This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described f... See more...

Aliases for SPOCK2 Gene

Aliases for SPOCK2 Gene

  • SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2 2 3 5
  • Testican-2 2 3 4
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 2 3
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 3 4
  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2 2 3
  • KIAA0275 2 4
  • SPOCK2 5
  • TICN2 4

External Ids for SPOCK2 Gene

Previous GeneCards Identifiers for SPOCK2 Gene

  • GC10M072922
  • GC10M073711
  • GC10M073163
  • GC10M073488
  • GC10M073818
  • GC10M067813

Summaries for SPOCK2 Gene

Entrez Gene Summary for SPOCK2 Gene

  • This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK2 Gene

SPOCK2 (SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPOCK3.

UniProtKB/Swiss-Prot Summary for SPOCK2 Gene

Gene Wiki entry for SPOCK2 Gene

Additional gene information for SPOCK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPOCK2 Gene

Genomics for SPOCK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPOCK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J072083 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 623.2 +8.3 8342 7.9 HNRNPL GATAD2A SOX13 RBFOX2 PKNOX1 EZH2 ZNF600 YY1 ZNF341 CEBPA SPOCK2 lnc-SPOCK2-1-001 DNAJB12 CHST3 ANAPC16 lnc-SPOCK2-1-002 lnc-CHST3-1
GH10J072066 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 36.5 +26.6 26580 4.1 HNRNPL GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 ZNF692 RCOR2 JUND SPOCK2 lnc-CHST3-1 lnc-SPOCK2-1-001 CHST3
GH10J072078 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +15.4 15420 2.6 TEAD4 PRDM10 RFX1 KDM1A RCOR2 ZIC2 BRD9 SCRT2 ZNF140 SP1 SPOCK2 CDH23 ASCC1 lnc-SPOCK2-1-001 lnc-CHST3-1 CHST3
GH10J072056 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.9 +38.4 38413 1.8 HNRNPL GATAD2A TFE3 SOX13 RCOR2 ZNF7 RBFOX2 RXRB ZKSCAN8 TGIF2 SPOCK2 CDH23 ENSG00000272988 lnc-CHST3-1 CHST3
GH10J072044 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.6 +50.5 50495 1.2 HNRNPL GATAD2A TFE3 CTCF RCOR2 RBFOX2 IRF2 FOXK2 SOX13 TAF1 SPOCK2 CDH23 ENSG00000272988 HSALNG0078752 CHST3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPOCK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPOCK2

Top Transcription factor binding sites by QIAGEN in the SPOCK2 gene promoter:
  • FOXO1
  • FOXO1a
  • MyoD
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RelA
  • SRY

Genomic Locations for SPOCK2 Gene

Genomic Locations for SPOCK2 Gene
chr10:72,059,034-72,095,313
(GRCh38/hg38)
Size:
36,280 bases
Orientation:
Minus strand
chr10:73,818,792-73,848,790
(GRCh37/hg19)
Size:
29,999 bases
Orientation:
Minus strand

Genomic View for SPOCK2 Gene

Genes around SPOCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK2 Gene

Proteins for SPOCK2 Gene

  • Protein details for SPOCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92563-TICN2_HUMAN
    Recommended name:
    Testican-2
    Protein Accession:
    Q92563
    Secondary Accessions:
    • C9J767
    • Q6UW87

    Protein attributes for SPOCK2 Gene

    Size:
    424 amino acids
    Molecular mass:
    46779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13404.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPOCK2 Gene

Post-translational modifications for SPOCK2 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at Asn225, Ser383, and Ser388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK2 Gene

No data available for DME Specific Peptides for SPOCK2 Gene

Domains & Families for SPOCK2 Gene

Gene Families for SPOCK2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SPOCK2 Gene

InterPro:
Blocks:
  • Protease inhibitor, Kazal-type
  • Thyroglobulin type-1
ProtoNet:

Suggested Antigen Peptide Sequences for SPOCK2 Gene

GenScript: Design optimal peptide antigens:
  • SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (TICN2_HUMAN)
genes like me logo Genes that share domains with SPOCK2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPOCK2 Gene

Function for SPOCK2 Gene

Molecular function for SPOCK2 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Binds calcium.

