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This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of... See more...
Aliases for SPN Gene
Aliases for SPN Gene
External Ids for SPN Gene
- HGNC: 11249
- Entrez Gene: 6693
- Ensembl: ENSG00000197471
- OMIM: 182160
- UniProtKB: P16150
Previous GeneCards Identifiers for SPN Gene
- GC16M028745
- GC16P029998
- GC16P029672
- GC16P029712
- GC16P029581
- GC16P027335
- GC16P029674
Summaries for SPN Gene
-
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]
GeneCards Summary for SPN Gene
SPN (Sialophorin) is a Protein Coding gene. Diseases associated with SPN include Wiskott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot Summary for SPN Gene
-
Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).
-
[CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival.
Additional gene information for SPN Gene
- HGNC(11249)
- Entrez Gene(6693)
- Ensembl(ENSG00000197471)
- OMIM(182160)
- UniProtKB(P16150)
- Open Targets Platform(ENSG00000197471)
- Monarch Initiative
- Search for SPN at DataMed
- Search for SPN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPN Gene
Genomics for SPN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SPN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPN
- Top Transcription factor binding sites by QIAGEN in the SPN gene promoter:
-
- AP-1
- p53
Genomic Locations for SPN Gene
Genomic Locations for SPN Gene
- chr16:29,662,950-29,670,876
- (GRCh38/hg38)
- Size:
- 7,927 bases
- Orientation:
- Plus strand
- chr16:29,674,300-29,682,187
- (GRCh37/hg19)
- Size:
- 7,888 bases
- Orientation:
- Plus strand
Genomic View for SPN Gene
Genes around SPN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
SPN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPN Gene
Proteins for SPN Gene
-
Protein details for SPN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16150-LEUK_HUMAN
- Recommended name:
- Leukosialin
- Protein Accession:
- P16150
- A8K9B1
Protein attributes for SPN Gene
- Size:
- 400 amino acids
- Molecular mass:
- 40322 Da
- Quaternary structure:
-
- Interacts with HIPK2 via the cytoplasmic domain. Interacts with SIGLEC1, RDX, EZR and MSN.
Protein Expression for SPN Gene
Post-translational modifications for SPN Gene
- Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
- Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes.
- Has a high content of sialic acid and O-linked carbohydrate structures.
- Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus.
- [CD43 cytoplasmic tail]: Sumoylated.
-
Glycosylation at Thr21, Thr22, Thr26, Thr28, Ser29, Ser35, Thr36, Ser37, Ser41, Ser42, Thr46, Thr47, Ser48, Thr50, Thr58, Thr69, Ser99, Ser103, Thr109, Thr113, Ser114, Thr136, Thr137, Thr173, Thr178, and Asn239
- NX_P16150 (NX_P16150-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- LEUK_HUMAN (340)
Other Protein References for SPN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD43 (PT1654) mouse mAb
- NSJ Bioreagents CD43 Antibody (Mouse Monoclonal)
- Novus Biologicals Antibodies for SPN
-
Abcam antibodies for SPN
- Invitrogen Antibodies for SPN (AFLGC-SPN)
- antibodies-online: Show 182 available CD43 Antibodies ranked by validation data
- Compare Top CD43 Antibodies
-
Recommended
- 286 WB Antibodies (anti-human)
- 115 IHC (p) Antibodies (anti-human)
- 85 FACS Antibodies (anti-human)
- 84 IHC (f) Antibodies (anti-human)
- 60 IHC Antibodies (anti-human)
- 9 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 41 FACS Antibodies (anti-mouse)
- 32 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 26 FACS Antibodies (anti-rat)
- 18 IHC (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 4 IHC (fro) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPN
- Sino Biological Antibodies for SPN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SPN
- Origene Custom Protein Services for SPN
- Sino Biological Cell Lysates for SPN
- Sino Biological Recombinant Proteins for SPN
- ProSpec Recombinant Proteins for SPN
-
Abcam proteins for SPN
Assay Products
- G Biosciences Immunotag™ Human SPN (Leukosialin) ELISA and Immunotag™ Leukosialin ELISA Kit
- RayBiotech Custom Human CD43/GALGP/Leukosialin ELISA
-
Signalway ELISA kits for SPN
No data available for DME Specific Peptides for SPN Gene
Domains & Families for SPN Gene
Gene Families for SPN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
Protein Domains for SPN Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPN Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ94351, Homo sapiens sialophorin (gpL115, leukosialin, CD43) (SPN), mRNA (A8K9B1_HUMAN)
- Sialophorin (LEUK_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPN Gene
Function for SPN Gene
Molecular function for SPN Gene
- UniProtKB/Swiss-Prot Function:
- Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).
- UniProtKB/Swiss-Prot Function:
- [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival.
