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Aliases for SPOPL Gene

Aliases for SPOPL Gene

  • Speckle Type BTB/POZ Protein Like 2 3 5
  • Roadkill Homolog 2 2 3 4
  • HIB Homolog 2 2 3 4
  • Speckle-Type POZ Protein-Like 2 3
  • BTBD33 3

External Ids for SPOPL Gene

Previous GeneCards Identifiers for SPOPL Gene

  • GC02P138977
  • GC02P139259
  • GC02P131251

Summaries for SPOPL Gene

GeneCards Summary for SPOPL Gene

SPOPL (Speckle Type BTB/POZ Protein Like) is a Protein Coding gene. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. An important paralog of this gene is SPOP.

UniProtKB/Swiss-Prot for SPOPL Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.

Additional gene information for SPOPL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOPL Gene

Genomics for SPOPL Gene

GeneHancer (GH) Regulatory Elements for SPOPL Gene

Promoters and enhancers for SPOPL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I138500 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.4 +1.6 1582 5.5 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF143 SP3 REST SPOPL LOC105373637 GC02M138488
GH02I137962 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9 -536.9 -536939 3.9 PKNOX1 CLOCK FOXA2 MLX ARID4B DMAP1 YY1 DEK PAF1 ZNF263 HNMT LOC105373637 SPOPL LOC105373636
GH02I138473 Enhancer 1 Ensembl ENCODE 12.4 -26.9 -26890 2.2 ELF3 FOXA2 MLX ARID4B ZSCAN9 RARA TCF12 IKZF2 CREM PPARG LOC105373637 SPOPL ENSG00000230569
GH02I138432 Enhancer 0.8 ENCODE 11 -67.6 -67639 2.3 FOXA2 PKNOX1 FEZF1 RAD21 TCF12 GATA2 EGR1 FOS RUNX3 EGR2 LOC105373637 SPOPL GC02M138423 LOC100129375
GH02I138536 Enhancer 0.7 ENCODE 11.8 +34.9 34890 1.2 PKNOX1 TAL1 EBF1 BMI1 RELA CC2D1A TCF12 ZNF316 CBFA2T2 ATF7 SPOPL LOC105373637 GC02M138488 ENSG00000241772
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPOPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPOPL gene promoter:

Genomic Locations for SPOPL Gene

Genomic Locations for SPOPL Gene
chr2:138,501,780-138,573,547
(GRCh38/hg38)
Size:
71,768 bases
Orientation:
Plus strand
chr2:139,259,350-139,331,117
(GRCh37/hg19)

Genomic View for SPOPL Gene

Genes around SPOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOPL Gene

Proteins for SPOPL Gene

  • Protein details for SPOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ16-SPOPL_HUMAN
    Recommended name:
    Speckle-type POZ protein-like
    Protein Accession:
    Q6IQ16

    Protein attributes for SPOPL Gene

    Size:
    392 amino acids
    Molecular mass:
    44647 Da
    Quaternary structure:
    • Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.

neXtProt entry for SPOPL Gene

Post-translational modifications for SPOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPOPL Gene

No data available for DME Specific Peptides for SPOPL Gene

Domains & Families for SPOPL Gene

Gene Families for SPOPL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPOPL Gene

Suggested Antigen Peptide Sequences for SPOPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ16

UniProtKB/Swiss-Prot:

SPOPL_HUMAN :
  • Belongs to the Tdpoz family.
Family:
  • Belongs to the Tdpoz family.
genes like me logo Genes that share domains with SPOPL: view

Function for SPOPL Gene

Molecular function for SPOPL Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.

