Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPOCK2 Gene

Aliases for SPOCK2 Gene

  • SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2 2 3
  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2 2 3 5
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 2 3
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 3 4
  • Testican-2 3 3
  • KIAA0275 4
  • TICN2 4

External Ids for SPOCK2 Gene

Previous GeneCards Identifiers for SPOCK2 Gene

  • GC10M072922
  • GC10M073711
  • GC10M073163
  • GC10M073488
  • GC10M073818
  • GC10M067813

Summaries for SPOCK2 Gene

Entrez Gene Summary for SPOCK2 Gene

  • This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK2 Gene

SPOCK2 (SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPOCK3.

UniProtKB/Swiss-Prot for SPOCK2 Gene

  • May participate in diverse steps of neurogenesis. Binds calcium.

Gene Wiki entry for SPOCK2 Gene

Additional gene information for SPOCK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK2 Gene

Genomics for SPOCK2 Gene

GeneHancer (GH) Regulatory Elements for SPOCK2 Gene

Promoters and enhancers for SPOCK2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J072083 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 673.5 +2.1 2061 7.9 PKNOX1 ARID4B SIN3A DMAP1 RAD21 THRB ZNF48 ZNF335 EGR1 EGR2 SPOCK2 CHST3 ANAPC16 GC10P072062
GH10J072078 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +9.1 9139 2.6 BCOR HDGF ZNF768 PTBP1 USF1 ZNF140 ZMYM3 NFXL1 BMI1 ZIC2 SPOCK2 CDH23 ASCC1 GC10P072062
GH10J072068 Enhancer 0.9 dbSUPER 24.7 +19.4 19434 3.2 PKNOX1 MLX ARID4B DMAP1 ZNF48 ZNF143 ATF7 RXRA SP5 MXD4 SPOCK2 GC10P072062
GH10J071968 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.5 +113.0 112980 14.9 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B IRF4 YY1 ZNF766 ZNF143 CHST3 SPOCK2 PSAP NPM1P24 ENSG00000272988
GH10J072095 Enhancer 1.5 Ensembl ENCODE dbSUPER 13.9 -8.9 -8910 4.2 PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DNAJB12 SPOCK2 ENSG00000200294 ANAPC16 GC10P072228 ASCC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPOCK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPOCK2 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • Pax-4a
  • SRY
  • MyoD
  • RelA
  • FOXO1a
  • FOXO1

Genomic Locations for SPOCK2 Gene

Genomic Locations for SPOCK2 Gene
29,999 bases
Minus strand
29,999 bases
Minus strand

Genomic View for SPOCK2 Gene

Genes around SPOCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK2 Gene

Proteins for SPOCK2 Gene

  • Protein details for SPOCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • C9J767
    • Q6UW87

    Protein attributes for SPOCK2 Gene

    424 amino acids
    Molecular mass:
    46779 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13404.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK2 Gene


neXtProt entry for SPOCK2 Gene

Post-translational modifications for SPOCK2 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at posLast=388388, isoforms=383, and isoforms=225
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK2 Gene

No data available for DME Specific Peptides for SPOCK2 Gene

Domains & Families for SPOCK2 Gene

Gene Families for SPOCK2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SPOCK2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPOCK2: view

No data available for UniProtKB/Swiss-Prot for SPOCK2 Gene

Function for SPOCK2 Gene

Molecular function for SPOCK2 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Binds calcium.