- GENATLAS Biochemistry:
- sialophorin (gpl115,leukosialin) binding ezrin pradixin/moesin (ERM) proteins
Phenotypes From GWAS Catalog for SPN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | TAS,IEA | -- |
| GO:0030544 | Hsp70 protein binding | IPI | 20633027 |
| GO:0031072 | heat shock protein binding | IPI | 20633027 |
Phenotypes for SPN Gene
- MGI mutant phenotypes for SPN:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SPN:
Animal Models for SPN Gene
- MGI Knock Outs for SPN:
-
- Spn Spn<tm1Bam>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPN - Select products 50% OFF >
- * SPN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPN
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPN
miRNA for SPN Gene
- miRTarBase miRNAs that target SPN
-
- hsa-let-7e-5p (MIRT051630)
- hsa-let-7b-5p (MIRT052328)
- hsa-miR-4722-5p (MIRT488595)
- hsa-miR-4768-3p (MIRT488596)
- hsa-miR-5589-3p (MIRT534088)
- mmu-miR-1199-5p (MIRT593654)
- mmu-miR-3093-3p (MIRT593655)
- mmu-miR-3095-3p (MIRT593656)
- mmu-miR-3069-3p (MIRT593657)
- hsa-miR-574-5p (MIRT608335)
- hsa-miR-6867-5p (MIRT608336)
- hsa-miR-6818-5p (MIRT608337)
- hsa-miR-337-3p (MIRT629547)
- hsa-miR-6829-3p (MIRT629548)
- hsa-miR-6791-3p (MIRT629549)
- hsa-miR-4707-3p (MIRT629550)
- hsa-miR-519e-3p (MIRT629551)
- hsa-miR-515-3p (MIRT629552)
- hsa-miR-33b-3p (MIRT629553)
- hsa-miR-371a-3p (MIRT629554)
- hsa-miR-371b-3p (MIRT629555)
- hsa-miR-18a-3p (MIRT637361)
- hsa-miR-324-3p (MIRT637362)
- hsa-miR-1913 (MIRT637363)
- hsa-miR-6749-3p (MIRT653178)
- hsa-miR-7113-3p (MIRT653179)
- hsa-miR-3194-3p (MIRT653180)
- hsa-miR-510-3p (MIRT653181)
- hsa-miR-6881-3p (MIRT653182)
- hsa-miR-6780a-3p (MIRT653183)
- hsa-miR-7159-5p (MIRT653184)
- hsa-miR-877-3p (MIRT653185)
- hsa-miR-3065-5p (MIRT653186)
- hsa-miR-4666b (MIRT653187)
- hsa-miR-6750-3p (MIRT653188)
- hsa-miR-6805-3p (MIRT663279)
- hsa-miR-5691 (MIRT663280)
- hsa-miR-5001-3p (MIRT663281)
- hsa-miR-335-3p (MIRT710289)
- hsa-miR-5007-3p (MIRT710290)
- hsa-miR-4775 (MIRT710291)
- hsa-miR-664a-5p (MIRT710292)
- hsa-miR-4794 (MIRT710293)
- hsa-miR-4735-5p (MIRT710294)
- hsa-miR-1279 (MIRT710295)
- hsa-miR-6765-3p (MIRT710296)
- hsa-miR-590-3p (MIRT710297)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPN
- Browse OriGene Inhibitory RNA Products For SPN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPN
Clone Products
- Applied Biological Materials (abm): Clones for SPN - Select products 50% OFF >
- * SPN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPN
- Addgene plasmids for SPN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPN
Cell Line Products
-
Horizon Cell Lines for SPN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPN Gene
Localization for SPN Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPN Gene
- Membrane. Single-pass type I membrane protein. Cell projection, microvillus. Cell projection, uropodium. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250 UniProtKB:P13838, ECO:0000250 UniProtKB:P15702}.
- [CD43 cytoplasmic tail]: Nucleus. Nucleus, PML body.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 4 |
| golgi apparatus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001931 | uropod | ISS | -- |
| GO:0005615 | extracellular space | IDA | 10899905 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2023632 |
Pathways & Interactions for SPN Gene
Pathways by source for SPN Gene
3 Reactome pathways for SPN Gene
1 KEGG pathway for SPN Gene
2 R&D Systems pathways for SPN Gene
Interacting Proteins for SPN Gene
Selected Interacting proteins:
P16150-LEUK_HUMAN
ENSP00000353238
for SPN Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SPN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002296 | T-helper 1 cell lineage commitment | IDA | 18036228 |
| GO:0006935 | chemotaxis | TAS | 10753822 |
| GO:0006955 | immune response | TAS | 2023632 |
| GO:0006968 | cellular defense response | TAS | 1683685 |
| GO:0007162 | negative regulation of cell adhesion | TAS | 10753822 |
No data available for SIGNOR curated interactions for SPN Gene
Transcripts for SPN Gene
mRNA/cDNA for SPN Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360121 6894 nts (view in UCSC)
- ENST00000395389 1935 nts (view in UCSC)
- ENST00000436527 1197 nts (view in UCSC)
- ENST00000561857 2077 nts (view in UCSC)
- ENST00000563039 1853 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPN - Select products 50% OFF >
- * SPN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPN
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPN
- Browse OriGene Inhibitory RNA Products For SPN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPN
Clone Products
- Applied Biological Materials (abm): Clones for SPN - Select products 50% OFF >
- * SPN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPN
- Addgene plasmids for SPN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPN
Relevant External Links for SPN Gene
- GeneLoc Exon Structure for
- SPN
Expression for SPN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Pro B-Cells Hematopoietic Bone Marrow
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- B-cell Progenitor Cells Peripheral Blood
- Large Pre B-Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Double Positive Thymocytes Thymus
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for SPN Gene
This gene is overexpressed in Whole Blood (x10.3).
