Aliases for SPNS2 Gene
External Ids for SPNS2 Gene
Previous GeneCards Identifiers for SPNS2 Gene
The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]
GeneCards Summary for SPNS2 Gene
SPNS2 (Sphingolipid Transporter 2) is a Protein Coding gene. Diseases associated with SPNS2 include Deafness, Autosomal Recessive 115. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and sphingolipid transporter activity. An important paralog of this gene is SPNS1.
UniProtKB/Swiss-Prot Summary for SPNS2 Gene
Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.