This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in m... See more...

Aliases for SPRED3 Gene

Aliases for SPRED3 Gene

  • Sprouty Related EVH1 Domain Containing 3 2 3 5
  • Sprouty-Related, EVH1 Domain-Containing Protein 3 3 4
  • Spred-3 3 4
  • SPRED3 5
  • Eve-3 3
  • EVE-3 4

External Ids for SPRED3 Gene

Previous GeneCards Identifiers for SPRED3 Gene

  • GC19U900378
  • GC19P043574
  • GC19P038880
  • GC19P035328

Summaries for SPRED3 Gene

Entrez Gene Summary for SPRED3 Gene

  • This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SPRED3 Gene

SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Optic Atrophy 2 and Legius Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is SPRED2.

UniProtKB/Swiss-Prot Summary for SPRED3 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Gene Wiki entry for SPRED3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRED3 Gene

Genomics for SPRED3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPRED3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRED3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRED3

Top Transcription factor binding sites by QIAGEN in the SPRED3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1
  • Nkx2-5
  • NRF-2
  • Zic3

Genomic Locations for SPRED3 Gene

Latest Assembly
chr19:38,388,421-38,399,884
(GRCh38/hg38)
Size:
11,464 bases
Orientation:
Plus strand

Previous Assembly
chr19:38,880,840-38,890,524
(GRCh37/hg19 by Entrez Gene)
Size:
9,685 bases
Orientation:
Plus strand

chr19:38,879,061-38,886,881
(GRCh37/hg19 by Ensembl)
Size:
7,821 bases
Orientation:
Plus strand

Genomic View for SPRED3 Gene

Genes around SPRED3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED3 Gene

Proteins for SPRED3 Gene

  • Protein details for SPRED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2MJR0-SPRE3_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Protein Accession:
    Q2MJR0
    Secondary Accessions:
    • Q2MJR1

    Protein attributes for SPRED3 Gene

    Size:
    410 amino acids
    Molecular mass:
    42670 Da
    Quaternary structure:
    • Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED3.

    Alternative splice isoforms for SPRED3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPRED3 Gene

Post-translational modifications for SPRED3 Gene

Other Protein References for SPRED3 Gene

No data available for DME Specific Peptides for SPRED3 Gene

Domains & Families for SPRED3 Gene

Gene Families for SPRED3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRED3 Gene

InterPro:
Blocks:
  • Sprouty

Suggested Antigen Peptide Sequences for SPRED3 Gene

GenScript: Design optimal peptide antigens:
  • Sprouty-related, EVH1 domain containing 3 (B9EKV1_HUMAN)
  • Sprouty-related, EVH1 domain-containing protein 3 (SPRE3_HUMAN)
genes like me logo Genes that share domains with SPRED3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPRED3 Gene

Function for SPRED3 Gene

Molecular function for SPRED3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SPRED3 Gene

Gene Ontology (GO) - Molecular Function for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with SPRED3: view
genes like me logo Genes that share phenotypes with SPRED3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRED3 Gene

Localization for SPRED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED3 Gene

Cell membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 0
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRED3: view

Pathways & Interactions for SPRED3 Gene

PathCards logo

SuperPathways for SPRED3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by PTK6
genes like me logo Genes that share pathways with SPRED3: view

Pathways by source for SPRED3 Gene

Gene Ontology (GO) - Biological Process for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0009966 regulation of signal transduction IEA --
GO:0010719 negative regulation of epithelial to mesenchymal transition ISS --
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with SPRED3: view

No data available for SIGNOR curated interactions for SPRED3 Gene

Drugs & Compounds for SPRED3 Gene

No Compound Related Data Available

Transcripts for SPRED3 Gene

mRNA/cDNA for SPRED3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED3

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED3 Gene

No ASD Table

Relevant External Links for SPRED3 Gene

GeneLoc Exon Structure for
SPRED3

Expression for SPRED3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRED3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRED3 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRED3 Gene



Protein tissue co-expression partners for SPRED3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRED3

SOURCE GeneReport for Unigene cluster for SPRED3 Gene:

Hs.196011

Evidence on tissue expression from TISSUES for SPRED3 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with SPRED3: view

Primer products for research

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED3 Gene

Orthologs for SPRED3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPRED3 29 30
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPRED3 29 30
  • 92.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPRED3 29 30
  • 91.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spred3 29 16 30
  • 87.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spred3 29
  • 83.02 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 30 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia SPRED3 30
  • 41 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Spred 30
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10713 30
  • 22 (a)
OneToMany
Species where no ortholog for SPRED3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPRED3 Gene

ENSEMBL:
Gene Tree for SPRED3 (if available)
TreeFam:
Gene Tree for SPRED3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPRED3: view image
Alliance of Genome Resources:
Additional Orthologs for SPRED3

Paralogs for SPRED3 Gene

Paralogs for SPRED3 Gene

(3) SIMAP similar genes for SPRED3 Gene using alignment to 5 proteins:

  • SPRE3_HUMAN
  • B9EKV1_HUMAN
  • K7EKP4_HUMAN
  • K7EPT9_HUMAN
  • K7EPU5_HUMAN
genes like me logo Genes that share paralogs with SPRED3: view

Variants for SPRED3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRED3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs370701407 Benign: not provided 38,390,455(+) C/T
NM_001042522.2(SPRED3):c.153C>T (p.His51=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPRED3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPRED3 Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for SPRED3 Gene

Gene Damage Index Score: 2.68; 46.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRED3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRED3
Leiden Open Variation Database (LOVD)
SPRED3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED3 Gene

Disorders for SPRED3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SPRED3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
optic atrophy 2
  • opa2
legius syndrome
  • lgss
leopard syndrome 1
  • lprd1
cardiofaciocutaneous syndrome 1
  • cfc1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPRED3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SPRED3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED3 Gene

Publications for SPRED3 Gene

  1. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 4
  2. Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. (PMID: 17094949) Lock P … Stylli SS (Biochemical and biophysical research communications 2006) 3 4
  3. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PMID: 16478641) King JA … Hovens CM (Journal of hepatology 2006) 3 4
  4. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y … Katoh M (International journal of molecular medicine 2006) 3 22
  5. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PMID: 14618415) Mizoguchi M … Louis DN (Neurogenetics 2004) 2 3

Products for SPRED3 Gene

Sources for SPRED3 Gene