Free for academic non-profit institutions. Other users need a Commercial license
Aliases for SPPL3 Gene
Aliases for SPPL3 Gene
External Ids for SPPL3 Gene
- HGNC: 30424
- Entrez Gene: 121665
- Ensembl: ENSG00000157837
- OMIM: 608240
- UniProtKB: Q8TCT6
Previous GeneCards Identifiers for SPPL3 Gene
- GC12P119943
- GC12M120799
- GC12M120983
- GC12M119612
- GC12M119663
- GC12M121201
- GC12M118210
- GC12M121202
- GC12M121210
- GC12M121231
- GC12M121252
- GC12M120951
- GC12M120975
- GC12M120801
- GC12M120819
- GC12M120840
- GC12M120862
- GC12M120882
- GC12M120905
- GC12M120928
Summaries for SPPL3 Gene
GeneCards Summary for SPPL3 Gene
SPPL3 (Signal Peptide Peptidase Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic endopeptidase activity, intramembrane cleaving. An important paralog of this gene is SPPL2B.
UniProtKB/Swiss-Prot Summary for SPPL3 Gene
-
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
Additional gene information for SPPL3 Gene
- Monarch Initiative
- Search for SPPL3 at DataMed
- Search for SPPL3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPPL3 Gene
Genomics for SPPL3 Gene
GeneHancer (GH) Regulatory Elements for SPPL3 Gene
Promoters and enhancers for SPPL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPPL3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SPPL3 gene promoter:
-
- AP-2beta
- CUTL1
- FOXO4
- p53
- POU2F1
- POU2F1a
- STAT1
- STAT1alpha
- STAT1beta
- ZID
Genomic Locations for SPPL3 Gene
Genomic Locations for SPPL3 Gene
- chr12:120,762,510-120,904,358
- (GRCh38/hg38)
- Size:
- 141,849 bases
- Orientation:
- Minus strand
- chr12:121,200,313-121,342,174
- (GRCh37/hg19)
- Size:
- 141,862 bases
- Orientation:
- Minus strand
Genomic View for SPPL3 Gene
Genes around SPPL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
SPPL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPPL3 Gene
Proteins for SPPL3 Gene
-
Protein details for SPPL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCT6-SPPL3_HUMAN
- Recommended name:
- Signal peptide peptidase-like 3
- Protein Accession:
- Q8TCT6
- Q3MJ04
- Q8TAU4
- Q96DD9
Protein attributes for SPPL3 Gene
- Size:
- 384 amino acids
- Molecular mass:
- 42261 Da
- Quaternary structure:
-
- Monomer (PubMed:15385547, PubMed:15998642, PubMed:16873890). Homodimer (PubMed:15385547, PubMed:15998642, PubMed:16873890). Interacts with STIM1 (via the transmembrane region and the SOAR/CAD domain); the interaction promotes the binding of STIM1 to ORAI1 (PubMed:25384971). Interacts with the simian foamy virus envelope glycoprotein gp130 and its processed leader peptide gp18LP; preferentially interacts with the envelope glycoprotein gp130 (PubMed:23132852).
- SequenceCaution:
-
- Sequence=BAC11290.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SPPL3 Gene
Post-translational modifications for SPPL3 Gene
- Not glycosylated (PubMed:15385547, PubMed:15998642).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SPPL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-SPPL3 Antibody (HPA059958) and Anti-SPPL3 Antibody (HPA004194)
- Creative Diagnostics Anti-SPPL3 monoclonal antibody, Anti-SPPL3 (aa 212-262) polyclonal antibody, and Anti-SPPL3 (aa 58-88) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for SPPL3
- Novus Biologicals Antibodies for SPPL3
- Invitrogen Antibodies for SPPL3 (AFLGC-SPPL3)
Protein Products
- Atlas Antibodies PrEST Antigen SPPL3 (APrEST85617) and PrEST Antigen SPPL3 (APrEST90554)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPPL3
- Origene Custom Protein Services for SPPL3
- Novus Biologicals proteins for SPPL3
-
Abcam proteins for SPPL3
No data available for DME Specific Peptides for SPPL3 Gene
Domains & Families for SPPL3 Gene
Gene Families for SPPL3 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for SPPL3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPPL3 Gene
- GenScript: Design optimal peptide antigens:
-
- Presenilin-like protein 4 (PSL4_HUMAN)
- Signal peptide peptidase-like protein 3 protein (Q3MJ04_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TCT6UniProtKB/Swiss-Prot:
SPPL3_HUMAN :- The first transmembrane domain may act as a type I signal anchor (PubMed:15385547). The catalytic loops is exposed toward the lumen (PubMed:15385547). The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family (By similarity).
- Belongs to the peptidase A22B family.
- Domain:
-
- The first transmembrane domain may act as a type I signal anchor (PubMed:15385547). The catalytic loops is exposed toward the lumen (PubMed:15385547). The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family (By similarity).
- Family:
-
- Belongs to the peptidase A22B family.
Function for SPPL3 Gene
Molecular function for SPPL3 Gene
- UniProtKB/Swiss-Prot Function:
- Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Its proteolytic activity is blocked by a signal peptide peptidase (SPP) inhibitor, (ZLL)2-ketone (ZLL) or a gamma-secretase inhibitor, LY411,575 (PubMed:16873890). However, is not inhibited by ZLL and LY411,575 for activity on simian foamy virus envelope glycoprotein gp130 (PubMed:23132852).
Enzyme Numbers (IUBMB) for SPPL3 Gene
Phenotypes From GWAS Catalog for SPPL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 2313285 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving | IMP,IBA | 16873890 |
| GO:0042803 | protein homodimerization activity | IDA | 15385547 |
Phenotypes for SPPL3 Gene
- MGI mutant phenotypes for SPPL3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SPPL3:
Animal Model Products
-
Taconic Biosciences Mouse Models for SPPL3
CRISPR Products
-
OriGene CRISPR knockouts for SPPL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPPL3
- genomics-online: gRNA clones - Search for available SPPL3 gRNA products
- Overview of 70 available SPPL3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SPPL3 - Select products 50% OFF >
- * SPPL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SPPL3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPPL3
miRNA for SPPL3 Gene
- miRTarBase miRNAs that target SPPL3
-
- hsa-mir-190a-3p (MIRT112592)
- hsa-mir-5011-5p (MIRT112596)
- hsa-mir-568 (MIRT335505)
- hsa-mir-21-5p (MIRT439550)
- hsa-mir-653-3p (MIRT495401)
- hsa-mir-4420 (MIRT495402)
- hsa-mir-181b-3p (MIRT495403)
- hsa-mir-181b-2-3p (MIRT495404)
- hsa-mir-6886-3p (MIRT495405)
- hsa-mir-5189-3p (MIRT495406)
- hsa-mir-938 (MIRT495407)
- hsa-mir-6780b-3p (MIRT495408)
- hsa-mir-6890-3p (MIRT495409)
- hsa-mir-6809-5p (MIRT534085)
- hsa-mir-3613-3p (MIRT534086)
- hsa-mir-605-5p (MIRT534087)
- hsa-mir-4455 (MIRT544529)
- hsa-mir-6083 (MIRT544530)
- hsa-mir-1277-5p (MIRT544531)
- hsa-mir-3924 (MIRT544532)
- hsa-mir-511-3p (MIRT544533)
- hsa-mir-6867-5p (MIRT544534)
- hsa-mir-5007-3p (MIRT551017)
- hsa-mir-664a-3p (MIRT551018)
- hsa-mir-3163 (MIRT551019)
- hsa-mir-1537-3p (MIRT551020)
- hsa-mir-548ay-3p (MIRT551021)
- hsa-mir-548at-3p (MIRT551022)
- hsa-mir-548x-3p (MIRT551023)
- hsa-mir-548j-3p (MIRT551024)
- hsa-mir-548aq-3p (MIRT551025)
- hsa-mir-548am-3p (MIRT551026)
- hsa-mir-548aj-3p (MIRT551027)
- hsa-mir-548ah-3p (MIRT551028)
- hsa-mir-548ae-3p (MIRT551029)
- hsa-mir-548z (MIRT551030)
- hsa-mir-548h-3p (MIRT551031)
- hsa-mir-548d-3p (MIRT551032)
- hsa-mir-548bb-3p (MIRT551033)
- hsa-mir-548ac (MIRT551034)
- hsa-mir-3591-5p (MIRT653167)
- hsa-mir-335-3p (MIRT653168)
- hsa-mir-4639-5p (MIRT653169)
- hsa-mir-4775 (MIRT653170)
- hsa-mir-4735-5p (MIRT653171)
- hsa-mir-5196-3p (MIRT653172)
- hsa-mir-4793-5p (MIRT653173)
- hsa-mir-501-5p (MIRT653174)
- hsa-mir-4255 (MIRT653175)
- hsa-mir-590-3p (MIRT653176)
- hsa-mir-142-3p (MIRT653177)
- hsa-mir-1303 (MIRT671942)
- hsa-mir-5096 (MIRT671943)
- hsa-mir-6848-3p (MIRT671944)
- hsa-mir-6843-3p (MIRT671945)
- hsa-mir-3187-3p (MIRT671946)
- hsa-mir-4435 (MIRT671947)
- hsa-mir-588 (MIRT671948)
- hsa-mir-4701-5p (MIRT671949)
- hsa-mir-548s (MIRT671950)
- hsa-mir-516a-5p (MIRT671951)
- hsa-mir-197-3p (MIRT671952)
- hsa-mir-193b-5p (MIRT671953)
- hsa-mir-6131 (MIRT671954)
- hsa-mir-4755-3p (MIRT671955)
- hsa-mir-3663-5p (MIRT671956)
- hsa-mir-150-5p (MIRT671957)
- hsa-mir-4716-5p (MIRT671958)
- hsa-mir-4781-3p (MIRT671959)
- hsa-mir-483-5p (MIRT671960)
- hsa-mir-4762-3p (MIRT698901)
- hsa-mir-4303 (MIRT698902)
- hsa-mir-1911-5p (MIRT698903)
- hsa-mir-4682 (MIRT698904)
- hsa-mir-624-5p (MIRT698905)
- hsa-mir-6768-5p (MIRT698906)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SPPL3
