Aliases for SPON2 Gene

Aliases for SPON2 Gene

  • Spondin 2 2 3 5
  • DIL1 2 3 4
  • Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 1 3 4
  • Spondin 2, Extracellular Matrix Protein 2 3
  • Spondin-2 3 4
  • Mindin 2 4
  • DIL-1 3 4
  • M-Spondin 2
  • M-SPONDIN 3
  • MINDIN 3
  • SPON2 5

External Ids for SPON2 Gene

Previous GeneCards Identifiers for SPON2 Gene

  • GC04M001150

Summaries for SPON2 Gene

GeneCards Summary for SPON2 Gene

SPON2 (Spondin 2) is a Protein Coding gene. Diseases associated with SPON2 include Drug-Induced Lupus Erythematosus. Among its related pathways are Integrin Pathway and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include antigen binding and lipopolysaccharide binding. An important paralog of this gene is THSD7A.

UniProtKB/Swiss-Prot Summary for SPON2 Gene

  • Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Additional gene information for SPON2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPON2 Gene

Genomics for SPON2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPON2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPON2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPON2

Top Transcription factor binding sites by QIAGEN in the SPON2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • Nkx2-5

Genomic Locations for SPON2 Gene

Genomic Locations for SPON2 Gene
chr4:1,166,932-1,208,962
(GRCh38/hg38)
Size:
42,031 bases
Orientation:
Minus strand
chr4:1,160,720-1,202,750
(GRCh37/hg19)
Size:
42,031 bases
Orientation:
Minus strand

Genomic View for SPON2 Gene

Genes around SPON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON2 Gene

Proteins for SPON2 Gene

  • Protein details for SPON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUD6-SPON2_HUMAN
    Recommended name:
    Spondin-2
    Protein Accession:
    Q9BUD6
    Secondary Accessions:
    • D3DVN9
    • Q4W5N4
    • Q9ULW1

    Protein attributes for SPON2 Gene

    Size:
    331 amino acids
    Molecular mass:
    35846 Da
    Quaternary structure:
    • Monomer. Interacts with integrin.

    Three dimensional structures from OCA and Proteopedia for SPON2 Gene

neXtProt entry for SPON2 Gene

Post-translational modifications for SPON2 Gene

  • Glycosylation at Trp283
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPON2 Gene

Domains & Families for SPON2 Gene

Gene Families for SPON2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPON2 Gene

InterPro:
Blocks:
  • Thrombospondin, type I
  • Spondin, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SPON2 Gene

GenScript: Design optimal peptide antigens:
  • Spondin 2, extracellular matrix protein, isoform CRA_a (D3DVN9_HUMAN)
  • Mindin (SPON2_HUMAN)
genes like me logo Genes that share domains with SPON2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPON2 Gene

Function for SPON2 Gene

Molecular function for SPON2 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
GENATLAS Biochemistry:
spondin 2,differentially expressed in cancerous (high expression) and non cancerous lung cells (low expression)

Phenotypes From GWAS Catalog for SPON2 Gene

Gene Ontology (GO) - Molecular Function for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0003823 antigen binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPON2: view
genes like me logo Genes that share phenotypes with SPON2: view

Animal Models for SPON2 Gene

MGI Knock Outs for SPON2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPON2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPON2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPON2 Gene

Localization for SPON2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPON2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0031012 extracellular matrix IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SPON2: view

Pathways & Interactions for SPON2 Gene

PathCards logo

SuperPathways for SPON2 Gene

SuperPathway Contained pathways
1 Integrin Pathway
.67
.67
.56
.56
.50
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Phospholipase-C Pathway
.56
.56
4 O-glycosylation of TSR domain-containing proteins
5 Diseases of glycosylation
genes like me logo Genes that share pathways with SPON2: view

Pathways by source for SPON2 Gene

13 Qiagen pathways for SPON2 Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1

Gene Ontology (GO) - Biological Process for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002448 mast cell mediated immunity IEA --
GO:0007155 cell adhesion IBA 21873635
GO:0008228 opsonization IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with SPON2: view

No data available for SIGNOR curated interactions for SPON2 Gene

Drugs & Compounds for SPON2 Gene

No Compound Related Data Available

Transcripts for SPON2 Gene

mRNA/cDNA for SPON2 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPON2

Alternative Splicing Database (ASD) splice patterns (SP) for SPON2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SPON2 Gene

GeneLoc Exon Structure for
SPON2

Expression for SPON2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPON2 Gene

Protein differential expression in normal tissues from HIPED for SPON2 Gene

This gene is overexpressed in Amniocyte (59.1) and Synovial fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPON2 Gene



Protein tissue co-expression partners for SPON2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPON2

SOURCE GeneReport for Unigene cluster for SPON2 Gene:

Hs.635350

mRNA Expression by UniProt/SwissProt for SPON2 Gene:

Q9BUD6-SPON2_HUMAN
Tissue specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines.

Evidence on tissue expression from TISSUES for SPON2 Gene

  • Intestine(4.5)
  • Nervous system(3.8)
  • Skin(2.4)
  • Blood(2.3)
  • Liver(2.2)
  • Spleen(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with SPON2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPON2 Gene

Orthologs for SPON2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPON2 30 31
  • 99.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPON2 30 31
  • 82.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spon2 30
  • 80.87 (n)
Mouse
(Mus musculus)
Mammalia Spon2 30 17 31
  • 80.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC102155429 30
  • 79.78 (n)
SPON2 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SPON2 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPON2 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SPON2 30 31
  • 65.45 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPON2 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spon2 30
  • 62.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii spon2b 30 31
  • 63.25 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mspo 30 31 32
  • 53.8 (n)
OneToOne
CG17739 32
  • 34 (a)
CG30046 32
  • 32 (a)
CG30203 32
  • 32 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 13 (a)
ManyToMany
Species where no ortholog for SPON2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SPON2 Gene

ENSEMBL:
Gene Tree for SPON2 (if available)
TreeFam:
Gene Tree for SPON2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPON2: view image

Paralogs for SPON2 Gene

Paralogs for SPON2 Gene

(1) SIMAP similar genes for SPON2 Gene using alignment to 7 proteins:

  • SPON2_HUMAN
  • D6RA41_HUMAN
  • D6RB12_HUMAN
  • D6RBY3_HUMAN
  • D6REX2_HUMAN
  • D6RFY9_HUMAN
  • D6RIH5_HUMAN
genes like me logo Genes that share paralogs with SPON2: view

Variants for SPON2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPON2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
723005 Likely Benign: not provided 1,167,666(-) G/A INTRON_VARIANT
737377 Benign: not provided 1,167,607(-) T/C SYNONYMOUS_VARIANT
786030 Benign: not provided 1,167,660(-) G/A INTRON_VARIANT
787269 Benign: not provided 1,170,520(-) C/T SYNONYMOUS_VARIANT
rs11247975 - p.Glu122Ala

Additional dbSNP identifiers (rs#s) for SPON2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPON2 Gene

Variant ID Type Subtype PubMed ID
dgv636n27 CNV loss 19166990
dgv8890n54 CNV loss 21841781
dgv8891n54 CNV loss 21841781
esv2726766 CNV deletion 23290073
esv2726767 CNV deletion 23290073
esv2726768 CNV deletion 23290073
nsv1012892 CNV loss 25217958
nsv1074662 CNV deletion 25765185
nsv293242 CNV deletion 16902084
nsv475579 CNV novel sequence insertion 20440878
nsv508988 CNV insertion 20534489
nsv519106 CNV loss 19592680
nsv593278 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829835 CNV gain 17160897
nsv950331 CNV deletion 24416366

Variation tolerance for SPON2 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 71.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPON2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPON2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPON2 Gene

Disorders for SPON2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPON2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
drug-induced lupus erythematosus
  • dil
- elite association - COSMIC cancer census association via MalaCards
Search SPON2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SPON2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SPON2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPON2 Gene

Publications for SPON2 Gene

  1. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PMID: 10512675) Manda R … Yokota J (Genomics 1999) 2 3 4 23
  2. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. (PMID: 19153605) Li Y … Mariuzza RA (The EMBO journal 2009) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PMID: 18239089) Kong A … Stefansson K (Science (New York, N.Y.) 2008) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SPON2 Gene

  • Biorbyt antibodies for SPON2

Sources for SPON2 Gene