Aliases for SPO11 Gene
- SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) 2
- SPO11, Meiotic Protein Covalently Bound To DSB (S. Cerevisiae)-Like 2
- SPO11 Meiotic Protein Covalently Bound To DSB-Like (S. Cerevisiae) 2
- SPO11 Meiotic Protein Covalently Bound To DSB Homolog 3
- SPO11 Meiotic Protein Covalently Bound To DSB 2
- EC 220.127.116.11 4
- SPO11 5
External Ids for SPO11 Gene
Previous GeneCards Identifiers for SPO11 Gene
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPO11 Gene
SPO11 (SPO11 Initiator Of Meiotic Double Stranded Breaks) is a Protein Coding gene. Diseases associated with SPO11 include Male Infertility and Fanconi Anemia, Complementation Group A. Among its related pathways are Meiosis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include hydrolase activity.
UniProtKB/Swiss-Prot Summary for SPO11 Gene
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.