Aliases for SPRY1 Gene

Aliases for SPRY1 Gene

  • Sprouty RTK Signaling Antagonist 1 2 3 5
  • Protein Sprouty Homolog 1 3 4
  • Spry-1 3 4
  • Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) 3
  • Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling 3
  • HSPRY1 3

External Ids for SPRY1 Gene

Previous GeneCards Identifiers for SPRY1 Gene

  • GC04P125233
  • GC04P124600
  • GC04P124713
  • GC04P124779
  • GC04P124776
  • GC04P124675
  • GC04P124317
  • GC04P120044

Summaries for SPRY1 Gene

GeneCards Summary for SPRY1 Gene

SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are Listeria monocytogenes entry into host cells and Signaling by GPCR. An important paralog of this gene is SPRY2.

UniProtKB/Swiss-Prot Summary for SPRY1 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Gene Wiki entry for SPRY1 Gene

Additional gene information for SPRY1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRY1 Gene

Genomics for SPRY1 Gene

GeneHancer (GH) Regulatory Elements for SPRY1 Gene

Promoters and enhancers for SPRY1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J123396 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 754.9 +6.6 6617 14.6 SIN3A SP1 CTCF MLX RBPJ POLR2A NR2F6 ATF1 CREB1 MIXL1 SPRY1 FGF2 lnc-SPATA5-7 lnc-NUDT6-6
GH04J123395 Enhancer 0.2 dbSUPER 750.6 -1.1 -1053 0.6 SPRY1 lnc-SPATA5-7 HSALNG0036885
GH04J123504 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 12.5 +108.9 108879 3.2 MLX RBPJ NR2F6 MIXL1 ZNF362 L3MBTL2 POU5F1 RERE ELF3 AHR LINC02435 piR-57288 SPRY1 ENSG00000249125 LINC01091
GH04J123348 Enhancer 1.1 Ensembl ENCODE 19.4 -46.9 -46867 2.4 CTCF SMARCE1 RUNX1 CC2D1A ELF1 HLF RBM39 RAD21 TEAD4 ZC3H8 ENSG00000287951 SPATA5 SPRY1 NUDT6 LINC01091 HSALNG0036885 RF00994-766
GH04J123442 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 14 +47.1 47109 2.2 RBPJ SMARCE1 NR2F1 NR2F6 MIXL1 MYC TEAD4 ZNF148 RERE ELF3 lnc-NUDT6-6 SPRY1 lnc-SPATA5-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRY1 gene promoter:
  • AREB6
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1

Genomic Locations for SPRY1 Gene

Genomic Locations for SPRY1 Gene
6,970 bases
Plus strand
6,961 bases
Plus strand

Genomic View for SPRY1 Gene

Genes around SPRY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY1 Gene

Proteins for SPRY1 Gene

  • Protein details for SPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sprouty homolog 1
    Protein Accession:
    Secondary Accessions:
    • D3DNX6
    • Q6PNE0

    Protein attributes for SPRY1 Gene

    319 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRY1 Gene

Post-translational modifications for SPRY1 Gene

  • Ubiquitination at Lys167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPRY1 Gene

Domains & Families for SPRY1 Gene

Gene Families for SPRY1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRY1 Gene


Suggested Antigen Peptide Sequences for SPRY1 Gene

GenScript: Design optimal peptide antigens:
  • Protein sprouty homolog 1 (SPY1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY1: view

Function for SPRY1 Gene

Molecular function for SPRY1 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
UniProtKB/Swiss-Prot Induction:
By FGF signaling.

Phenotypes From GWAS Catalog for SPRY1 Gene

Gene Ontology (GO) - Molecular Function for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with SPRY1: view
genes like me logo Genes that share phenotypes with SPRY1: view

Animal Models for SPRY1 Gene

MGI Knock Outs for SPRY1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for SPRY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRY1 Gene

Localization for SPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRY1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
golgi apparatus 4
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS,ISS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SPRY1: view

Pathways & Interactions for SPRY1 Gene

genes like me logo Genes that share pathways with SPRY1: view

Pathways by source for SPRY1 Gene

3 Reactome pathways for SPRY1 Gene
3 Cell Signaling Technology pathways for SPRY1 Gene

SIGNOR curated interactions for SPRY1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001759 organ induction IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SPRY1: view

Drugs & Compounds for SPRY1 Gene

No Compound Related Data Available

Transcripts for SPRY1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for SPRY1

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY1 Gene

No ASD Table

Relevant External Links for SPRY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.7) and Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for SPRY1 Gene

This gene is overexpressed in Breast (61.4) and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRY1 Gene

Protein tissue co-expression partners for SPRY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRY1 Gene:


SOURCE GeneReport for Unigene cluster for SPRY1 Gene:


Evidence on tissue expression from TISSUES for SPRY1 Gene

  • Nervous system(4.4)
  • Heart(2.6)
  • Lung(2.4)
  • Muscle(2.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with SPRY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY1 Gene

Orthologs for SPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRY1 33 32
  • 99.69 (n)
(Canis familiaris)
Mammalia SPRY1 33 32
  • 94.15 (n)
(Bos Taurus)
Mammalia SPRY1 33 32
  • 93.42 (n)
(Mus musculus)
Mammalia Spry1 17 33 32
  • 82.96 (n)
(Monodelphis domestica)
Mammalia SPRY1 33
  • 67 (a)
(Gallus gallus)
Aves SPRY1 32
  • 80.29 (n)
(Anolis carolinensis)
Reptilia SPRY1 33
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spry1 32
  • 75.39 (n)
Str.10330 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.10087 32
(Danio rerio)
Actinopterygii spry1 33 32
  • 59.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta sty 33 34
  • 16 (a)
Species where no ortholog for SPRY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY1 Gene

Gene Tree for SPRY1 (if available)
Gene Tree for SPRY1 (if available)
Evolutionary constrained regions (ECRs) for SPRY1: view image

Paralogs for SPRY1 Gene

Paralogs for SPRY1 Gene

(3) SIMAP similar genes for SPRY1 Gene using alignment to 5 proteins:

  • L8E896_HUMAN
genes like me logo Genes that share paralogs with SPRY1: view

Variants for SPRY1 Gene

Sequence variations from dbSNP and Humsavar for SPRY1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000475492 -- 123,399,887(+) A/C intron_variant
rs1000789776 -- 123,398,904(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001285453 -- 123,399,506(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002110121 -- 123,403,377(+) C/T 3_prime_UTR_variant
rs1002197646 -- 123,397,351(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRY1 Gene

Variant ID Type Subtype PubMed ID
esv2759280 CNV gain 17122850
esv34581 CNV gain 17911159
esv3602044 CNV gain 21293372
nsv10562 CNV gain+loss 18304495

Variation tolerance for SPRY1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRY1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY1 Gene

Disorders for SPRY1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPRY1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
legius syndrome
  • lgss
- elite association - COSMIC cancer census association via MalaCards
Search SPRY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPRY1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPRY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRY1 Gene

Publications for SPRY1 Gene

  1. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N … Krasnow MA (Cell 1998) 2 3 4 56
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 43 56
  3. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PMID: 15962011) Haglund K … Dikic I (EMBO reports 2005) 2 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PMID: 14533010) Wang L … Mao Y (International journal of molecular medicine 2003) 3 4 56

Products for SPRY1 Gene

Sources for SPRY1 Gene