulation of FGFR1 signaling | ||
| 2 | Signaling by FGFR2 | ||
| 3 | MAP Kinase Signaling | ||
| 4 | Tyrosine Kinases / Adaptors | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for SPRY2 Gene
6 BioSystems pathways for SPRY2 Gene
1 KEGG pathway for SPRY2 Gene
2 Cell Signaling Technology pathways for SPRY2 Gene
Interacting Proteins for SPRY2 Gene
Selected Interacting proteins:
O43597-SPY2_HUMAN
ENSP00000366306
for SPRY2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SPRY2
SIGNOR curated interactions for SPRY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000132 | establishment of mitotic spindle orientation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007605 | sensory perception of sound | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0009966 | regulation of signal transduction | IEA | -- |
Transcripts for SPRY2 Gene
mRNA/cDNA for SPRY2 Gene
- 4 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377102 2708 nts (view in UCSC)
- ENST00000377104 2286 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SPRY2 - Starting at $85 >
- * SPRY2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SPRY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRY2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRY2
- Browse OriGene Inhibitory RNA Products For SPRY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRY2
Clone products for research
- Applied Biological Materials (abm): Clones for SPRY2 - Starting at $45 >
- * SPRY2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SPRY2
- Addgene plasmids for SPRY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRY2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||
| SP2: | - | - | - | ||||||||||||
| SP3: | - | ||||||||||||||
| SP4: |
Relevant External Links for SPRY2 Gene
- GeneLoc Exon Structure for
- SPRY2
Expression for SPRY2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Tendon Progenitor Cells Syndetome
- Mononuclear Myocytes Cervical Epaxial Myotome
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
- Mononuclear Myocytes Cervical Hypaxial Myotome
-
Eye (Sensory Organs)
- Lens Placode Cells Lens Placode
- Primary Lens Fiber Cells Lens
- Lens Pit Cells Lens Pit
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Cervical Epaxial Myotome
- Mononuclear Myocytes Cervical Hypaxial Myotome
-
Placenta (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Chorion (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Tendon & Ligament
- Tendon Progenitor Cells Syndetome
-
Neural Ectoderm (Nervous System)
- Isthmus Cells Neural Plate
-
Neural Tube (Nervous System)
- Isthmus Cells Neural Plate
-
Primitive Streak (Early Embryonic Tissues)
- Primitive Streak Cells Primitive Streak
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Presegmented Somitic Mesenchyme Cells Presomitic Mesoderm
-
Lung (Respiratory System)
- Distal Lung Progenitor Cells Lung Bud
-
Tooth (Integumentary System)
- Stellate Reticulum Cells Dental Core
- Epithelial Cells
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
-
Ovary (Reproductive System)
This gene is overexpressed in Pancreas (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRY2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRY2
SOURCE GeneReport for Unigene cluster for SPRY2 Gene:
Hs.18676Evidence on tissue expression from TISSUES for SPRY2 Gene
- Nervous system(4.7)
- Skin(4.5)
- Muscle(2.5)
- Heart(2.4)
- Lung(2.4)
- Intestine(2.2)
- Liver(2.2)
- Kidney(2.1)
- Pancreas(2.1)
- Thyroid gland(2)
Primer products for research
-
OriGene qPCR primer pairs for SPRY2
-
OriGene qPCR primer pairs and template standards for SPRY2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY2 Gene
Orthologs for SPRY2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Spry2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Spry2 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SPRY2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SPRY2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SPRY2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SPRY2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SPRY2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spry2 30 |
|
||
| Str.92 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398313 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | spry2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | sty 31 32 |
|
OneToMany |
- Species where no ortholog for SPRY2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SPRY2 Gene
- ENSEMBL:
- Gene Tree for SPRY2 (if available)
- TreeFam:
- Gene Tree for SPRY2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPRY2: view image
Paralogs for SPRY2 Gene
Variants for SPRY2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRY2 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869025336 | Risk Factor: IgA nephropathy, susceptibility to, 3. IgA nephropathy 3 (IGAN3) [MIM:616818] | 80,337,351(-) |
G/Ap.Arg119Trp NM_005842.4(SPRY2):c.355C>T (p.Arg119Trp) |
MISSENSE | |
| rs504122 | - |
p.Pro106Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2747714 | CNV | deletion | 23290073 |
| esv3632829 | CNV | gain | 21293372 |
| nsv819288 | CNV | loss | 19587683 |
| nsv832660 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.12;
80.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPRY2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY2 Gene
Disorders for SPRY2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| iga nephropathy 3 |
|
|
| adrenal cortical adenocarcinoma |
|
|
| thanatophoric dysplasia, type ii |
|
|
| achondroplasia |
|
|
| legius syndrome |
|
|
Search SPRY2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SPY2_HUMAN- IgA nephropathy 3 (IGAN3) [MIM:616818]: A form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations. {ECO:0000269 PubMed:25782674}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Additional Disease Information for SPRY2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for SPRY2 Gene
Publications for SPRY2 Gene
- A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy. (PMID: 25782674) Milillo A … Sangiorgi E (European journal of human genetics : EJHG 2015) 3 4 74
- Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. (PMID: 10887178) Lim J … Guy GR (The Journal of biological chemistry 2000) 3 4 23
- sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N … Krasnow MA (Cell 1998) 2 3 4
- Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. (PMID: 29408807) Yousaf R … Riazuddin S (The Journal of clinical investigation 2018) 3 4
- Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate. (PMID: 21288888) Huang CH … Chen X (Journal of biochemistry 2011) 3 4
ExternalLinks
Products for SPRY2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRY2
- Origene Custom Protein Services for SPRY2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRY2
- Browse OriGene Inhibitory RNA Products For SPRY2
- OriGene qPCR primer pairs for SPRY2
- OriGene qPCR primer pairs and template standards for SPRY2
- OriGene CRISPR knockouts for SPRY2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPRY2
- Sino Biological Human cDNA Clone for SPRY2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for SPRY2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPRY2
- Novus Biologicals proteins and lysates for SPRY2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SPRY2
- Find your target
- Browse Primary Antibodies
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- Browse Secondary Antibodies
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- Browse Proteins and Peptides
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SPRY2 (AFLGC-SPRY2)
- VectorBuilder Custom and pre-made DNA vectors for SPRY2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SPRY2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SPRY2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SPRY2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SPRY2
- Addgene plasmids for SPRY2
- antibodies-online: Show 32 available SPRY2 Antibodies ranked by validation data
- Compare Top SPRY2 Antibodies
- antibodies-online: Search results for available SPRY2 related products ranked by validation data
- antibodies-online: Show 13 available SPRY2 Proteins ranked by validation data
- Compare Top SPRY2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SPRY2
- Search Santa Cruz Biotechnology (SCBT) for SPRY2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPRY2
- Horizon Cell Lines for SPRY2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRY2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SPRY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRY2
- Biorbyt antibodies for SPRY2
Sources for SPRY2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB