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Aliases for SPOCK1 Gene

Aliases for SPOCK1 Gene

  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 1 2 3 5
  • SPOCK 3 4
  • TIC1 3 4
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 1 3
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2
  • Protein SPOCK 4
  • Testican-1 3
  • TICN1 4

External Ids for SPOCK1 Gene

Previous HGNC Symbols for SPOCK1 Gene

  • TIC1

Previous GeneCards Identifiers for SPOCK1 Gene

  • GC05M136339
  • GC05M131500
  • GC05M136310

Summaries for SPOCK1 Gene

Entrez Gene Summary for SPOCK1 Gene

  • This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPOCK1 Gene

SPOCK1 (SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 1) is a Protein Coding gene. Diseases associated with SPOCK1 include Chylothorax, Congenital and Coproporphyria, Hereditary. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SPOCK3.

UniProtKB/Swiss-Prot for SPOCK1 Gene

  • May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Gene Wiki entry for SPOCK1 Gene

Additional gene information for SPOCK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK1 Gene

Genomics for SPOCK1 Gene

GeneHancer (GH) Regulatory Elements for SPOCK1 Gene

Promoters and enhancers for SPOCK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I137498 Promoter/Enhancer 1.7 EPDnew Ensembl dbSUPER 557 +99.5 99478 1 CTCF MXI1 RB1 ZNF384 RAD21 GLIS2 POLR2A ZBTB48 ZNF143 SMC3 SPOCK1 GC05M137482 GC05P137461
GH05I138335 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -739.2 -739161 5 CLOCK ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 CDC25C FAM53C HNRNPA0 KDM3B RPL7P19 CDC23 REEP2 MATR3 NME5 SPOCK1
GH05I137620 Enhancer 0.9 Ensembl ENCODE 11.6 -23.9 -23851 2.7 GTF2F1 FOXA2 MAX EBF1 CEBPG YY1 FOS SOX5 RXRA CEBPB GC05M137622 PIR48538 SPOCK1 MIR874 KLHL3 NME5 EGR1 GC05M137619
GH05I137629 Enhancer 0.9 Ensembl ENCODE 11.1 -31.5 -31478 0.3 CTCF PKNOX1 SIN3A ZIC2 ZNF2 RAD21 RFX5 ZNF335 CC2D1A ZNF366 KLHL3 SPOCK1 RNU6-1148P REEP2 GC05M137619 MIR874
GH05I137618 Enhancer 0.8 Ensembl ENCODE 11.6 -20.8 -20813 1.7 GTF2F1 NFIB MNT CTBP1 GATA3 NFIC JUND CREB1 PRDM10 ZNF600 GC05M137622 PIR48538 SPOCK1 KLHL3 REEP2 LOC101928005 GC05M137619 GC05P137610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPOCK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPOCK1 gene promoter:

Genomic Locations for SPOCK1 Gene

Genomic Locations for SPOCK1 Gene
623,082 bases
Minus strand

Genomic View for SPOCK1 Gene

Genes around SPOCK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK1 Gene

Proteins for SPOCK1 Gene

  • Protein details for SPOCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KSW3
    • Q59EW0
    • Q8N630
    • Q9UCL8

    Protein attributes for SPOCK1 Gene

    439 amino acids
    Molecular mass:
    49124 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92938.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SPOCK1 Gene

Post-translational modifications for SPOCK1 Gene

  • O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at posLast=131131, isoforms=228, posLast=383383, and posLast=388388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK1 Gene

No data available for DME Specific Peptides for SPOCK1 Gene

Domains & Families for SPOCK1 Gene

Gene Families for SPOCK1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SPOCK1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPOCK1: view

No data available for UniProtKB/Swiss-Prot for SPOCK1 Gene

Function for SPOCK1 Gene

Molecular function for SPOCK1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Phenotypes From GWAS Catalog for SPOCK1 Gene

Gene Ontology (GO) - Molecular Function for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity NAS 14511383
GO:0004869 cysteine-type endopeptidase inhibitor activity IDA 14511383
GO:0005509 calcium ion binding IDA,IEA 9323035
GO:0008191 metalloendopeptidase inhibitor activity IDA 11751414
genes like me logo Genes that share ontologies with SPOCK1: view
genes like me logo Genes that share phenotypes with SPOCK1: view

Animal Models for SPOCK1 Gene

MGI Knock Outs for SPOCK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPOCK1 Gene

Localization for SPOCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 14511383
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density NAS 9181134
genes like me logo Genes that share ontologies with SPOCK1: view

Pathways & Interactions for SPOCK1 Gene

genes like me logo Genes that share pathways with SPOCK1: view

Pathways by source for SPOCK1 Gene

1 BioSystems pathway for SPOCK1 Gene

Gene Ontology (GO) - Biological Process for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8389704
GO:0001764 neuron migration ISS --
GO:0007155 cell adhesion NAS 8389704
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development NAS 9181134
genes like me logo Genes that share ontologies with SPOCK1: view

No data available for SIGNOR curated interactions for SPOCK1 Gene

Drugs & Compounds for SPOCK1 Gene

No Compound Related Data Available

Transcripts for SPOCK1 Gene

Unigene Clusters for SPOCK1 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK1 Gene

No ASD Table

Relevant External Links for SPOCK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOCK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for SPOCK1 Gene

This gene is overexpressed in Vitreous humor (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPOCK1 Gene

Protein tissue co-expression partners for SPOCK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPOCK1 Gene:


SOURCE GeneReport for Unigene cluster for SPOCK1 Gene:


Evidence on tissue expression from TISSUES for SPOCK1 Gene

  • Nervous system(5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SPOCK1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK1 Gene

Orthologs for SPOCK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCK1 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia SPOCK1 33 34
  • 92.06 (n)
(Bos Taurus)
Mammalia SPOCK1 33 34
  • 91.34 (n)
(Rattus norvegicus)
Mammalia Spock1 33
  • 90.13 (n)
(Mus musculus)
Mammalia Spock1 33 16 34
  • 89.75 (n)
(Ornithorhynchus anatinus)
Mammalia SPOCK1 34
  • 84 (a)
(Monodelphis domestica)
Mammalia SPOCK1 34
  • 81 (a)
(Gallus gallus)
Aves SPOCK1 33 34
  • 78.93 (n)
(Anolis carolinensis)
Reptilia SPOCK1 34
  • 82 (a)
(Danio rerio)
Actinopterygii SPOCK1 34
  • 68 (a)
LOC100331540 33
  • 66.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C54E4.2 34
  • 29 (a)
Species where no ortholog for SPOCK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPOCK1 Gene

Gene Tree for SPOCK1 (if available)
Gene Tree for SPOCK1 (if available)

Paralogs for SPOCK1 Gene

Paralogs for SPOCK1 Gene

(5) SIMAP similar genes for SPOCK1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPOCK1: view

Variants for SPOCK1 Gene

Sequence variations from dbSNP and Humsavar for SPOCK1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs587777311 uncertain-significance, not provided 137,140,688(-) T/A coding_sequence_variant, missense_variant
rs111393448 benign, not specified 137,498,449(-) T/C coding_sequence_variant, missense_variant
rs1000000681 -- 137,102,412(-) C/T intron_variant
rs1000001434 -- 137,008,292(-) AAA/A intron_variant
rs1000007305 -- 137,013,439(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK1 Gene

Variant ID Type Subtype PubMed ID
dgv1647e212 CNV loss 25503493
esv1973589 CNV deletion 18987734
esv2657276 CNV deletion 23128226
esv2661840 CNV deletion 23128226
esv2677084 CNV deletion 23128226
esv3306429 CNV mobile element insertion 20981092
esv3368747 CNV insertion 20981092
esv3443426 CNV insertion 20981092
esv3445385 CNV duplication 20981092
esv3570425 CNV loss 25503493
esv3606891 CNV loss 21293372
esv3606892 CNV gain 21293372
esv3606893 CNV gain 21293372
esv3606894 CNV gain 21293372
esv3606895 CNV loss 21293372
esv3606896 CNV loss 21293372
esv3606898 CNV loss 21293372
esv3606900 CNV loss 21293372
esv3606901 CNV loss 21293372
nsv1015658 CNV gain 25217958
nsv1029688 CNV loss 25217958
nsv1114732 CNV deletion 24896259
nsv328026 CNV insertion 16902084
nsv462459 CNV loss 19166990
nsv476258 CNV novel sequence insertion 20440878
nsv476867 CNV novel sequence insertion 20440878
nsv5020 CNV deletion 18451855
nsv515019 CNV gain 21397061
nsv599797 CNV loss 21841781
nsv830497 CNV loss 17160897
nsv830498 CNV gain 17160897

Variation tolerance for SPOCK1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOCK1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK1 Gene

Disorders for SPOCK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPOCK1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chylothorax, congenital
  • hydrothorax, congenital
coproporphyria, hereditary
  • hcp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPOCK1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPOCK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK1 Gene

Publications for SPOCK1 Gene

  1. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PMID: 19282985) Liu YZ … Deng HW (PLoS genetics 2009) 3 22 44 58
  2. Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PMID: 9545645) Charbonnier F … Alliel PM (Genomics 1998) 2 3 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for SPOCK1 Gene

Sources for SPOCK1 Gene

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