- Browse OriGene Inhibitory RNA Products For SPPL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPPL3
- genomics-online: shRNA clones - Search for available SPPL3 shRNA products
- Overview of 70 available SPPL3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SPPL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPPL3
- genomics-online: cdna clones - Search for available SPPL3 CDNA products
- Overview of 70 available SPPL3 gene related products
- orf clones - Search for available SPPL3 ORF products
- Overview of 70 available SPPL3 gene related products
- Applied Biological Materials (abm): Clones for SPPL3 - Select products 50% OFF >
- * SPPL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SPPL3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for SPPL3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPPL3 Gene
Localization for SPPL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPPL3 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus. Membrane; Multi-pass membrane protein; Lumenal side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 3 |
| endosome | 1 |
| lysosome | 1 |
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005791 | rough endoplasmic reticulum | IDA | 15998642 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for SPPL3 Gene
Interacting Proteins for SPPL3 Gene
GPS-Prot Interaction Network for SPPL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006465 | signal peptide processing | IBA | 21873635 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006509 | NOT membrane protein ectodomain proteolysis | IMP | 16829952 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISS,IEA | -- |
| GO:0032092 | positive regulation of protein binding | ISS,IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPPL3 Gene
Drugs & Compounds for SPPL3 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen SPPL3 (APrEST85617) and PrEST Antigen SPPL3 (APrEST90554)
Transcripts for SPPL3 Gene
mRNA/cDNA for SPPL3 Gene
- (1) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (289) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000353487 4135 bps (ENST00000353487.6)
- ENST00000392495 2265 bps (ENST00000392495.7)
- ENST00000534966 868 bps (ENST00000534966.1)
- ENST00000536996 763 bps (ENST00000536996.5)
- ENST00000540091 531 bps (ENST00000540091.1)
CRISPR Products
-
OriGene CRISPR knockouts for SPPL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPPL3
- genomics-online: gRNA clones - Search for available SPPL3 gRNA products
- Overview of 70 available SPPL3 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SPPL3 - Select products 50% OFF >
- * SPPL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SPPL3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPPL3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SPPL3
- Browse OriGene Inhibitory RNA Products For SPPL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPPL3
- genomics-online: shRNA clones - Search for available SPPL3 shRNA products
- Overview of 70 available SPPL3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SPPL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPPL3
- genomics-online: cdna clones - Search for available SPPL3 CDNA products
- Overview of 70 available SPPL3 gene related products
- orf clones - Search for available SPPL3 ORF products
- Overview of 70 available SPPL3 gene related products
- Applied Biological Materials (abm): Clones for SPPL3 - Select products 50% OFF >
- * SPPL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SPPL3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for SPPL3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPPL3 Gene
NURSA nuclear receptor signaling pathways regulating expression of SPPL3 Gene:
SPPL3SOURCE GeneReport for Unigene cluster for SPPL3 Gene:
Hs.507087mRNA Expression by UniProt/SwissProt for SPPL3 Gene:
Q8TCT6-SPPL3_HUMAN
Tissue specificity:
Widely expressed (PubMed:15385547). Expressed in the brain (PubMed:11978763).
