Aliases for SPRY1 Gene

Aliases for SPRY1 Gene

  • Sprouty RTK Signaling Antagonist 1 2 3 5
  • Protein Sprouty Homolog 1 3 4
  • HSPRY1 2 3
  • Spry-1 3 4
  • Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) 3
  • Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling 3
  • SPRY1 5

External Ids for SPRY1 Gene

Previous GeneCards Identifiers for SPRY1 Gene

  • GC04P125233
  • GC04P124600
  • GC04P124713
  • GC04P124779
  • GC04P124776
  • GC04P124675
  • GC04P124317
  • GC04P120044

Summaries for SPRY1 Gene

GeneCards Summary for SPRY1 Gene

SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is SPRY2.

UniProtKB/Swiss-Prot Summary for SPRY1 Gene

  • Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Gene Wiki entry for SPRY1 Gene

Additional gene information for SPRY1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRY1 Gene

Genomics for SPRY1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPRY1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J123396 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 604.9 +6.6 6613 14.6 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 SPRY1 FGF2 lnc-SPATA5-7 lnc-NUDT6-6
GH04J123395 Enhancer 0.2 dbSUPER 600.7 -1.1 -1057 0.6 SPRY1 lnc-SPATA5-7 ENSG00000287951 SPATA5
GH04J123504 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 +108.9 108875 3.2 HNRNPL GATAD2A PRDM10 TFE3 SOX13 NFKBIZ ZNF692 RCOR2 FOXA1 RBFOX2 LINC02435 piR-57288 SPRY1 ENSG00000249125 LINC01091
GH04J123647 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +254.1 254128 6.1 GATAD2A PRDM10 RFX1 SOX13 NFRKB BACH1 FOXA1 POLR2A TCF12 BRD4 LINC01091 SPRY1 piR-36588-328 lnc-SPRY1-4
GH04J123442 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 14 +47.1 47105 2.2 GATAD2A TEAD4 TFE3 SOX13 RCOR2 RBFOX2 RXRB IKZF2 HDAC1 ETV6 lnc-NUDT6-6 SPRY1 lnc-SPATA5-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRY1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRY1

Top Transcription factor binding sites by QIAGEN in the SPRY1 gene promoter:
  • AREB6
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1

Genomic Locations for SPRY1 Gene

Genomic Locations for SPRY1 Gene
chr4:123,396,795-123,403,760
(GRCh38/hg38)
Size:
6,966 bases
Orientation:
Plus strand
chr4:124,317,950-124,324,910
(GRCh37/hg19)
Size:
6,961 bases
Orientation:
Plus strand

Genomic View for SPRY1 Gene

Genes around SPRY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY1 Gene

Proteins for SPRY1 Gene

  • Protein details for SPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43609-SPY1_HUMAN
    Recommended name:
    Protein sprouty homolog 1
    Protein Accession:
    O43609
    Secondary Accessions:
    • D3DNX6
    • Q6PNE0

    Protein attributes for SPRY1 Gene

    Size:
    319 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRY1 Gene

Post-translational modifications for SPRY1 Gene

  • Ubiquitination at Lys167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPRY1 Gene

Domains & Families for SPRY1 Gene

Gene Families for SPRY1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRY1 Gene

InterPro:
Blocks:
  • Sprouty
ProtoNet:

Suggested Antigen Peptide Sequences for SPRY1 Gene

GenScript: Design optimal peptide antigens:
  • Protein sprouty homolog 1 (SPY1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43609

UniProtKB/Swiss-Prot:

SPY1_HUMAN :
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
Domain:
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
Family:
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY1: view

Function for SPRY1 Gene

Molecular function for SPRY1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SPRY1 Gene

Gene Ontology (GO) - Molecular Function for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with SPRY1: view
genes like me logo Genes that share phenotypes with SPRY1: view

Animal Models for SPRY1 Gene

MGI Knock Outs for SPRY1:

