Aliases for SPRR2G Gene

Aliases for SPRR2G Gene

  • Small Proline Rich Protein 2G 2 3 5
  • Small Proline-Rich Protein 2G 2 3 4
  • SPR-2G 3 4
  • SPRR2G 5

External Ids for SPRR2G Gene

Previous GeneCards Identifiers for SPRR2G Gene

  • GC01U990161
  • GC01M151379
  • GC01M151390
  • GC01M153122
  • GC01M124485

Summaries for SPRR2G Gene

GeneCards Summary for SPRR2G Gene

SPRR2G (Small Proline Rich Protein 2G) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is SPRR1B.

UniProtKB/Swiss-Prot Summary for SPRR2G Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).

Additional gene information for SPRR2G Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRR2G Gene

Genomics for SPRR2G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPRR2G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153150 Promoter 0.3 EPDnew 600.3 +44.5 44467 0.1 lnc-SPRR2G-2 SPRR2G piR-31199-011 SPRR2F
GH01J153119 Promoter/Enhancer 1 EPDnew ENCODE 10.2 +75.8 75786 0.4 RFX1 LEF1 PKNOX1 SOX6 CTBP1 NCOR1 NR2F1 DPF2 ZEB2 MEIS2 SPRR2F SPRR2E SPRR2G SPRR2B piR-50968-009
GH01J153122 Enhancer 0.9 ENCODE 10.8 +71.8 71777 2.5 CREB1 PRDM10 ZHX2 FOXA1 LARP7 ZIC2 TCF12 IKZF2 POLR2A GTF2F1 piR-50968-009 SPRR2C SPRR2G LELP1 SPRR2B SPRR2F
GH01J153231 Enhancer 0.8 Ensembl ENCODE 9.3 -35.8 -35829 6.4 CTCF ZNF143 TRIM22 ESRRA NR2C1 NR2F1 NFIB ZNF654 HNF4A TBX21 PRR9 LORICRIN LELP1 SMCP SPRR2G RPLP0P4 lnc-LOR-4
GH01J153057 Promoter 0.4 EPDnew 9.7 +137.8 137845 0.1 SPI1 SPRR2A SPRR1B SPRR1A SPRR2G SPRR2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRR2G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRR2G

Top Transcription factor binding sites by QIAGEN in the SPRR2G gene promoter:
  • aMEF-2
  • ATF-2
  • C/EBPbeta
  • CUTL1
  • Evi-1
  • MEF-2A
  • MRF-2
  • Pbx1a
  • TBP

Genomic Locations for SPRR2G Gene

Genomic Locations for SPRR2G Gene
chr1:153,149,582-153,195,377
(GRCh38/hg38)
Size:
45,796 bases
Orientation:
Minus strand
chr1:153,122,058-153,123,427
(GRCh37/hg19)
Size:
1,370 bases
Orientation:
Minus strand

Genomic View for SPRR2G Gene

Genes around SPRR2G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRR2G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRR2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2G Gene

Proteins for SPRR2G Gene

  • Protein details for SPRR2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYE4-SPR2G_HUMAN
    Recommended name:
    Small proline-rich protein 2G
    Protein Accession:
    Q9BYE4

    Protein attributes for SPRR2G Gene

    Size:
    73 amino acids
    Molecular mass:
    8158 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2G Gene

Post-translational modifications for SPRR2G Gene

No Post-translational modifications

Other Protein References for SPRR2G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2G Gene

Domains & Families for SPRR2G Gene

Gene Families for SPRR2G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPRR2G Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRR2G Gene

GenScript: Design optimal peptide antigens:
  • Small proline-rich protein 2G (SPR2G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYE4

UniProtKB/Swiss-Prot:

SPR2G_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2G: view

Function for SPRR2G Gene

Molecular function for SPRR2G Gene

UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
UniProtKB/Swiss-Prot Induction:
During squamous differentiation of epidermal keratinocytes.
GENATLAS Biochemistry:
small proline rich protein 2G,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)

Phenotypes From GWAS Catalog for SPRR2G Gene

Phenotypes for SPRR2G Gene

genes like me logo Genes that share phenotypes with SPRR2G: view

Animal Model Products

CRISPR Products

miRNA for SPRR2G Gene

miRTarBase miRNAs that target SPRR2G

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRR2G

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRR2G Gene

Localization for SPRR2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2G Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRR2G gene
Compartment Confidence
plasma membrane 4
cytosol 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPRR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope NAS,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SPRR2G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPRR2G Gene

Pathways & Interactions for SPRR2G Gene

PathCards logo

SuperPathways for SPRR2G Gene

genes like me logo Genes that share pathways with SPRR2G: view

Pathways by source for SPRR2G Gene

Interacting Proteins for SPRR2G Gene

Gene Ontology (GO) - Biological Process for SPRR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with SPRR2G: view

No data available for SIGNOR curated interactions for SPRR2G Gene

Drugs & Compounds for SPRR2G Gene

No Compound Related Data Available

Transcripts for SPRR2G Gene

mRNA/cDNA for SPRR2G Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRR2G

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2G Gene

No ASD Table

Relevant External Links for SPRR2G Gene

GeneLoc Exon Structure for
SPRR2G

Expression for SPRR2G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRR2G Gene

mRNA differential expression in normal tissues according to GTEx for SPRR2G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x39.7) and Skin - Not Sun Exposed (Suprapubic) (x10.3).

Protein differential expression in normal tissues from HIPED for SPRR2G Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR2G Gene



Protein tissue co-expression partners for SPRR2G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRR2G

SOURCE GeneReport for Unigene cluster for SPRR2G Gene:

Hs.490253

Evidence on tissue expression from TISSUES for SPRR2G Gene

  • Skin(4.5)
genes like me logo Genes that share expression patterns with SPRR2G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRR2G Gene

Orthologs for SPRR2G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPRR2G 31
  • 99 (a)
OneToOne
Species where no ortholog for SPRR2G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPRR2G Gene

ENSEMBL:
Gene Tree for SPRR2G (if available)
TreeFam:
Gene Tree for SPRR2G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPRR2G: view image

Paralogs for SPRR2G Gene

genes like me logo Genes that share paralogs with SPRR2G: view

Variants for SPRR2G Gene

Additional dbSNP identifiers (rs#s) for SPRR2G Gene

Structural Variations from Database of Genomic Variants (DGV) for SPRR2G Gene

Variant ID Type Subtype PubMed ID
nsv1004168 CNV loss 25217958
nsv2921 CNV insertion 18451855
nsv547899 CNV gain 21841781

Variation tolerance for SPRR2G Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRR2G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRR2G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRR2G Gene

Disorders for SPRR2G Gene

No disorders were found for SPRR2G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2G Gene

Publications for SPRR2G Gene

  1. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A … Backendorf C (The Journal of biological chemistry 2001) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S … Backendorf C (Genomics 1993) 2 3
  4. Agrin has a pathological role in the progression of oral cancer. (PMID: 29872149) Rivera C … Paes Leme AF (British journal of cancer 2018) 3
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3

Products for SPRR2G Gene

Sources for SPRR2G Gene