The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by ... See more...

Aliases for SPRED1 Gene

Aliases for SPRED1 Gene

  • Sprouty Related EVH1 Domain Containing 1 2 3 5
  • Sprouty-Related, EVH1 Domain-Containing Protein 1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 147 2 3
  • PPP1R147 2 3
  • HSpred1 3 4
  • Spred-1 3 4
  • Suppressor Of Ras/MAPK Activation 3
  • FLJ33903 2
  • SPRED1 5
  • LGSS 3
  • NFLS 3

External Ids for SPRED1 Gene

Previous GeneCards Identifiers for SPRED1 Gene

  • GC15P031440
  • GC15P036123
  • GC15P036260
  • GC15P036331
  • GC15P038545
  • GC15P015389

Summaries for SPRED1 Gene

Entrez Gene Summary for SPRED1 Gene

  • The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

GeneCards Summary for SPRED1 Gene

SPRED1 (Sprouty Related EVH1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SPRED1 include Legius Syndrome and Neurofibromatosis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRED2.

UniProtKB/Swiss-Prot Summary for SPRED1 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Gene Wiki entry for SPRED1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPRED1 Gene

Genomics for SPRED1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPRED1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J038250 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255 +2.3 2314 8.4 ZNF654 NCOR1 MYC IKZF1 ZNF600 JUND ZNF580 ATF2 CEBPA ZNF10 SPRED1 ENSG00000259380 LOC107984760 HSALNG0105111 piR-50437-205 FAM98B
GH15J038071 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -179.2 -179229 3.1 ZNF600 SSRP1 ATF2 KLF9 ZNF10 NFIC POLR2A ZIC2 MXD4 CTCF HSALNG0105101 LINC01852 lnc-TMCO5A-7 SPRED1 FAM98B TMCO5A
GH15J038068 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -182.9 -182923 2.3 BCLAF1 SP1 BCL11A ZNF217 ELF1 IRF4 EBF1 CBFB BHLHE40 BATF SPRED1 HSALNG0105101 LINC01852 LOC107984774 TMCO5A
GH15J038079 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -168.8 -168786 9.8 BCLAF1 SP1 ZNF207 BCL11A TARDBP TRIM22 FEZF1 ZNF513 IRF4 ZNF316 SPRED1 LINC01852 hsa-miR-5095-153 HSALNG0105103 TMCO5A
GH15J038126 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 10.4 -122.4 -122426 5.3 NCOR1 JUND BCL11A CEBPB HES1 EP300 GABPA TAL1 STAT3 NFE2 SPRED1 piR-61580-212 HSALNG0105103 TMCO5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPRED1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPRED1

Top Transcription factor binding sites by QIAGEN in the SPRED1 gene promoter:
  • aMEF-2
  • AML1a
  • FOXF2
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • TBP

Genomic Locations for SPRED1 Gene

Latest Assembly
chr15:38,252,087-38,357,249
(GRCh38/hg38)
Size:
105,163 bases
Orientation:
Plus strand

Previous Assembly
chr15:38,545,037-38,649,450
(GRCh37/hg19 by Entrez Gene)
Size:
104,414 bases
Orientation:
Plus strand

chr15:38,544,527-38,649,450
(GRCh37/hg19 by Ensembl)
Size:
104,924 bases
Orientation:
Plus strand

Genomic View for SPRED1 Gene

Genes around SPRED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED1 Gene

Proteins for SPRED1 Gene

  • Protein details for SPRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z699-SPRE1_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 1
    Protein Accession:
    Q7Z699
    Secondary Accessions:
    • B2RPJ8
    • Q05D53
    • Q8N256

    Protein attributes for SPRED1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50477 Da
    Quaternary structure:
    • Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED2 to form heterodimers (PubMed:15683364). Interacts (via C-terminus) with TAOK1/MARKK (via C-terminus); the interaction does not affect TAOK1 kinase activity (PubMed:18216281). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:18216281). Interacts with CAV1 (PubMed:16115197). Interacts with RAS (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED1 (PubMed:24705354).
    SequenceCaution:
    • Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPRED1 Gene

neXtProt entry for SPRED1 Gene

Post-translational modifications for SPRED1 Gene

Other Protein References for SPRED1 Gene

No data available for DME Specific Peptides for SPRED1 Gene

Domains & Families for SPRED1 Gene

Gene Families for SPRED1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRED1 Gene

InterPro:
Blocks:
  • Sprouty

Suggested Antigen Peptide Sequences for SPRED1 Gene

GenScript: Design optimal peptide antigens:
  • Sprouty-related, EVH1 domain-containing protein 1 (SPRE1_HUMAN)
genes like me logo Genes that share domains with SPRED1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPRED1 Gene

Function for SPRED1 Gene

Molecular function for SPRED1 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SPRED1 Gene

Gene Ontology (GO) - Molecular Function for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding IEA,ISS --
GO:0005515 protein binding IPI 15231748
GO:0019901 protein kinase binding IEA,IPI 18216281
GO:0019902 phosphatase binding IDA 19389623
GO:0030291 protein serine/threonine kinase inhibitor activity IEA,ISS 20736167
genes like me logo Genes that share ontologies with SPRED1: view
genes like me logo Genes that share phenotypes with SPRED1: view

Human Phenotype Ontology for SPRED1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPRED1 Gene

MGI Knock Outs for SPRED1:

miRNA for SPRED1 Gene

miRTarBase miRNAs that target SPRED1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPRED1 Gene

Localization for SPRED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED1 Gene

Cell membrane. Peripheral membrane protein. Membrane, caveola. Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SPRED1: view

Pathways & Interactions for SPRED1 Gene

PathCards logo

SuperPathways for SPRED1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Negative regulation of FGFR3 signaling
5 Innate Immune System
genes like me logo Genes that share pathways with SPRED1: view

