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The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-g... See more...
Aliases for SPP1 Gene
Aliases for SPP1 Gene
- OPN 3 4
- Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1) 3
- Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein 3
- Secreted Phosphoprotein 1 Variant 6 3
- Bone Sialoprotein I 2
- SPP1/CALPHA1 Fusion 3
- Bone Sialoprotein 1 4
- SPP-1 4
- SPP1 5
External Ids for SPP1 Gene
- HGNC: 11255
- NCBI Entrez Gene: 6696
- Ensembl: ENSG00000118785
- OMIM®: 166490
- UniProtKB/Swiss-Prot: P10451
Previous HGNC Symbols for SPP1 Gene
- BNSP
- OPN
Previous GeneCards Identifiers for SPP1 Gene
- GC04P089054
- GC04P089198
- GC04P089355
- GC04P089253
- GC04P089115
- GC04P088896
- GC04P084643
Summaries for SPP1 Gene
-
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SPP1 Gene
SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Urolithiasis. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and extracellular matrix binding.
UniProtKB/Swiss-Prot Summary for SPP1 Gene
-
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
-
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Additional gene information for SPP1 Gene
- HGNC (11255)
- NCBI Entrez Gene (6696)
- Ensembl (ENSG00000118785)
- OMIM® (166490)
- UniProtKB/Swiss-Prot (P10451)
- Open Targets Platform(ENSG00000118785)
- Monarch Initiative
- Search for SPP1 at DataMed
- Search for SPP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPP1 Gene
Genomics for SPP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SPP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPP1
- Top Transcription factor binding sites by QIAGEN in the SPP1 gene promoter:
-
- AML1a
Genomic Locations for SPP1 Gene
Latest Assembly
- chr4:87,975,650-87,983,426
- (GRCh38/hg38)
- Size:
- 7,777 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:88,896,866-88,904,563
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,698 bases
- Orientation:
- Plus strand
- chr4:88,896,819-88,904,562
- (GRCh37/hg19 by Ensembl)
- Size:
- 7,744 bases
- Orientation:
- Plus strand
Genomic View for SPP1 Gene
Genes around SPP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q22.1 by HGNC
- 4q22.1 by Entrez Gene
- 4q22.1 by Ensembl
SPP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPP1 Gene
Proteins for SPP1 Gene
-
Protein details for SPP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10451-OSTP_HUMAN
- Recommended name:
- Osteopontin
- Protein Accession:
- P10451
- B2RDA1
- Q15681
- Q15682
- Q15683
- Q4W597
- Q567T5
- Q8NBK2
- Q96IZ1
Protein attributes for SPP1 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 35423 Da
- Quaternary structure:
-
- Ligand for integrin alpha-V/beta-3.
Protein Expression for SPP1 Gene
Post-translational modifications for SPP1 Gene
- Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
- O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
-
Glycosylation at Thr134, Thr138, Thr143, Thr147, and Thr152
- NX_P10451 (NX_P10451-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- OSTP_HUMAN (474)
Other Protein References for SPP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SPP1 / Osteopontin Antibody and SPP1 / Osteopontin Monoclonal Antibody
- G Biosciences Immunotag™ Osteopontin Antibody and Immunotag™ SPP1 Antibody
- NSJ Bioreagents OPN Antibody
- BioLegend Osteopontin (SPP1) Antibody
-
Custom Antibody ServicesOriGene Antibodies for SPP1
- AM31698PU-N
- AP02135SU-N
- AP02135SU-S
- AP02136SU-N
- AP02136SU-S
- AP06258PU-N
- AP31180PU-N
- AP52999PU-N
- CF806238
- CF806260
- CF806722
- CF806770
- CF806784
- R1565
- TA303040
- TA309877
- TA318038
- TA323620
- TA323621
- TA326117
- TA326641
- TA327038
- TA347445
- TA354257
- TA354515
- TA590059
- TA806238
- TA806238S
- TA806260
- TA806260S
- TA806722
- TA806722S
- TA806770
- TA806770S
- TA806784
- TA806784S
- Novus Biologicals Antibodies for SPP1
-
Abcam antibodies for SPP1
- Invitrogen Antibodies for SPP1 (AFLGC-SPP1)
- antibodies-online: Show 112 available Osteopontin Antibodies ranked by validation data
- Compare Top Osteopontin Antibodies
-
Recommended
- 324 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 82 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 70 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPP1
- Sino Biological Antibodies for SPP1
Protein products for research
- G Biosciences Human Osteopontin/OPN/SPP-1/SPP1, Lyophilized
- RayBiotech Recombinant Human Osteopontin
- Search Origene for MassSpec and Protein Over-expression Lysates for SPP1
- Origene Custom Protein Services for SPP1
- Sino Biological Recombinant Proteins for SPP1
- Sino Biological Cell Lysates for SPP1
- ProSpec Recombinant Proteins for SPP1
-
ProSci Proteins for SPP1
-
Abcam proteins for SPP1
Assay products for research
