SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008] See more...

Aliases for SPRED2 Gene

Aliases for SPRED2 Gene

  • Sprouty Related EVH1 Domain Containing 2 2 3 5
  • Spred-2 2 3 4
  • Sprouty-Related, EVH1 Domain-Containing Protein 2 3 4
  • Sprouty Protein With EVH-1 Domain 2, Related Sequence 3
  • FLJ21897 2
  • FLJ31917 2
  • SPRED2 5

External Ids for SPRED2 Gene

Previous GeneCards Identifiers for SPRED2 Gene

  • GC02M065495
  • GC02M065512
  • GC02M065449
  • GC02M065537
  • GC02M065272

Summaries for SPRED2 Gene

Entrez Gene Summary for SPRED2 Gene

  • SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SPRED2 Gene

SPRED2 (Sprouty Related EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include Legius Syndrome and Cardiofaciocutaneous Syndrome 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and stem cell factor receptor binding. An important paralog of this gene is SPRED1.

UniProtKB/Swiss-Prot Summary for SPRED2 Gene

  • Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Gene Wiki entry for SPRED2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRED2 Gene

Genomics for SPRED2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPRED2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRED2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRED2

Top Transcription factor binding sites by QIAGEN in the SPRED2 gene promoter:
  • Bach1
  • FOXF2
  • FOXL1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-5
  • SRY

Genomic Locations for SPRED2 Gene

Genomic Locations for SPRED2 Gene
chr2:65,307,425-65,432,637
(GRCh38/hg38)
Size:
125,213 bases
Orientation:
Minus strand
chr2:65,537,985-65,659,771
(GRCh37/hg19)
Size:
121,787 bases
Orientation:
Minus strand

Genomic View for SPRED2 Gene

Genes around SPRED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED2 Gene

Proteins for SPRED2 Gene

  • Protein details for SPRED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z698-SPRE2_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 2
    Protein Accession:
    Q7Z698
    Secondary Accessions:
    • A1L3V4
    • B7Z5K7
    • D6W5F7
    • E9PEP0
    • Q2NKX6

    Protein attributes for SPRED2 Gene

    Size:
    418 amino acids
    Molecular mass:
    47558 Da
    Quaternary structure:
    • Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED1 to form heterodimers (PubMed:15683364). Interacts with RAS (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity).

    Three dimensional structures from OCA and Proteopedia for SPRED2 Gene

    Alternative splice isoforms for SPRED2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPRED2 Gene

Post-translational modifications for SPRED2 Gene

  • Phosphorylated on serine and threonine residues (PubMed:15683364). Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination (PubMed:17094949).
  • Ubiquitinated; leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPRED2 Gene

Domains & Families for SPRED2 Gene

Gene Families for SPRED2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRED2 Gene

InterPro:
Blocks:
  • Sprouty
ProtoNet:

Suggested Antigen Peptide Sequences for SPRED2 Gene

GenScript: Design optimal peptide antigens:
  • Sprouty-related, EVH1 domain-containing protein 2 (SPRE2_HUMAN)
genes like me logo Genes that share domains with SPRED2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPRED2 Gene

Function for SPRED2 Gene

Molecular function for SPRED2 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SPRED2 Gene

Gene Ontology (GO) - Molecular Function for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding ISS --
GO:0005515 protein binding IPI 19822672
GO:0019901 protein kinase binding IPI 20736167
GO:0030291 protein serine/threonine kinase inhibitor activity ISS 20736167
genes like me logo Genes that share ontologies with SPRED2: view
genes like me logo Genes that share phenotypes with SPRED2: view

Animal Models for SPRED2 Gene

MGI Knock Outs for SPRED2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRED2 Gene

Localization for SPRED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED2 Gene

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269 PubMed:15580519}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030658 transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with SPRED2: view

Pathways & Interactions for SPRED2 Gene

PathCards logo

SuperPathways for SPRED2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Negative regulation of FGFR3 signaling
5 Innate Immune System
genes like me logo Genes that share pathways with SPRED2: view