Evidence on tissue expression from TISSUES for SPPL3 Gene
- Nervous system(4.7)
- Liver(4.2)
- Pancreas(4.2)
- Blood(4)
Primer Products
-
OriGene qPCR primer pairs for SPPL3
-
OriGene qPCR primer pairs and template standards for SPPL3
- genomics-online: primer clones - Search for available SPPL3 Primer products
- Overview of 70 available SPPL3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPPL3 Gene
Orthologs for SPPL3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPPL3 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPPL3 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SPPL3 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SPPL3 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Sppl3 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sppl3 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPPL3 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPPL3 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SPPL3 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sppl3 32 |
|
||
| MGC75937 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52975 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sppl3 33 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG17370 34 |
|
|
|
| SppL 32 |
|
||||
| Sppl 33 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003207 32 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SPPL1 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os10g0393100 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3487 33 |
|
OneToOne | |
| Cin.10348 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10348 32 |
|
- Species where no ortholog for SPPL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SPPL3 Gene
- ENSEMBL:
- Gene Tree for SPPL3 (if available)
- TreeFam:
- Gene Tree for SPPL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPPL3: view image
Paralogs for SPPL3 Gene
Variants for SPPL3 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000061871 | -- | 120,876,292(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000101528 | -- | 120,838,422(-) | G/A | intron_variant | |
| rs1000137310 | -- | 120,773,023(-) | G/C | intron_variant | |
| rs1000148568 | -- | 120,809,013(-) | G/A | intron_variant | |
| rs1000150823 | -- | 120,812,536(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2915n54 | CNV | gain | 21841781 |
| dgv2916n54 | CNV | loss | 21841781 |
| dgv2917n54 | CNV | gain | 21841781 |
| dgv2918n54 | CNV | loss | 21841781 |
| esv1190904 | CNV | deletion | 17803354 |
| esv1624453 | CNV | insertion | 17803354 |
| esv23186 | CNV | loss | 19812545 |
| esv2591284 | CNV | deletion | 19546169 |
| esv2672947 | CNV | deletion | 23128226 |
| esv2746478 | CNV | deletion | 23290073 |
| esv2763007 | CNV | loss | 21179565 |
| esv3630932 | CNV | loss | 21293372 |
| nsv1045178 | CNV | gain | 25217958 |
| nsv1070133 | CNV | deletion | 25765185 |
| nsv1144659 | CNV | deletion | 24896259 |
| nsv521928 | CNV | gain | 19592680 |
| nsv560438 | CNV | gain | 21841781 |
| nsv560439 | CNV | loss | 21841781 |
| nsv560440 | CNV | loss | 21841781 |
| nsv560442 | CNV | loss | 21841781 |
| nsv560450 | CNV | gain+loss | 21841781 |
| nsv908 | CNV | insertion | 18451855 |
| nsv957924 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPPL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPPL3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPPL3 Gene
Disorders for SPPL3 Gene
Additional Disease Information for SPPL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SPPL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPPL3 Gene
Publications for SPPL3 Gene
- Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. (PMID: 16873890) Nyborg AC … Golde TE (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3 4 23 56
- Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PMID: 15385547) Friedmann E … Martoglio B (The Journal of biological chemistry 2004) 3 4 23 56
- Novel class of polytopic proteins with domains associated with putative protease activity. (PMID: 12139484) Grigorenko AP … Rogaev EI (Biochemistry. Biokhimiia 2002) 2 3 4 56
- A protease-independent function for SPPL3 in NFAT activation. (PMID: 25384971) Makowski SL … Pomerantz JL (Molecular and cellular biology 2015) 3 4 56
- Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. (PMID: 25827571) Kuhn PH … Fluhrer R (Molecular & cellular proteomics : MCP 2015) 3 4 56
ExternalLinks
Products for SPPL3 Gene
- Custom Antibody ServicesOriGene Antibodies for SPPL3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SPPL3
- Origene Custom Protein Services for SPPL3
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SPPL3
- Browse OriGene Inhibitory RNA Products For SPPL3
- OriGene qPCR primer pairs for SPPL3
- OriGene qPCR primer pairs and template standards for SPPL3
- OriGene CRISPR knockouts for SPPL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPPL3
- Sino Biological Human cDNA Clone for SPPL3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPPL3
- Novus Biologicals proteins for SPPL3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SPPL3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SPPL3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SPPL3 (AFLGC-SPPL3)
- antibodies-online: Show 10 available SPPL3 Antibodies ranked by validation data
- Compare Top SPPL3 Antibodies
- antibodies-online: Search results for available SPPL3 related products ranked by validation data
- antibodies-online: Search results for available SPPL3 related products ranked by validation data
- Horizon Cell Lines for SPPL3
- genomics-online: cdna clones - Search for available SPPL3 CDNA products
- Overview of 70 available SPPL3 gene related products
- orf clones - Search for available SPPL3 ORF products
- Overview of 70 available SPPL3 gene related products
- genomics-online: gRNA clones - Search for available SPPL3 gRNA products
- Overview of 70 available SPPL3 gene related products
- genomics-online: primer clones - Search for available SPPL3 Primer products
- Overview of 70 available SPPL3 gene related products
- genomics-online: shRNA clones - Search for available SPPL3 shRNA products
- Overview of 70 available SPPL3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPPL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPPL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SPPL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPPL3
Sources for SPPL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource