Aliases for SPRED2 Gene
External Ids for SPRED2 Gene
Previous GeneCards Identifiers for SPRED2 Gene
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SPRED2 Gene
SPRED2 (Sprouty Related EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include Legius Syndrome and Cardiofaciocutaneous Syndrome 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and stem cell factor receptor binding. An important paralog of this gene is SPRED1.
UniProtKB/Swiss-Prot Summary for SPRED2 Gene
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).