Aliases for SPRED3 Gene
External Ids for SPRED3 Gene
Previous GeneCards Identifiers for SPRED3 Gene
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SPRED3 Gene
SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Optic Atrophy 2 and Legius Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is SPRED2.
UniProtKB/Swiss-Prot Summary for SPRED3 Gene
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).