Aliases for SPRR1B Gene
External Ids for SPRR1B Gene
Previous HGNC Symbols for SPRR1B Gene
Previous GeneCards Identifiers for SPRR1B Gene
The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
GeneCards Summary for SPRR1B Gene
SPRR1B (Small Proline Rich Protein 1B) is a Protein Coding gene. Diseases associated with SPRR1B include Cervical Intraepithelial Neoplasia and Epidermolytic Hyperkeratosis. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR1A.
UniProtKB/Swiss-Prot Summary for SPRR1B Gene
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.