Phenotypes From GWAS Catalog for SPOCK2 Gene

Gene Ontology (GO) - Molecular Function for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,IDA 10386950
GO:0005515 protein binding IEA --
GO:0005518 collagen binding IBA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008191 metalloendopeptidase inhibitor activity TAS 12810672
genes like me logo Genes that share ontologies with SPOCK2: view
genes like me logo Genes that share phenotypes with SPOCK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPOCK2 Gene

Localization for SPOCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK2 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0031012 extracellular matrix NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPOCK2 Gene

Pathways & Interactions for SPOCK2 Gene

PathCards logo

SuperPathways for SPOCK2 Gene

SuperPathway Contained pathways
1 Integrin Pathway
.67
.67
.56
.56
.50
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Phospholipase-C Pathway
.56
.56
genes like me logo Genes that share pathways with SPOCK2: view

Pathways by source for SPOCK2 Gene

13 Qiagen pathways for SPOCK2 Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1

Gene Ontology (GO) - Biological Process for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007416 synapse assembly NAS 10386950
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0010951 negative regulation of endopeptidase activity TAS 12810672
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
GO:0030198 extracellular matrix organization IEA,NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for SIGNOR curated interactions for SPOCK2 Gene

Drugs & Compounds for SPOCK2 Gene

(1) Drugs for SPOCK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with SPOCK2: view

Transcripts for SPOCK2 Gene

mRNA/cDNA for SPOCK2 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCK2

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -

Relevant External Links for SPOCK2 Gene

GeneLoc Exon Structure for
SPOCK2

Expression for SPOCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPOCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK2 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for SPOCK2 Gene

This gene is overexpressed in Testis (39.4) and Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPOCK2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPOCK2

SOURCE GeneReport for Unigene cluster for SPOCK2 Gene:

Hs.523009

mRNA Expression by UniProt/SwissProt for SPOCK2 Gene:

Q92563-TICN2_HUMAN
Tissue specificity: Highly expressed in brain. Also found in lung and testis.

Evidence on tissue expression from TISSUES for SPOCK2 Gene

  • Nervous system(4.9)
  • Muscle(4.3)
  • Lung(2.5)
  • Intestine(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SPOCK2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK2 Gene

Orthologs for SPOCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPOCK2 30 31
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SPOCK2 30 31
  • 93.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SPOCK2 30 31
  • 92.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spock2 30 17 31
  • 90.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK2 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SPOCK2 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spock2 30
  • 88.83 (n)
Chicken
(Gallus gallus)
Aves SPOCK2 31
  • 67 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SPOCK2 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia spock2 30
  • 77.69 (n)
Zebrafish
(Danio rerio)
Actinopterygii spock2 30 31
  • 70.54 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG13830 31
  • 19 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C54E4.2 31
  • 28 (a)
OneToMany
Species where no ortholog for SPOCK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SPOCK2 Gene

ENSEMBL:
Gene Tree for SPOCK2 (if available)
TreeFam:
Gene Tree for SPOCK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPOCK2: view image

Paralogs for SPOCK2 Gene

Paralogs for SPOCK2 Gene

(5) SIMAP similar genes for SPOCK2 Gene using alignment to 3 proteins:

  • TICN2_HUMAN
  • F5H283_HUMAN
  • L8E8K3_HUMAN
genes like me logo Genes that share paralogs with SPOCK2: view

Variants for SPOCK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPOCK2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
768372 Benign: not provided 72,062,886(-) C/T SYNONYMOUS_VARIANT
773516 Benign: not provided 72,063,097(-) C/T MISSENSE_VARIANT
780138 Benign: not provided 72,067,017(-) G/A SYNONYMOUS_VARIANT
780139 Benign: not provided 72,088,294(-) G/A MISSENSE_VARIANT
rs2306322 - p.Gly353Ser

Additional dbSNP identifiers (rs#s) for SPOCK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPOCK2 Gene

Variant ID Type Subtype PubMed ID
esv1328020 CNV deletion 17803354
esv2667322 CNV deletion 23128226
esv2738374 CNV deletion 23290073
esv3546492 CNV deletion 23714750
esv3623790 CNV loss 21293372
esv3891857 CNV loss 25118596
nsv1144500 CNV deletion 24896259
nsv515889 CNV loss 19592680
nsv522541 CNV loss 19592680
nsv7204 OTHER inversion 18451855

Variation tolerance for SPOCK2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOCK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPOCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK2 Gene

Disorders for SPOCK2 Gene

Additional Disease Information for SPOCK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for SPOCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOCK2 Gene

Publications for SPOCK2 Gene

  1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PMID: 10386950) Vannahme C … Maurer P (Journal of neurochemistry 1999) 2 3 4
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan RC … Wallaschofski H (Human molecular genetics 2011) 3 41
  3. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard SH … Kristensen VN (Genes, chromosomes & cancer 2008) 3 41
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SPOCK2 Gene

Sources for SPOCK2 Gene