This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for SPOCD1 Gene

Aliases for SPOCD1 Gene

  • SPOC Domain Containing 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 146 2 3
  • SPOC Domain-Containing Protein 1 3 4
  • PPP1R146 3

External Ids for SPOCD1 Gene

Previous GeneCards Identifiers for SPOCD1 Gene

  • GC01M031926
  • GC01M032028
  • GC01M032256
  • GC01M030373

Summaries for SPOCD1 Gene

Entrez Gene Summary for SPOCD1 Gene

  • This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SPOCD1 Gene

SPOCD1 (SPOC Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is PHF3.

Additional gene information for SPOCD1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPOCD1 Gene

Genomics for SPOCD1 Gene

GeneHancer (GH) Regulatory Elements for SPOCD1 Gene

Promoters and enhancers for SPOCD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J031815 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 506.7 +0.0 16 1.3 ZNF217 CTCF USF1 GTF2E2 ZNF639 ZIC2 AFF1 TARDBP REST HES1 SPOCD1 SNRNP40 ZBTB8B KHDRBS1 ADGRB2 TSSK3 RBBP4 piR-32285-003
GH01J031814 Promoter/Enhancer 0.7 Ensembl dbSUPER 507.1 +1.0 950 0.2 ZIC2 GLIS1 SPOCD1 piR-32285-003
GH01J031825 Enhancer 1.1 ENCODE dbSUPER 8.9 -11.2 -11211 2.8 PHB2 ZBTB11 AFF1 TARDBP REST HES1 NR3C1 TOE1 MYC RUNX1 SPOCD1 piR-50443-011
GH01J031924 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.2 -119.8 -119782 22.1 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 TCF12 POLR2G KHDRBS1 SNRNP40 TXLNA RBBP4 ENSG00000229447 TSSK3 TMEM39B ZBTB8A PUM1 S100PBP
GH01J031711 Promoter/Enhancer 1.9 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 5.1 +102.2 102244 4.8 EP300 CTCF POLR2G NCOR1 PHF8 KDM6A GABPA AFF1 REST RFX1 ADGRB2 ENSG00000229167 TXLNA SNRNP40 ENSG00000229447 TSSK3 PEF1 ENSG00000235790 ENSG00000228634 EIF3I
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPOCD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPOCD1

Genomic Locations for SPOCD1 Gene

Genomic Locations for SPOCD1 Gene
25,630 bases
Minus strand
25,630 bases
Minus strand

Genomic View for SPOCD1 Gene

Genes around SPOCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCD1 Gene

Proteins for SPOCD1 Gene

  • Protein details for SPOCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPOC domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q24JU3
    • Q6PI90
    • Q8N869
    • Q8N8U0
    • Q8NBC6
    • Q96LN6

    Protein attributes for SPOCD1 Gene

    1216 amino acids
    Molecular mass:
    130027 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39870.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71652.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04981.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCD1 Gene


neXtProt entry for SPOCD1 Gene

Post-translational modifications for SPOCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPOCD1 Gene

Domains & Families for SPOCD1 Gene

Gene Families for SPOCD1 Gene

Protein Domains for SPOCD1 Gene

  • SPOC

Suggested Antigen Peptide Sequences for SPOCD1 Gene

GenScript: Design optimal peptide antigens:
  • SPOCD1 protein (Q05C62_HUMAN)
  • SPOCD1 protein (Q96I05_HUMAN)
  • SPOC domain-containing protein 1 (SPOC1_HUMAN)
genes like me logo Genes that share domains with SPOCD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPOCD1 Gene

Function for SPOCD1 Gene

Phenotypes From GWAS Catalog for SPOCD1 Gene

genes like me logo Genes that share phenotypes with SPOCD1: view

Animal Model Products

CRISPR Products

miRNA for SPOCD1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPOCD1 Gene

Localization for SPOCD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCD1 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPOCD1 Gene

Pathways & Interactions for SPOCD1 Gene

PathCards logo

SuperPathways for SPOCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPOCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with SPOCD1: view

No data available for Pathways by source and SIGNOR curated interactions for SPOCD1 Gene

Drugs & Compounds for SPOCD1 Gene

No Compound Related Data Available

Transcripts for SPOCD1 Gene

mRNA/cDNA for SPOCD1 Gene

14 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCD1

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - - -
SP10: - - - -
SP12: - - -
SP13: - -
SP15: -

ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP3: - - - -

Relevant External Links for SPOCD1 Gene

GeneLoc Exon Structure for

Expression for SPOCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPOCD1 Gene

mRNA differential expression in normal tissues according to GTEx for SPOCD1 Gene

This gene is overexpressed in Testis (x5.8) and Bladder (x4.1).

Protein differential expression in normal tissues from HIPED for SPOCD1 Gene

This gene is overexpressed in Pancreatic juice (31.4), Testis (29.1), and Adipocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPOCD1 Gene

Protein tissue co-expression partners for SPOCD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPOCD1

SOURCE GeneReport for Unigene cluster for SPOCD1 Gene:


Evidence on tissue expression from TISSUES for SPOCD1 Gene

  • Nervous system(4.4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with SPOCD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCD1 Gene

Orthologs for SPOCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCD1 31 30
  • 99 (n)
(Canis familiaris)
Mammalia SPOCD1 31 30
  • 79.37 (n)
(Bos Taurus)
Mammalia SPOCD1 31 30
  • 76.28 (n)
(Rattus norvegicus)
Mammalia Spocd1 30
  • 73.5 (n)
(Mus musculus)
Mammalia Spocd1 17 31 30
  • 68.4 (n)
(Monodelphis domestica)
Mammalia SPOCD1 31
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCD1 31
  • 21 (a)
(Anolis carolinensis)
Reptilia SPOCD1 31
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta pps 31
  • 7 (a)
Species where no ortholog for SPOCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPOCD1 Gene

Gene Tree for SPOCD1 (if available)
Gene Tree for SPOCD1 (if available)
Evolutionary constrained regions (ECRs) for SPOCD1: view image

Paralogs for SPOCD1 Gene

Paralogs for SPOCD1 Gene

(2) SIMAP similar genes for SPOCD1 Gene using alignment to 9 proteins:

  • H0YF46_HUMAN
  • Q05C62_HUMAN
  • Q96I05_HUMAN
genes like me logo Genes that share paralogs with SPOCD1: view

Variants for SPOCD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPOCD1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
717760 Likely Benign: not provided 31,814,589(-) G/C MISSENSE_VARIANT,INTRON_VARIANT
775531 Benign: not provided 31,814,602(-) G/C SYNONYMOUS_VARIANT,INTRON_VARIANT
786757 Benign: not provided 31,800,486(-) G/A SYNONYMOUS_VARIANT
rs1165078436 A breast cancer sample p.Arg671Trp
rs6664445 - p.Thr109Ala

Additional dbSNP identifiers (rs#s) for SPOCD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPOCD1 Gene

Variant ID Type Subtype PubMed ID
esv2517616 CNV insertion 19546169
esv2758930 CNV loss 17122850
esv3303073 CNV tandem duplication 20981092
esv3560349 CNV deletion 23714750
nsv1007390 CNV gain 25217958
nsv1007786 CNV gain 25217958
nsv1133129 CNV tandem duplication 24896259
nsv160616 CNV insertion 16902084
nsv822242 CNV loss 20364138
nsv950385 CNV deletion 24416366

Variation tolerance for SPOCD1 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.66; 91.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCD1 Gene

Disorders for SPOCD1 Gene

Additional Disease Information for SPOCD1

No disorders were found for SPOCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOCD1 Gene

Publications for SPOCD1 Gene

  1. SPOCD1 promotes cell proliferation and inhibits cell apoptosis in human osteosarcoma. (PMID: 29257309) Liang J … Li Z (Molecular medicine reports 2018) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 54
  4. Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer. (PMID: 28246015) Zhu M … Jin G (Gastroenterology 2017) 3 54
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M … da Cruz e Silva EF (Biochemical pharmacology 2011) 3 54

Products for SPOCD1 Gene

Sources for SPOCD1 Gene