- G Biosciences Immunotag™ Human OPN (Osteopontin) ELISA and Immunotag™ Osteopontin ELISA Kit
- RayBiotech Human Osteopontin (OPN) ELISA
- Novus Biologicals ELISA Kits for SPP1
- antibodies-online: Show 146 available Osteopontin Elisa Kits ranked by validation data
- Compare Top Osteopontin Elisa Kits
-
Quality Products:
- ABIN625068
- ABIN2815075
- ABIN414433
- ABIN368347
- ABIN1116329
- ABIN411343
- ABIN492191
- ABIN3032973
- ABIN1380042
- ABIN3198472
- ABIN415404
- ABIN1116328
- ABIN411344
- ABIN2685512
- ABIN4993187
- ABIN492192
- ABIN625171
- ABIN1029448
- ABIN2748453
- ABIN3198473
- ABIN1116330
- ABIN367452
- ABIN416115
- ABIN5563541
- ABIN1571671
- ABIN5525068
- ABIN2685513
- ABIN579095
- ABIN5670948
- ABIN414180
- ABIN1029446
- ABIN4947920
- ABIN364685
- ABIN511177
- ABIN5657550
- ABIN5657549
- ABIN2537449
- ABIN6231100
- ABIN6231099
-
Abcam assays for SPP1
No data available for DME Specific Peptides for SPP1 Gene
Domains & Families for SPP1 Gene
Gene Families for SPP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for SPP1 Gene
- InterPro:
- Blocks:
-
- Osteopontin
- ProtoNet:
Suggested Antigen Peptide Sequences for SPP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ96520, Homo sapiens secreted phosphoprotein 1 (osteopontin, bonesialoprotein I, early T-lymphocyte activation 1) (SPP1), mRNA (B2RDA1_HUMAN)
- Osteopontin (C4B6Q2_HUMAN)
- Uropontin (OSTP_HUMAN)
- cDNA FLJ78337, highly similar to Homo sapiens secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), transcript variant 1, mRNA (Q4W597_HUMAN)
- cDNA FLJ77801 (Q567T5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10451- Family:
-
- Belongs to the osteopontin family.
Function for SPP1 Gene
Molecular function for SPP1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
- UniProtKB/Swiss-Prot Function:
- Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
- GENATLAS Biochemistry:
- secreted phosphoprotein 1 (osteopontin),regulated by CBFA1 and ETS1 in the skeletal tissue
Phenotypes From GWAS Catalog for SPP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005178 | integrin binding | IPI | 25839998 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0050840 | extracellular matrix binding | IBA | 21873635 |
Phenotypes for SPP1 Gene
- MGI mutant phenotypes for SPP1:
-
inferred from 6 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for SPP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Decreased viability with paclitaxel
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), polylobed nuclei, dynamic nuclei (hole, folded or small irregular)
- Decreased CXCL12 induced migration
Animal Models for SPP1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for SPP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SPP1 - Starting at $85 >
- * SPP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SPP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPP1
miRNA for SPP1 Gene
- miRTarBase miRNAs that target SPP1
-
- hsa-miR-299-5p (MIRT004565)
- mmu-miR-124-3p (MIRT015953)
- hsa-miR-335-5p (MIRT016866)
- hsa-miR-146a-5p (MIRT021279)
- mmu-miR-27a-3p (MIRT054435)
- mmu-miR-181c-5p (MIRT580760)
- mmu-miR-181a-5p (MIRT580761)
- mmu-miR-181b-5p (MIRT580762)
- mmu-miR-181d-5p (MIRT580763)
- mmu-miR-377-3p (MIRT580764)
- mmu-miR-340-5p (MIRT580765)
- mmu-miR-3065-5p (MIRT580766)
- hsa-miR-181b-5p (MIRT732307)
- hsa-miR-127-5p (MIRT735286)
- hsa-miR-4262 (MIRT735411)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPP1
- Browse OriGene Inhibitory RNA Products For SPP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPP1
Clone products for research
- Applied Biological Materials (abm): Clones for SPP1 - Starting at $45 >
- * SPP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226579
- MR226579
- MR226579L3
- MR226579L4
- MR229068
- MR229079
- MR229165
- MR229168
- RC204803
- RC204803L1
- RC204803L2
- RC204803L3
- RC204803L4
- RC205118
- RC205118L1
- RC205118L2
- RC205118L3
- RC205118L4
- RC210592
- RC210592L1
- RC210592L2
- RC210592L3
- RC210592L4
- RC233612
- RC233777
- RG204803
- RG205118
- RG210592
- RG233612
- RG233777
- RR208248
- RR208248L3
- RR208248L4
- MR226579L3V
- MR226579L4V
- RC204803L1V
- RC204803L2V
- RC204803L3V
- RC204803L4V
- RC205118L1V
- RC205118L2V
- RC205118L3V
- RC205118L4V
- RC210592L1V
- RC210592L2V
- RC210592L3V
- RC210592L4V
- RR208248L3V
- RR208248L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SPP1
- Addgene plasmids for SPP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPP1
Cell Lines for research
- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor and PureStem SK11, NCr-fac & Meso-prx Progenitor for SPP1
-
Horizon Cell Lines for SPP1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPP1 Gene