Phenotypes From GWAS Catalog for SPOPL Gene

Gene Ontology (GO) - Molecular Function for SPOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with SPOPL: view
genes like me logo Genes that share phenotypes with SPOPL: view

Animal Models for SPOPL Gene

MGI Knock Outs for SPOPL:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPOPL Gene

Localization for SPOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOPL gene
Compartment Confidence
nucleus 4
cytosol 3
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0019005 SCF ubiquitin ligase complex IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 22632832
genes like me logo Genes that share ontologies with SPOPL: view

Pathways & Interactions for SPOPL Gene

genes like me logo Genes that share pathways with SPOPL: view

Pathways by source for SPOPL Gene

3 Reactome pathways for SPOPL Gene
1 KEGG pathway for SPOPL Gene

UniProtKB/Swiss-Prot Q6IQ16-SPOPL_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030162 regulation of proteolysis IBA --
GO:0031397 negative regulation of protein ubiquitination IMP 22632832
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 22632832
genes like me logo Genes that share ontologies with SPOPL: view

No data available for SIGNOR curated interactions for SPOPL Gene

Drugs & Compounds for SPOPL Gene

No Compound Related Data Available

Transcripts for SPOPL Gene

Unigene Clusters for SPOPL Gene

Speckle-type POZ protein-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOPL Gene

No ASD Table

Relevant External Links for SPOPL Gene

GeneLoc Exon Structure for
SPOPL
ECgene alternative splicing isoforms for
SPOPL

Expression for SPOPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOPL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPOPL Gene



NURSA nuclear receptor signaling pathways regulating expression of SPOPL Gene:

SPOPL

SOURCE GeneReport for Unigene cluster for SPOPL Gene:

Hs.333297

Evidence on tissue expression from TISSUES for SPOPL Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SPOPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOPL Gene

Orthologs for SPOPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPOPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPOPL 33 34
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia SPOPL 33 34
  • 96.17 (n)
cow
(Bos Taurus)
Mammalia SPOPL 33 34
  • 95.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPOPL 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spopl 33 16 34
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Spopl 33
  • 92.09 (n)
oppossum
(Monodelphis domestica)
Mammalia SPOPL 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOPL 33 34
  • 89.54 (n)
lizard
(Anolis carolinensis)
Reptilia SPOPL 34
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii spoplb 34
  • 89 (a)
OneToMany
spopla 33 34
  • 77.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta rdx 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea bath-43 34
  • 52 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BPM1 33
  • 44.63 (n)
rice
(Oryza sativa)
Liliopsida Os07g0655300 33
  • 44.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2083 34
  • 72 (a)
OneToMany
Species where no ortholog for SPOPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPOPL Gene

ENSEMBL:
Gene Tree for SPOPL (if available)
TreeFam:
Gene Tree for SPOPL (if available)

Paralogs for SPOPL Gene

Paralogs for SPOPL Gene

(2) SIMAP similar genes for SPOPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPOPL: view

Variants for SPOPL Gene

Sequence variations from dbSNP and Humsavar for SPOPL Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000048908 -- 138,505,146(+) T/C intron_variant
rs1000103575 -- 138,532,540(+) C/T intron_variant
rs1000147577 -- 138,526,549(+) A/G intron_variant
rs1000201616 -- 138,526,814(+) C/T intron_variant
rs1000225915 -- 138,555,231(+) GTT/ intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPOPL Gene

Variant ID Type Subtype PubMed ID
esv3380275 CNV insertion 20981092
nsv7329 OTHER inversion 18451855
nsv834390 CNV gain 17160897

Variation tolerance for SPOPL Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPOPL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOPL Gene

Disorders for SPOPL Gene

Additional Disease Information for SPOPL

No disorders were found for SPOPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOPL Gene

Publications for SPOPL Gene

  1. Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. (PMID: 22632832) Errington WJ … Privé GG (Structure (London, England : 1993) 2012) 2 3 4 58
  2. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. (PMID: 16651542) Kent D … Hooper JE (Development (Cambridge, England) 2006) 3 4 58
  3. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. (PMID: 16740475) Zhang Q … Jiang J (Developmental cell 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. (PMID: 27008177) Gschweitl M … Peter M (eLife 2016) 3 58

Products for SPOPL Gene

Sources for SPOPL Gene

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