This gene is overexpressed in Pancreas (15.1), NK cells (10.4), Nasal epithelium (8.6), CD8 Tcells (8.0), and Neutrophil (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPN
SOURCE GeneReport for Unigene cluster for SPN Gene:
Hs.632188mRNA Expression by UniProt/SwissProt for SPN Gene:
P16150-LEUK_HUMAN
Tissue specificity:
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Evidence on tissue expression from TISSUES for SPN Gene
- Spleen(4.8)
- Blood(4.7)
- Kidney(4.4)
- Bone marrow(4.2)
- Lymph node(4.1)
- Intestine(3.7)
- Lung(3.2)
- Liver(2.7)
- Skin(2.3)
- Heart(2.2)
- Bone(2.2)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for SPN
-
OriGene qPCR primer pairs and template standards for SPN
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPN Gene
Orthologs for SPN Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SPN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SPN 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Spn 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Spn 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | SPN 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SPN 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SPN 31 |
|
OneToOne |
- Species where no ortholog for SPN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SPN Gene
- ENSEMBL:
- Gene Tree for SPN (if available)
- TreeFam:
- Gene Tree for SPN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPN: view image
Paralogs for SPN Gene
No data available for Paralogs for SPN Gene
Variants for SPN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPN Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710083 | Benign: not provided | 29,664,376(+) | C/T | SYNONYMOUS_VARIANT | |
| 717407 | Benign: not provided | 29,663,793(+) | C/T | MISSENSE_VARIANT | |
| 733825 | Benign: not provided | 29,664,565(+) | G/A | SYNONYMOUS_VARIANT | |
| 777002 | Benign: not provided | 29,664,403(+) | C/T | SYNONYMOUS_VARIANT | |
| 778501 | Benign: not provided | 29,664,525(+) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv34n68 | CNV | loss | 17160897 |
| esv2758641 | CNV | gain | 17122850 |
| nsv1063706 | CNV | gain | 25217958 |
| nsv833183 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.15;
51.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPN Gene
Disorders for SPN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wiskott-aldrich syndrome |
|
|
| adenoid basal cell carcinoma |
|
|
| aleukemic monocytic leukemia cutis |
|
|
| richter's syndrome |
|
|
| multicentric papillary thyroid carcinoma |
|
|
Search SPN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SPN Gene
Publications for SPN Gene
- The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. (PMID: 18586676) Mambole A … Halbwachs-Mecarelli L (The Journal of biological chemistry 2008) 3 4 23
- Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). (PMID: 1731338) Schmid K … Walsh MT (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 23
- Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. (PMID: 2241892) Shelley CS … Whitehead AS (The Biochemical journal 1990) 3 4 23
- Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. (PMID: 2521952) Pallant A … Frelinger JG (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4
- Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (PMID: 2784859) Shelley CS … Whitehead AS (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4
ExternalLinks
Products for SPN Gene
- View all 23 R&D Systems SPN (CD43) Products
- View all R&D Systems SPN (CD43) Proteins and Enzymes
- View all 20 R&D Systems SPN (CD43) Primary Antibodies
- View all R&D Systems SPN (CD43) Proteome Profiler Antibody Arrays
- View all R&D Systems SPN (CD43) cDNA Clones
- Learn more about R&D Systems custom SPN antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SPN
- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for SPN
- Origene Custom Protein Services for SPN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPN
- Browse OriGene Inhibitory RNA Products For SPN
- OriGene qPCR primer pairs for SPN
- OriGene qPCR primer pairs and template standards for SPN
- OriGene CRISPR knockouts for SPN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPN
- Sino Biological Human cDNA Clone for SPN
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- VectorBuilder Custom and pre-made DNA vectors for SPN (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder CRISPR vectors for SPN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SPN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SPN
- Addgene plasmids for SPN
- antibodies-online: Show 182 available CD43 Antibodies ranked by validation data
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- 41 FACS Antibodies (anti-mouse)
- 32 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 26 FACS Antibodies (anti-rat)
- 18 IHC (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 4 IHC (fro) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- antibodies-online: Show 12 available CD43 Elisa Kits ranked by validation data
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- antibodies-online: Show 15 available CD43 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SPN
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for SPN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPN
Sources for SPN Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
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- (33) SGD
- (34) FlyBase
- (35) WormBase
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- (38) dbSNP
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- (44) Atlas
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (64) Proteopedia
- (65) MOPED
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (77) ESI-BIO
- (78) RefSeq
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- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
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- (89) antibodies-online
- (90) CYP
- (91) NONCODE
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (103) SIGNOR
- (104) diseasecard
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- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
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- (152) DiseaseEnhancer
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- (154) Biorbyt
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- (163) LncBase
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- (165) LNCipedia
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB