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SPON1 (Spondin 1) is a Protein Coding gene. Diseases associated with SPON1 include Peters-Plus Syndrome and Tremor, Hereditary Essential, 1. Among its related pathways are Integrin Pathway and NF-KappaB Family Pathway. An important paralog of this gene is THSD7A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
GO:0005515 | protein binding | IPI | 14983046 |
GO:0046872 | metal ion binding | IEA | -- |
GO:0050693 | LBD domain binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | HDA | 20551380 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0031012 | extracellular matrix | IBA | 21873635 |
GO:0062023 | colocalizes_with collagen-containing extracellular matrix | ISS | 22261194 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | 21873635 |
GO:0010954 | positive regulation of protein processing | IEA | -- |
GO:0032092 | positive regulation of protein binding | IEA | -- |
GO:1902430 | negative regulation of amyloid-beta formation | IEA | -- |
GO:1902993 | positive regulation of amyloid precursor protein catabolic process | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SPON1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | SPON1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | SPON1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Spon1 30 17 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Spon1 30 |
|
||
Chicken (Gallus gallus) |
Aves | SPON1 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spon1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | spon1-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | spon1a 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17739 30 32 |
|
||
fat-spondin 32 |
|
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|||
CG30046 32 |
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CG30203 32 |
|
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|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012307 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | F10E7.4 32 |
|
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv324e212 | CNV | loss | 25503493 |
esv1173943 | CNV | deletion | 17803354 |
esv1763444 | CNV | insertion | 17803354 |
esv2597158 | CNV | deletion | 19546169 |
esv2668036 | CNV | deletion | 23128226 |
esv29123 | CNV | loss | 19812545 |
esv3625418 | CNV | loss | 21293372 |
nsv1070011 | CNV | deletion | 25765185 |
nsv1070434 | CNV | deletion | 25765185 |
nsv478941 | CNV | novel sequence insertion | 20440878 |
nsv951310 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
peters-plus syndrome |
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|
tremor, hereditary essential, 1 |
|
|
tremor, hereditary essential, 2 |
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tremor, hereditary essential, 3 |
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|
charcot-marie-tooth disease, axonal, type 2b |
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|