Pathways by source for SPRED1 Gene

Gene Ontology (GO) - Biological Process for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000188 inactivation of MAPK activity IEA,ISS --
GO:0006469 negative regulation of protein kinase activity IDA 18216281
GO:0007275 multicellular organism development IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SPRED1: view

No data available for SIGNOR curated interactions for SPRED1 Gene

Drugs & Compounds for SPRED1 Gene

No Compound Related Data Available

Transcripts for SPRED1 Gene

mRNA/cDNA for SPRED1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPRED1

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED1 Gene

No ASD Table

Relevant External Links for SPRED1 Gene

GeneLoc Exon Structure for
SPRED1

Expression for SPRED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRED1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRED1 Gene



Protein tissue co-expression partners for SPRED1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPRED1

SOURCE GeneReport for Unigene cluster for SPRED1 Gene:

Hs.525781

mRNA Expression by UniProt/SwissProt for SPRED1 Gene:

Q7Z699-SPRE1_HUMAN
Tissue specificity: Weakly expressed in embryonic cell line HEK293.

Evidence on tissue expression from TISSUES for SPRED1 Gene

  • Nervous system(4.7)
  • Heart(2.6)
  • Muscle(2.1)
  • Kidney(2.1)
  • Lung(2.1)
  • Spleen(2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • outer ear
  • scalp
  • skull
Limb:
  • arm
  • upper limb
General:
  • hair
  • skin
  • spinal column
genes like me logo Genes that share expression patterns with SPRED1: view

Primer products for research

No data available for mRNA differential expression in normal tissues for SPRED1 Gene

Orthologs for SPRED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPRED1 29 30
  • 99.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPRED1 29 30
  • 95.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPRED1 29 30
  • 93.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spred1 29 16 30
  • 91.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spred1 29
  • 90.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia SPRED1 30
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SPRED1 30
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SPRED1 29 30
  • 83.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPRED1 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spred1 29
  • 67.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii spred1 29 30
  • 62.21 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Spred 30
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10713 30
  • 25 (a)
OneToMany
Species where no ortholog for SPRED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPRED1 Gene

ENSEMBL:
Gene Tree for SPRED1 (if available)
TreeFam:
Gene Tree for SPRED1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPRED1: view image
Alliance of Genome Resources:
Additional Orthologs for SPRED1

Paralogs for SPRED1 Gene

Paralogs for SPRED1 Gene

(3) SIMAP similar genes for SPRED1 Gene using alignment to 3 proteins:

  • SPRE1_HUMAN
  • H0YMN8_HUMAN
  • L8EBE5_HUMAN
genes like me logo Genes that share paralogs with SPRED1: view

Variants for SPRED1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPRED1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
1004068 Uncertain Significance: Legius syndrome 38,339,824(+) T/C
NM_152594.3(SPRED1):c.511T>C (p.Ser171Pro)
MISSENSE
1004532 Uncertain Significance: Legius syndrome 38,322,338(+) C/A
NM_152594.3(SPRED1):c.305C>A (p.Thr102Lys)
MISSENSE
1006489 Uncertain Significance: Legius syndrome 38,339,764(+) C/G
NM_152594.3(SPRED1):c.451C>G (p.Leu151Val)
MISSENSE
1013780 Uncertain Significance: Legius syndrome 38,349,498(+) G/A
NM_152594.3(SPRED1):c.659G>A (p.Cys220Tyr)
MISSENSE
1015670 Uncertain Significance: Legius syndrome 38,324,814(+) G/A
NM_152594.3(SPRED1):c.423+5G>A
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPRED1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPRED1 Gene

Variant ID Type Subtype PubMed ID
esv3892674 CNV gain 25118596
esv6112 CNV gain 19470904
nsv1050521 CNV loss 25217958
nsv510394 OTHER sequence alteration 20534489
nsv569204 CNV loss 21841781
nsv832973 CNV gain 17160897
nsv832974 CNV loss 17160897
nsv94413 CNV deletion 16902084

Variation tolerance for SPRED1 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRED1 Gene

Human Gene Mutation Database (HGMD)
SPRED1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRED1
Leiden Open Variation Database (LOVD)
SPRED1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED1 Gene

Disorders for SPRED1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for SPRED1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
legius syndrome
  • lgss
neurofibromatosis
  • acoustic neurofibromatosis
neurofibromatosis-noonan syndrome
  • nfns
costello syndrome
  • cstlo
mucosal melanoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SPRE1_HUMAN
  • Legius syndrome (LGSS) [MIM:611431]: An autosomal dominant syndrome characterized mainly by cafe-au-lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities, and features of attention-deficit hyperactivity disorder. {ECO:0000269 PubMed:17704776, ECO:0000269 PubMed:19443465, ECO:0000269 PubMed:20108422, ECO:0000269 PubMed:21089071}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for SPRED1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SPRED1: view

No data available for Genatlas for SPRED1 Gene

Publications for SPRED1 Gene

  1. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PMID: 19443465) Spurlock G … Upadhyaya M (Journal of medical genetics 2009) 3 4 40
  2. Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. (PMID: 19920235) Messiaen L … Legius E (JAMA 2009) 3 22 40
  3. Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. (PMID: 17704776) Brems H … Legius E (Nature genetics 2007) 3 4 72
  4. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. (PMID: 16115197) Nonami A … Yoshimura A (Genes to cells : devoted to molecular & cellular mechanisms 2005) 3 4 22
  5. Family with Legius syndrome (neurofibromatosis type 1-like syndrome). (PMID: 25981987) Sakai N … Mitsuhashi Y (The Journal of dermatology 2015) 3 72

Products for SPRED1 Gene

Sources for SPRED1 Gene