Aliases for SPOPL Gene
External Ids for SPOPL Gene
Previous GeneCards Identifiers for SPOPL Gene
GeneCards Summary for SPOPL Gene
SPOPL (Speckle Type BTB/POZ Protein Like) is a Protein Coding gene. Diseases associated with SPOPL include Meier-Gorlin Syndrome 2 and Epilepsy, Idiopathic Generalized 9. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. An important paralog of this gene is SPOP.
UniProtKB/Swiss-Prot Summary for SPOPL Gene
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.