Pathways by source for SPRED2 Gene

1 Sino Biological pathway for SPRED2 Gene

Gene Ontology (GO) - Biological Process for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IBA,ISS --
GO:0007275 multicellular organism development IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009966 regulation of signal transduction IEA --
GO:0010719 negative regulation of epithelial to mesenchymal transition ISS --
genes like me logo Genes that share ontologies with SPRED2: view

No data available for SIGNOR curated interactions for SPRED2 Gene

Drugs & Compounds for SPRED2 Gene

No Compound Related Data Available

Transcripts for SPRED2 Gene

mRNA/cDNA for SPRED2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED2

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -
SP4: - -

Relevant External Links for SPRED2 Gene

GeneLoc Exon Structure for
SPRED2

Expression for SPRED2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRED2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRED2 Gene

This gene is overexpressed in Pancreas (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPRED2 Gene



Protein tissue co-expression partners for SPRED2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRED2

SOURCE GeneReport for Unigene cluster for SPRED2 Gene:

Hs.59332

mRNA Expression by UniProt/SwissProt for SPRED2 Gene:

Q7Z698-SPRE2_HUMAN
Tissue specificity: Expressed in liver, skin, small intestine, salivary gland and prostate.

Evidence on tissue expression from TISSUES for SPRED2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with SPRED2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED2 Gene

Orthologs for SPRED2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPRED2 30 31
  • 98.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPRED2 30 31
  • 94.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPRED2 30 31
  • 92.86 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPRED2 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spred2 30
  • 88.78 (n)
Mouse
(Mus musculus)
Mammalia Spred2 30 17 31
  • 88.21 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SPRED2 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SPRED2 30 31
  • 76.6 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPRED2 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spred2 30
  • 71.56 (n)
Str.15856 30
Zebrafish
(Danio rerio)
Actinopterygii spred2b 30 31
  • 70.53 (n)
OneToMany
spred2a 31
  • 67 (a)
OneToMany
wufb93f08 30
Fruit Fly
(Drosophila melanogaster)
Insecta Spred 30 31
  • 49.39 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012085 30
  • 35.78 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10713 31
  • 24 (a)
OneToMany
Species where no ortholog for SPRED2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPRED2 Gene

ENSEMBL:
Gene Tree for SPRED2 (if available)
TreeFam:
Gene Tree for SPRED2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPRED2: view image

Paralogs for SPRED2 Gene

Paralogs for SPRED2 Gene

(3) SIMAP similar genes for SPRED2 Gene using alignment to 6 proteins:

  • SPRE2_HUMAN
  • C9J623_HUMAN
  • C9JG63_HUMAN
  • H7C065_HUMAN
  • H7C2T4_HUMAN
  • H7C3Y6_HUMAN
genes like me logo Genes that share paralogs with SPRED2: view

Variants for SPRED2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRED2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
775723 Benign: not provided 65,344,842(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SPRED2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPRED2 Gene

Variant ID Type Subtype PubMed ID
esv2045738 CNV deletion 18987734
esv2720153 CNV deletion 23290073
esv2720154 CNV deletion 23290073
esv2720155 CNV deletion 23290073
esv2720156 CNV deletion 23290073
esv2720157 CNV deletion 23290073
esv2720158 CNV deletion 23290073
nsv1114093 CNV deletion 24896259
nsv213210 CNV deletion 16902084
nsv2758 CNV insertion 18451855

Variation tolerance for SPRED2 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRED2 Gene

Human Gene Mutation Database (HGMD)
SPRED2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED2 Gene

Disorders for SPRED2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPRED2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • lgss
cardiofaciocutaneous syndrome 1
  • cfc1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPRED2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SPRED2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED2 Gene

Publications for SPRED2 Gene

  1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. (PMID: 17094949) Lock P … Stylli SS (Biochemical and biophysical research communications 2006) 3 4 23
  2. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PMID: 21383967) Zhernakova A … Plenge RM (PLoS genetics 2011) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41
  5. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 41

Products for SPRED2 Gene

Sources for SPRED2 Gene