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Aliases for SPRN Gene

Aliases for SPRN Gene

  • Shadow Of Prion Protein 2 3 5
  • Hypothetical Protein BC004409 2 3
  • Protein Shadoo 3 4
  • SHO 3 4
  • Shadow Of Prion Protein Homolog (Zebrafish) 2
  • Shadow Of Prion Protein Homolog 3
  • BA108K14.1 3
  • SHADOO 3

External Ids for SPRN Gene

Previous GeneCards Identifiers for SPRN Gene

  • GC10U900602
  • GC10M135085
  • GC10M135234
  • GC10M128777

Summaries for SPRN Gene

GeneCards Summary for SPRN Gene

SPRN (Shadow Of Prion Protein) is a Protein Coding gene. Diseases associated with SPRN include Prion Disease and Paranoid Personality Disorder. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SPRN Gene

  • Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Additional gene information for SPRN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRN Gene

Genomics for SPRN Gene

GeneHancer (GH) Regulatory Elements for SPRN Gene

Promoters and enhancers for SPRN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I133424 Promoter 0.6 EPDnew 550.8 0.0 -28 0.1 EZH2 SPRN OR6L2P
GH10I133425 Promoter 0.5 EPDnew 550.8 +0.3 287 0.1 SPRN MTG1
GH10I133393 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.3 +30.0 29962 2.4 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF213 MTG1 TUBGCP2 ENSG00000235245 SCART1 ZNF511 PAOX ENSG00000254536 SPRN
GH10I133400 Enhancer 0.4 ENCODE 0.3 +23.4 23443 1.5 JUNB BATF SCART1 MTG1 ENSG00000254536 SPRN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRN gene promoter:

Genomic Locations for SPRN Gene

Genomic Locations for SPRN Gene
3,952 bases
Minus strand

Genomic View for SPRN Gene

Genes around SPRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRN Gene

Proteins for SPRN Gene

  • Protein details for SPRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Shadow of prion protein
    Protein Accession:

    Protein attributes for SPRN Gene

    151 amino acids
    Molecular mass:
    14522 Da
    Quaternary structure:
    No Data Available
    • Shadoo means shadow in Japanese.

neXtProt entry for SPRN Gene

Post-translational modifications for SPRN Gene

Other Protein References for SPRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRN Gene

Domains & Families for SPRN Gene

Gene Families for SPRN Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Transporters

Protein Domains for SPRN Gene


Suggested Antigen Peptide Sequences for SPRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPRN family.
  • Belongs to the SPRN family.
genes like me logo Genes that share domains with SPRN: view

Function for SPRN Gene

Molecular function for SPRN Gene

UniProtKB/Swiss-Prot Function:
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Gene Ontology (GO) - Molecular Function for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SPRN: view
genes like me logo Genes that share phenotypes with SPRN: view

Animal Models for SPRN Gene

MGI Knock Outs for SPRN:

miRNA for SPRN Gene

miRTarBase miRNAs that target SPRN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRN Gene

Localization for SPRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRN Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRN gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SPRN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPRN Gene

Pathways & Interactions for SPRN Gene

genes like me logo Genes that share pathways with SPRN: view

Interacting Proteins for SPRN Gene

Selected Interacting proteins: Q5BIV9-SPRN_HUMAN for SPRN Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with SPRN: view

No data available for SIGNOR curated interactions for SPRN Gene

Drugs & Compounds for SPRN Gene

No Compound Related Data Available

Transcripts for SPRN Gene

mRNA/cDNA for SPRN Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRN Gene

Shadow of prion protein homolog (zebrafish):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRN Gene

No ASD Table

Relevant External Links for SPRN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRN Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRN Gene

NURSA nuclear receptor signaling pathways regulating expression of SPRN Gene:


SOURCE GeneReport for Unigene cluster for SPRN Gene:


mRNA Expression by UniProt/SwissProt for SPRN Gene:

Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus.

Evidence on tissue expression from TISSUES for SPRN Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SPRN: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRN Gene

Orthologs for SPRN Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRN 34 33
  • 98.9 (n)
(Canis familiaris)
Mammalia SPRN 34
  • 83 (a)
LOC100855950 33
  • 82.17 (n)
(Mus musculus)
Mammalia Sprn 33 16 34
  • 76.42 (n)
(Rattus norvegicus)
Mammalia Sprn 33
  • 75.06 (n)
(Bos Taurus)
Mammalia SPRN 33 34
  • 74.13 (n)
Species where no ortholog for SPRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRN Gene

Gene Tree for SPRN (if available)
Gene Tree for SPRN (if available)

Paralogs for SPRN Gene

No data available for Paralogs for SPRN Gene

Variants for SPRN Gene

Sequence variations from dbSNP and Humsavar for SPRN Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000959523 -- 133,422,970(-) T/C 3_prime_UTR_variant
rs1001560331 -- 133,422,150(-) G/A 3_prime_UTR_variant
rs1003431369 -- 133,422,215(-) C/T 3_prime_UTR_variant
rs1004163514 -- 133,425,449(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRN Gene

Variant ID Type Subtype PubMed ID
dgv1000n100 CNV gain 25217958
dgv1001n100 CNV gain 25217958
dgv123n27 CNV gain 19166990
dgv124n27 CNV gain 19166990
dgv125n27 CNV gain 19166990
dgv1486n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv1488n54 CNV gain 21841781
dgv1489n54 CNV gain 21841781
dgv2e196 CNV duplication 17116639
dgv304e212 CNV gain 25503493
dgv35e55 CNV gain 17911159
dgv39n111 CNV duplication 26073780
dgv3e196 CNV duplication 17116639
dgv999n100 CNV gain 25217958
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760130 CNV gain+loss 21179565
esv2764146 CNV gain+loss 21179565
esv28562 CNV gain+loss 19812545
esv33719 CNV gain 17666407
esv3579239 CNV loss 25503493
nsv1043323 CNV gain 25217958
nsv1052033 CNV gain 25217958
nsv1052904 CNV gain 25217958
nsv428243 CNV gain 18775914
nsv469597 CNV gain 16826518
nsv470981 CNV gain 18288195
nsv514545 CNV gain 21397061
nsv517180 CNV gain+loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv7631 CNV deletion 18451855
nsv832041 CNV gain 17160897
nsv952708 CNV deletion 24416366

Variation tolerance for SPRN Gene

Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRN Gene

Disorders for SPRN Gene

MalaCards: The human disease database

(6) MalaCards diseases for SPRN Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
prion disease
  • prion disease pathway
paranoid personality disorder
avoidant personality disorder
  • anxious personality disorder
creutzfeldt-jakob disease
  • cjd
- elite association - COSMIC cancer census association via MalaCards
Search SPRN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPRN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRN Gene

Publications for SPRN Gene

  1. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PMID: 14527721) Premzl M … Gready JE (Gene 2003) 2 3 4 22 58
  2. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PMID: 18805828) Beck JA … Mead S (Journal of medical genetics 2008) 3 22 44 58
  3. Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis. (PMID: 15342797) Premzl M … Marshall Graves JA (Molecular biology and evolution 2004) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SPRN Gene

Sources for SPRN Gene

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