Animal Model Products

CRISPR Products

miRNA for SPRY1 Gene

miRTarBase miRNAs that target SPRY1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRY1

Clone Products

  • Addgene plasmids for SPRY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRY1 Gene

Localization for SPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY1 Gene

Cytoplasm. Membrane. Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRY1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
golgi apparatus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol ISS,TAS --
genes like me logo Genes that share ontologies with SPRY1: view

Pathways & Interactions for SPRY1 Gene

genes like me logo Genes that share pathways with SPRY1: view

Pathways by source for SPRY1 Gene

3 Reactome pathways for SPRY1 Gene
3 Cell Signaling Technology pathways for SPRY1 Gene

SIGNOR curated interactions for SPRY1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001759 organ induction IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SPRY1: view

Drugs & Compounds for SPRY1 Gene

No Compound Related Data Available

Transcripts for SPRY1 Gene

mRNA/cDNA for SPRY1 Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRY1

Clone Products

  • Addgene plasmids for SPRY1

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY1 Gene

No ASD Table

Relevant External Links for SPRY1 Gene

GeneLoc Exon Structure for
SPRY1

Expression for SPRY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.7) and Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for SPRY1 Gene

This gene is overexpressed in Breast (61.4) and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRY1 Gene



Protein tissue co-expression partners for SPRY1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRY1

SOURCE GeneReport for Unigene cluster for SPRY1 Gene:

Hs.744854

Evidence on tissue expression from TISSUES for SPRY1 Gene

  • Nervous system(4.5)
  • Heart(3.2)
  • Muscle(3.1)
  • Lung(2.7)
  • Kidney(2.7)
  • Thyroid gland(2.6)
  • Skin(2.6)
  • Intestine(2.6)
  • Adrenal gland(2.4)
  • Liver(2.3)
  • Eye(2.3)
  • Pancreas(2.3)
  • Blood(2.2)
  • Spleen(2.1)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SPRY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY1 Gene

Orthologs for SPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPRY1 30 31
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPRY1 30 31
  • 94.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPRY1 30 31
  • 93.42 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spry1 30 17 31
  • 82.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPRY1 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SPRY1 30
  • 80.29 (n)
Lizard
(Anolis carolinensis)
Reptilia SPRY1 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spry1 30
  • 75.39 (n)
Str.10330 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.10087 30
Zebrafish
(Danio rerio)
Actinopterygii spry1 30 31
  • 59.18 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta sty 31 32
  • 16 (a)
OneToMany
Species where no ortholog for SPRY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPRY1 Gene

ENSEMBL:
Gene Tree for SPRY1 (if available)
TreeFam:
Gene Tree for SPRY1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPRY1: view image

Paralogs for SPRY1 Gene

Paralogs for SPRY1 Gene

(3) SIMAP similar genes for SPRY1 Gene using alignment to 5 proteins:

  • SPY1_HUMAN
  • D6REX7_HUMAN
  • D6RHD2_HUMAN
  • D6RIE6_HUMAN
  • L8E896_HUMAN
genes like me logo Genes that share paralogs with SPRY1: view

Variants for SPRY1 Gene

Additional dbSNP identifiers (rs#s) for SPRY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPRY1 Gene

Variant ID Type Subtype PubMed ID
esv2759280 CNV gain 17122850
esv34581 CNV gain 17911159
esv3602044 CNV gain 21293372
nsv10562 CNV gain+loss 18304495

Variation tolerance for SPRY1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRY1 Gene

Human Gene Mutation Database (HGMD)
SPRY1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRY1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRY1 Gene

Disorders for SPRY1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SPRY1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SPRY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPRY1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SPRY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRY1 Gene

Publications for SPRY1 Gene

  1. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N … Krasnow MA (Cell 1998) 2 3 4
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41
  3. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PMID: 15962011) Haglund K … Dikic I (EMBO reports 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PMID: 14533010) Wang L … Mao Y (International journal of molecular medicine 2003) 3 4

Products for SPRY1 Gene

Sources for SPRY1 Gene