Phenotypes From GWAS Catalog for SPOCK2 Gene

Gene Ontology (GO) - Molecular Function for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 10386950
GO:0005515 protein binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008191 metalloendopeptidase inhibitor activity TAS 12810672
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with SPOCK2: view
genes like me logo Genes that share phenotypes with SPOCK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPOCK2 Gene

Localization for SPOCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK2 gene
Compartment Confidence
extracellular 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPOCK2: view

Pathways & Interactions for SPOCK2 Gene

genes like me logo Genes that share pathways with SPOCK2: view

Pathways by source for SPOCK2 Gene

Interacting Proteins for SPOCK2 Gene

Gene Ontology (GO) - Biological Process for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007416 synapse assembly NAS 10386950
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0010951 negative regulation of endopeptidase activity TAS 12810672
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for SIGNOR curated interactions for SPOCK2 Gene

Drugs & Compounds for SPOCK2 Gene

(1) Drugs for SPOCK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SPOCK2: view

Transcripts for SPOCK2 Gene

Unigene Clusters for SPOCK2 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - -
SP4: -
SP5: - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP9: -

Relevant External Links for SPOCK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK2 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for SPOCK2 Gene

This gene is overexpressed in Testis (39.4) and Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPOCK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPOCK2 Gene:


SOURCE GeneReport for Unigene cluster for SPOCK2 Gene:


mRNA Expression by UniProt/SwissProt for SPOCK2 Gene:

Tissue specificity: Highly expressed in brain. Also found in lung and testis.

Evidence on tissue expression from TISSUES for SPOCK2 Gene

  • Nervous system(4.9)
  • Muscle(4.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with SPOCK2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK2 Gene

Orthologs for SPOCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCK2 34 33
  • 99.69 (n)
(Bos Taurus)
Mammalia SPOCK2 34 33
  • 93.45 (n)
(Canis familiaris)
Mammalia SPOCK2 34 33
  • 92.53 (n)
(Mus musculus)
Mammalia Spock2 16 34 33
  • 90.03 (n)
(Monodelphis domestica)
Mammalia SPOCK2 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCK2 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Spock2 33
  • 88.83 (n)
(Gallus gallus)
Aves SPOCK2 34
  • 67 (a)
(Anolis carolinensis)
Reptilia SPOCK2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spock2 33
  • 77.69 (n)
(Danio rerio)
Actinopterygii spock2 34 33
  • 70.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C54E4.2 34
  • 28 (a)
Species where no ortholog for SPOCK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK2 Gene

Gene Tree for SPOCK2 (if available)
Gene Tree for SPOCK2 (if available)
Evolutionary constrained regions (ECRs) for SPOCK2: view image

Paralogs for SPOCK2 Gene

Paralogs for SPOCK2 Gene

(5) SIMAP similar genes for SPOCK2 Gene using alignment to 3 proteins:

  • F5H283_HUMAN
  • L8E8K3_HUMAN
genes like me logo Genes that share paralogs with SPOCK2: view

Variants for SPOCK2 Gene

Sequence variations from dbSNP and Humsavar for SPOCK2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000111162 -- 72,082,172(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000159281 -- 72,086,594(-) A/G 3_prime_UTR_variant, intron_variant
rs1000199926 -- 72,085,320(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000274800 -- 72,085,630(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000533952 -- 72,087,083(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK2 Gene

Variant ID Type Subtype PubMed ID
nsv7204 OTHER inversion 18451855
nsv522541 CNV loss 19592680
nsv515889 CNV loss 19592680
nsv1144500 CNV deletion 24896259
esv3891857 CNV loss 25118596
esv3623790 CNV loss 21293372
esv3546492 CNV deletion 23714750
esv2738374 CNV deletion 23290073
esv2667322 CNV deletion 23128226
esv1328020 CNV deletion 17803354

Variation tolerance for SPOCK2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOCK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK2 Gene

Disorders for SPOCK2 Gene

Additional Disease Information for SPOCK2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPOCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOCK2 Gene

Publications for SPOCK2 Gene

  1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PMID: 10386950) Vannahme C … Maurer P (Journal of neurochemistry 1999) 2 3 4 58
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan RC … Wallaschofski H (Human molecular genetics 2011) 3 44 58
  3. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard SH … Kristensen VN (Genes, chromosomes & cancer 2008) 3 44 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58

Products for SPOCK2 Gene

Sources for SPOCK2 Gene

Loading form....