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SPPL3 (Signal Peptide Peptidase Like 3) is a Protein Coding gene. Diseases associated with SPPL3 include Plasmodium Ovale Malaria and Frontometaphyseal Dysplasia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic endopeptidase activity, intramembrane cleaving. An important paralog of this gene is SPPL2B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004190 | aspartic-type endopeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 2313285 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving | IBA,IMP | 16873890 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005791 | rough endoplasmic reticulum | IDA | 15998642 |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006465 | signal peptide processing | IBA | 21873635 |
GO:0006508 | proteolysis | IEA | -- |
GO:0006509 | NOT membrane protein ectodomain proteolysis | IMP | 16829952 |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA,ISS | -- |
GO:0032092 | positive regulation of protein binding | IEA,ISS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SPPL3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SPPL3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SPPL3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SPPL3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sppl3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sppl3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SPPL3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SPPL3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SPPL3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sppl3 30 |
|
||
MGC75937 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC52975 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sppl3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17370 32 |
|
|
|
SppL 30 |
|
||||
Sppl 31 |
|
OneToOne | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003207 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SPPL1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0393100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3487 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10348 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2915n54 | CNV | gain | 21841781 |
dgv2916n54 | CNV | loss | 21841781 |
dgv2917n54 | CNV | gain | 21841781 |
dgv2918n54 | CNV | loss | 21841781 |
esv1190904 | CNV | deletion | 17803354 |
esv1624453 | CNV | insertion | 17803354 |
esv23186 | CNV | loss | 19812545 |
esv2591284 | CNV | deletion | 19546169 |
esv2672947 | CNV | deletion | 23128226 |
esv2746478 | CNV | deletion | 23290073 |
esv2763007 | CNV | loss | 21179565 |
esv3630932 | CNV | loss | 21293372 |
nsv1045178 | CNV | gain | 25217958 |
nsv1070133 | CNV | deletion | 25765185 |
nsv1144659 | CNV | deletion | 24896259 |
nsv521928 | CNV | gain | 19592680 |
nsv560438 | CNV | gain | 21841781 |
nsv560439 | CNV | loss | 21841781 |
nsv560440 | CNV | loss | 21841781 |
nsv560442 | CNV | loss | 21841781 |
nsv560450 | CNV | gain+loss | 21841781 |
nsv908 | CNV | insertion | 18451855 |
nsv957924 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
plasmodium ovale malaria |
|
|
frontometaphyseal dysplasia |
|
|