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SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008] See more...
Aliases for SPRED2 Gene
Aliases for SPRED2 Gene
External Ids for SPRED2 Gene
- HGNC: 17722
- Entrez Gene: 200734
- Ensembl: ENSG00000198369
- OMIM: 609292
- UniProtKB: Q7Z698
Previous GeneCards Identifiers for SPRED2 Gene
- GC02M065495
- GC02M065512
- GC02M065449
- GC02M065537
- GC02M065272
Summaries for SPRED2 Gene
-
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SPRED2 Gene
SPRED2 (Sprouty Related EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include Legius Syndrome and Cardiofaciocutaneous Syndrome 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and stem cell factor receptor binding. An important paralog of this gene is SPRED1.
UniProtKB/Swiss-Prot Summary for SPRED2 Gene
-
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Additional gene information for SPRED2 Gene
- HGNC(17722)
- Entrez Gene(200734)
- Ensembl(ENSG00000198369)
- OMIM(609292)
- UniProtKB(Q7Z698)
- Open Targets Platform(ENSG00000198369)
- Monarch Initiative
- Search for SPRED2 at DataMed
- Search for SPRED2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRED2 Gene
Genomics for SPRED2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SPRED2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPRED2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRED2
- Top Transcription factor binding sites by QIAGEN in the SPRED2 gene promoter:
-
- Bach1
- FOXF2
- FOXL1
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- Pax-5
- SRY
Genomic Locations for SPRED2 Gene
Genomic Locations for SPRED2 Gene
- chr2:65,307,425-65,432,637
- (GRCh38/hg38)
- Size:
- 125,213 bases
- Orientation:
- Minus strand
- chr2:65,537,985-65,659,771
- (GRCh37/hg19)
- Size:
- 121,787 bases
- Orientation:
- Minus strand
Genomic View for SPRED2 Gene
Genes around SPRED2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by HGNC
- 2p14 by Entrez Gene
- 2p14 by Ensembl
SPRED2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPRED2 Gene
Proteins for SPRED2 Gene
-
Protein details for SPRED2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z698-SPRE2_HUMAN
- Recommended name:
- Sprouty-related, EVH1 domain-containing protein 2
- Protein Accession:
- Q7Z698
- A1L3V4
- B7Z5K7
- D6W5F7
- E9PEP0
- Q2NKX6
Protein attributes for SPRED2 Gene
- Size:
- 418 amino acids
- Molecular mass:
- 47558 Da
- Quaternary structure:
-
- Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED1 to form heterodimers (PubMed:15683364). Interacts with RAS (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity).
Protein Expression for SPRED2 Gene
Post-translational modifications for SPRED2 Gene
- Phosphorylated on serine and threonine residues (PubMed:15683364). Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination (PubMed:17094949).
- Ubiquitinated; leading to degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SPRED2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPRED2
-
Abcam antibodies for SPRED2
- Invitrogen Antibodies for SPRED2 (AFLGC-Spred2)
-
Boster Bio Antibodies for SPRED2
-
Custom Antibody ServicesProSci Antibodies for SPRED2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPRED2
Protein Products
-
OriGene Purified Proteins for SPRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRED2
- Origene Custom Protein Services for SPRED2
- antibodies-online: Show 6 available SPRED2 Proteins ranked by validation data
- Compare Top SPRED2 Proteins
-
Quality Products:
-
Abcam proteins for SPRED2
No data available for DME Specific Peptides for SPRED2 Gene
Domains & Families for SPRED2 Gene
Gene Families for SPRED2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for SPRED2 Gene
- InterPro:
- Blocks:
-
- Sprouty
- ProtoNet:
Suggested Antigen Peptide Sequences for SPRED2 Gene
- GenScript: Design optimal peptide antigens:
-
- Sprouty-related, EVH1 domain-containing protein 2 (SPRE2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPRED2 Gene
Function for SPRED2 Gene
Molecular function for SPRED2 Gene
- UniProtKB/Swiss-Prot Function:
- Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Phenotypes From GWAS Catalog for SPRED2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005173 | stem cell factor receptor binding | ISS | -- |
| GO:0005515 | protein binding | IPI | 19822672 |
| GO:0019901 | protein kinase binding | IPI | 20736167 |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | ISS | 20736167 |
Phenotypes for SPRED2 Gene
- MGI mutant phenotypes for SPRED2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SPRED2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased viability with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs
- Increased cell migration
Animal Models for SPRED2 Gene
- MGI Knock Outs for SPRED2:
-
- Spred2 Spred2<tm1Taga>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPRED2 - Select products 50% OFF >
- * SPRED2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRED2
miRNA for SPRED2 Gene
- miRTarBase miRNAs that target SPRED2
-
- mmu-miR-324-3p (MIRT010860)
- hsa-miR-186-5p (MIRT021167)
- hsa-miR-6822-5p (MIRT569480)
- hsa-miR-6842-3p (MIRT569481)
- hsa-miR-647 (MIRT569482)
- hsa-miR-215-5p (MIRT569483)
- hsa-miR-192-5p (MIRT569484)
- hsa-miR-4715-5p (MIRT569485)
- hsa-miR-1914-5p (MIRT569486)
- hsa-miR-6776-3p (MIRT569487)
- hsa-miR-31-5p (MIRT734194)
- hsa-miR-487a-3p (MIRT734706)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRED2
- Browse OriGene Inhibitory RNA Products For SPRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED2
Clone Products
- Applied Biological Materials (abm): Clones for SPRED2 - Select products 50% OFF >
- * SPRED2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPRED2
- Addgene plasmids for SPRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRED2
Cell Line Products
-
Horizon Cell Lines for SPRED2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRED2 Gene
Localization for SPRED2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPRED2 Gene
- Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269 PubMed:15580519}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030658 | transport vesicle membrane | IEA | -- |
Pathways & Interactions for SPRED2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Developmental Biology |
.51
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Negative regulation of FGFR3 signaling | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for SPRED2 Gene
1 Sino Biological pathway for SPRED2 Gene
1 BioSystems pathway for SPRED2 Gene
52 Reactome pathways for SPRED2 Gene
Interacting Proteins for SPRED2 Gene
Selected Interacting proteins:
Q7Z698-SPRE2_HUMAN
ENSP00000348753
for SPRED2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SPRED2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IBA,ISS | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
| GO:0009966 | regulation of signal transduction | IEA | -- |
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | ISS | -- |
No data available for SIGNOR curated interactions for SPRED2 Gene
Transcripts for SPRED2 Gene
mRNA/cDNA for SPRED2 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356388 4519 nts (view in UCSC)
- ENST00000421087 701 nts (view in UCSC)
- ENST00000426832 498 nts (view in UCSC)
- ENST00000427238 467 nts (view in UCSC)
- ENST00000440972 555 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPRED2 - Select products 50% OFF >
- * SPRED2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRED2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRED2
- Browse OriGene Inhibitory RNA Products For SPRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED2
Clone Products
- Applied Biological Materials (abm): Clones for SPRED2 - Select products 50% OFF >
- * SPRED2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPRED2
- Addgene plasmids for SPRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRED2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | |||||||||||||||
| SP3: | - | - | |||||||||||||
| SP4: | - | - |
Relevant External Links for SPRED2 Gene
- GeneLoc Exon Structure for
- SPRED2
Expression for SPRED2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Pancreas (68.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPRED2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRED2
SOURCE GeneReport for Unigene cluster for SPRED2 Gene:
Hs.59332mRNA Expression by UniProt/SwissProt for SPRED2 Gene:
Q7Z698-SPRE2_HUMAN
Tissue specificity:
Expressed in liver, skin, small intestine, salivary gland and prostate.
Evidence on tissue expression from TISSUES for SPRED2 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for SPRED2
-
OriGene qPCR primer pairs and template standards for SPRED2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED2 Gene
Orthologs for SPRED2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SPRED2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SPRED2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SPRED2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SPRED2 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Spred2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Spred2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SPRED2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SPRED2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SPRED2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spred2 30 |
|
||
| Str.15856 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | spred2b 30 31 |
|
OneToMany | |
| spred2a 31 |
|
OneToMany | |||
| wufb93f08 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Spred 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012085 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10713 31 |
|
OneToMany |
- Species where no ortholog for SPRED2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SPRED2 Gene
- ENSEMBL:
- Gene Tree for SPRED2 (if available)
- TreeFam:
- Gene Tree for SPRED2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPRED2: view image
Paralogs for SPRED2 Gene
Variants for SPRED2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRED2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 775723 | Benign: not provided | 65,344,842(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2045738 | CNV | deletion | 18987734 |
| esv2720153 | CNV | deletion | 23290073 |
| esv2720154 | CNV | deletion | 23290073 |
| esv2720155 | CNV | deletion | 23290073 |
| esv2720156 | CNV | deletion | 23290073 |
| esv2720157 | CNV | deletion | 23290073 |
| esv2720158 | CNV | deletion | 23290073 |
| nsv1114093 | CNV | deletion | 24896259 |
| nsv213210 | CNV | deletion | 16902084 |
| nsv2758 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPRED2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED2 Gene
Disorders for SPRED2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| legius syndrome |
|
|
| cardiofaciocutaneous syndrome 1 |
|
|
Search SPRED2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPRED2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED2 Gene
Publications for SPRED2 Gene
- Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. (PMID: 17094949) Lock P … Stylli SS (Biochemical and biophysical research communications 2006) 3 4 23
- Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PMID: 21383967) Zhernakova A … Plenge RM (PLoS genetics 2011) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 41
ExternalLinks
Products for SPRED2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SPRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRED2
- Origene Custom Protein Services for SPRED2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPRED2
- Browse OriGene Inhibitory RNA Products For SPRED2
- OriGene qPCR primer pairs for SPRED2
- OriGene qPCR primer pairs and template standards for SPRED2
- OriGene CRISPR knockouts for SPRED2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPRED2
- Sino Biological Human cDNA Clone for SPRED2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPRED2
- Novus Biologicals proteins and lysates for SPRED2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SPRED2
- Abcam proteins for SPRED2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SPRED2 (AFLGC-Spred2)
- VectorBuilder Custom and pre-made DNA vectors for SPRED2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SPRED2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SPRED2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SPRED2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SPRED2
- Addgene plasmids for SPRED2
- antibodies-online: Show 4 available SPRED2 Antibodies ranked by validation data
- Compare Top SPRED2 Antibodies
- antibodies-online: Search results for available SPRED2 related products ranked by validation data
- antibodies-online: Show 6 available SPRED2 Proteins ranked by validation data
- Compare Top SPRED2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SPRED2
- Search Santa Cruz Biotechnology (SCBT) for SPRED2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPRED2
- Custom Antibody ServicesProSci Antibodies for SPRED2
- Search for SPRED2 Proteins at ProSci
- Horizon Cell Lines for SPRED2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPRED2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SPRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED2
- Boster Bio Antibodies for SPRED2
- Browse Boster Bio ELISA Kits
Sources for SPRED2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
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