Localization for SPP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPP1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 15516325 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0031982 | vesicle | IEA | -- |
Pathways & Interactions for SPP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | ECM-receptor interaction | ||
| 5 | Focal Adhesion |
.61
|
.61
|
Pathways by source for SPP1 Gene
13 BioSystems pathways for SPP1 Gene
5 Reactome pathways for SPP1 Gene
7 KEGG pathways for SPP1 Gene
2 GeneGo (Thomson Reuters) pathways for SPP1 Gene
- Development_Hedgehog and PTH signaling pathways in bone and cartilage development
- Transcription_Role of VDR in regulation of genes involved in osteoporosis
1 R&D Systems pathway for SPP1 Gene
15 Qiagen pathways for SPP1 Gene
- ERK Signaling
- FAK1 Signaling
- GnRH Signaling
- ILK Signaling
- Inhibition of Angiogenesis by TSP1
Interacting Proteins for SPP1 Gene
Selected Interacting proteins:
P10451-OSTP_HUMAN
ENSP00000378517
for SPP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SPP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001503 | ossification | IEA | -- |
| GO:0001649 | osteoblast differentiation | IBA | 21873635 |
| GO:0006710 | androgen catabolic process | IDA | 26482249 |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007155 | cell adhesion | IDA | 25839998 |
Drugs & Compounds for SPP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Osteopontin/OPN/SPP-1/SPP1, Lyophilized
- RayBiotech Recombinant Human Osteopontin
Transcripts for SPP1 Gene
mRNA/cDNA for SPP1 Gene
- 5 REFSEQ mRNAs :
- 34 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000237623 1581 nts (view in UCSC)
- ENST00000360804 1196 nts (view in UCSC)
- ENST00000395080 1561 nts (view in UCSC)
- ENST00000504310 557 nts (view in UCSC)
- ENST00000505146 252 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SPP1 - Starting at $85 >
- * SPP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SPP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPP1
- Browse OriGene Inhibitory RNA Products For SPP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPP1
Clone products for research
- Applied Biological Materials (abm): Clones for SPP1 - Starting at $45 >
- * SPP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG226579
- MR226579
- MR226579L3
- MR226579L4
- MR229068
- MR229079
- MR229165
- MR229168
- RC204803
- RC204803L1
- RC204803L2
- RC204803L3
- RC204803L4
- RC205118
- RC205118L1
- RC205118L2
- RC205118L3
- RC205118L4
- RC210592
- RC210592L1
- RC210592L2
- RC210592L3
- RC210592L4
- RC233612
- RC233777
- RG204803
- RG205118
- RG210592
- RG233612
- RG233777
- RR208248
- RR208248L3
- RR208248L4
- MR226579L3V
- MR226579L4V
- RC204803L1V
- RC204803L2V
- RC204803L3V
- RC204803L4V
- RC205118L1V
- RC205118L2V
- RC205118L3V
- RC205118L4V
- RC210592L1V
- RC210592L2V
- RC210592L3V
- RC210592L4V
- RR208248L3V
- RR208248L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SPP1
- Addgene plasmids for SPP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPP1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | - | - |
Relevant External Links for SPP1 Gene
- GeneLoc Exon Structure for
- SPP1
Expression for SPP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Fusing Suture Cells Rostral Sutures
- Immature Endochondral Osteoblasts Vertebrae
- Hypertrophic Chondrocytes Vertebrae
- Terminal Chondrocytes Caudal Facial Endochondral Bones
- Terminal Chondrocytes Mandibular Condyle
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Terminal Chondrocytes Caudal Facial Endochondral Bones
- Terminal Chondrocytes Mandibular Condyle
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Distal Tubule Cells Distal Tubule
- Loop of Henle
- Distal Tubule
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Distal Tubule Cells Distal Tubule
-
Tooth (Integumentary System)
- Cementoblasts Cementum
- Dental Papilla Cells Dental Papilla
- Dentin
- Cementum
- Stem cells from human exfoliated deciduous teeth (family)
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
- Hypothalamus
- Thalamus
- Medulla Oblongata
- Cerebral Cortex
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
- Islets of Langerhans
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Liver (Hepatobiliary System)
- Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
- Biliary Epithelial Cells Intrahepatic Biliary Tree
- Neural Crest (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
- Epiblast (Early Embryonic Tissues)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesoderm (Gastrulation Derivatives)
- NULL (Uncategorized)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spinal Cord (Nervous System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for SPP1 Gene
This gene is overexpressed in Kidney - Cortex (x18.1), Brain - Spinal cord (cervical c-1) (x9.2), and Brain - Substantia nigra (x5.7).
This gene is overexpressed in Urine (29.6), Milk (15.5), Amniocyte (10.7), and Cerebrospinal fluid (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPP1
SOURCE GeneReport for Unigene cluster for SPP1 Gene:
Hs.313mRNA Expression by UniProt/SwissProt for SPP1 Gene:
P10451-OSTP_HUMAN
Tissue specificity:
Bone. Found in plasma.
Evidence on tissue expression from TISSUES for SPP1 Gene
- Nervous system(5)
- Kidney(5)
- Liver(4.8)
- Pancreas(4.6)
- Lung(4.3)
- Bone(4.1)
- Eye(4)
- Blood(3.9)
- Gall bladder(3.6)
- Skin(3.4)
- Heart(3.2)
- Intestine(3.1)
- Muscle(3)
- Bone marrow(2.8)
- Lymph node(2.7)
- Spleen(2.5)
- Urine(2.3)
- Thyroid gland(2.3)
- Adrenal gland(2.3)
- Stomach(2.2)
Primer products for research
-
OriGene qPCR primer pairs for SPP1
-
OriGene qPCR primer pairs and template standards for SPP1
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPP1 Gene
Orthologs for SPP1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SPP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SPP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SPP1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Spp1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Spp1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SPP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SPP1 31 |
|
OneToOne |
- Species where no ortholog for SPP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SPP1 Gene
- ENSEMBL:
- Gene Tree for SPP1 (if available)
- TreeFam:
- Gene Tree for SPP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPP1: view image
Paralogs for SPP1 Gene
(1) SIMAP similar genes for SPP1 Gene using alignment to 2 proteins:
- OSTP_HUMAN
- D6R9C5_HUMAN
No data available for Paralogs for SPP1 Gene
Variants for SPP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPP1 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs146552179 | Likely Benign: not provided | 87,981,552(+) |
C/A NM_001040058.2(SPP1):c.294C>A (p.Asp98Glu) |
MISSENSE | |
| rs1578104553 | Likely Benign: not provided | 87,982,890(+) |
C/G NM_001040058.2(SPP1):c.939C>G (p.Val313=) |
SYNONYMOUS | |
| rs34076181 | Benign: not provided | 87,982,686(+) |
A/G NM_001040058.2(SPP1):c.735A>G (p.Leu245=) |
SYNONYMOUS | |
| rs376158660 | Likely Benign: not provided | 87,981,496(+) |
G/A NM_001040058.2(SPP1):c.238G>A (p.Glu80Lys) |
MISSENSE | |
| rs4660 | -. Benign: not provided | 87,982,853(+) |
p.Arg301HisG/A |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2665331 | CNV | deletion | 23128226 |
| esv3893976 | CNV | loss | 25118596 |
| nsv7364 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.47;
64.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP1 Gene
Disorders for SPP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pediatric systemic lupus erythematosus |
|
|
| urolithiasis |
|
|
| dentin dysplasia |
|
|
| dentinogenesis imperfecta |
|
|
| calcinosis |
|
|
Search SPP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SPP1 Gene
Publications for SPP1 Gene
- The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis. (PMID: 20219412) Chiu YW … Kao SY (Oral oncology 2010) 3 23 41
- The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis. (PMID: 20144595) Liu CC … Wu MT (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23 41
- Association between osteopontin and human abdominal aortic aneurysm. (PMID: 17170369) Golledge J … Norman PE (Arteriosclerosis, thrombosis, and vascular biology 2007) 3 23 41
- No association between selected candidate gene polymorphisms and severe chronic periodontitis. (PMID: 16512757) Wohlfahrt JC … Michalowicz BS (Journal of periodontology 2006) 3 23 41
- Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. (PMID: 15869464) Christensen B … Sørensen ES (The Biochemical journal 2005) 3 4 23
ExternalLinks
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Sources for SPP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (44) Atlas
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- (64) Proteopedia
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
- (71) GenomeRNAi
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- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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