Aliases for SPIRE2 Gene

Aliases for SPIRE2 Gene

  • Spire Type Actin Nucleation Factor 2 2 3 5
  • Spire Family Actin Nucleation Factor 2 2 3
  • Protein Spire Homolog 2 3 4
  • Spir-2 3 4
  • Spire-Type Actin Nucleation Factor 2 2
  • Spire Actin Nucleation Factor 2 3
  • Spire Homolog 2 (Drosophila) 2
  • Spire Homolog 2 3
  • KIAA1832 4
  • SPIR2 4

External Ids for SPIRE2 Gene

Previous GeneCards Identifiers for SPIRE2 Gene

  • GC16P089639
  • GC16P088421
  • GC16P089894
  • GC16P075589

Summaries for SPIRE2 Gene

GeneCards Summary for SPIRE2 Gene

SPIRE2 (Spire Type Actin Nucleation Factor 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.

UniProtKB/Swiss-Prot Summary for SPIRE2 Gene

  • Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).

Additional gene information for SPIRE2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPIRE2 Gene

Genomics for SPIRE2 Gene

GeneHancer (GH) Regulatory Elements for SPIRE2 Gene

Promoters and enhancers for SPIRE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPIRE2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPIRE2 gene promoter:
  • AP-2gamma
  • COMP1
  • Elk-1
  • GATA-3
  • LCR-F1
  • Olf-1
  • POU2F1
  • POU2F1a

Genomic Locations for SPIRE2 Gene

Genomic Locations for SPIRE2 Gene
chr16:89,817,477-89,871,319
(GRCh38/hg38)
Size:
53,843 bases
Orientation:
Plus strand
chr16:89,884,587-89,937,727
(GRCh37/hg19)
Size:
53,141 bases
Orientation:
Plus strand

Genomic View for SPIRE2 Gene

Genes around SPIRE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIRE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIRE2 Gene

Proteins for SPIRE2 Gene

  • Protein details for SPIRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL2-SPIR2_HUMAN
    Recommended name:
    Protein spire homolog 2
    Protein Accession:
    Q8WWL2
    Secondary Accessions:
    • A4QPB1
    • Q2TA98
    • Q6P433
    • Q8ND47
    • Q96JJ5

    Protein attributes for SPIRE2 Gene

    Size:
    714 amino acids
    Molecular mass:
    79671 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD19439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIRE2 Gene

    Alternative splice isoforms for SPIRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIRE2 Gene

Post-translational modifications for SPIRE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIRE2 Gene

No data available for DME Specific Peptides for SPIRE2 Gene

Domains & Families for SPIRE2 Gene

Gene Families for SPIRE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPIRE2 Gene

Suggested Antigen Peptide Sequences for SPIRE2 Gene

GenScript: Design optimal peptide antigens:
  • Protein spire homolog 2 (SPIR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWL2

UniProtKB/Swiss-Prot:

SPIR2_HUMAN :
  • Binds to actin monomers via the WH2 domain.
  • Belongs to the spire family.
Domain:
  • Binds to actin monomers via the WH2 domain.
  • The Spir-box targets binding to intracellular membrane structures.
Family:
  • Belongs to the spire family.
genes like me logo Genes that share domains with SPIRE2: view

Function for SPIRE2 Gene

Molecular function for SPIRE2 Gene

UniProtKB/Swiss-Prot Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).

Phenotypes From GWAS Catalog for SPIRE2 Gene

Gene Ontology (GO) - Molecular Function for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with SPIRE2: view

Phenotypes for SPIRE2 Gene

genes like me logo Genes that share phenotypes with SPIRE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPIRE2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIRE2 Gene

Localization for SPIRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIRE2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250 UniProtKB:Q8K1S6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIRE2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

Pathways & Interactions for SPIRE2 Gene

PathCards logo

SuperPathways for SPIRE2 Gene

SuperPathway Contained pathways
1 TGF-Beta Pathway
.51
genes like me logo Genes that share pathways with SPIRE2: view

Pathways by source for SPIRE2 Gene

1 Qiagen pathway for SPIRE2 Gene
  • JNK Pathway

Gene Ontology (GO) - Biological Process for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport ISS,IEA --
GO:0030036 actin cytoskeleton organization IEA,IMP 21620703
GO:0036089 cleavage furrow formation IEA,ISS --
GO:0040038 polar body extrusion after meiotic divisions IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

No data available for SIGNOR curated interactions for SPIRE2 Gene

Drugs & Compounds for SPIRE2 Gene

(1) Drugs for SPIRE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LATRUNCULIN B Experimental Pharma Target 0
genes like me logo Genes that share compounds with SPIRE2: view

Transcripts for SPIRE2 Gene

mRNA/cDNA for SPIRE2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPIRE2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIRE2 Gene

No ASD Table

Relevant External Links for SPIRE2 Gene

GeneLoc Exon Structure for
SPIRE2
ECgene alternative splicing isoforms for
SPIRE2

Expression for SPIRE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIRE2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3), Pituitary (x4.3), Colon - Transverse (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SPIRE2 Gene

This gene is overexpressed in Heart (47.7) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIRE2 Gene



Protein tissue co-expression partners for SPIRE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIRE2 Gene:

SPIRE2

SOURCE GeneReport for Unigene cluster for SPIRE2 Gene:

Hs.461786

Evidence on tissue expression from TISSUES for SPIRE2 Gene

  • Nervous system(4.2)
  • Skin(4)
genes like me logo Genes that share expression patterns with SPIRE2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIRE2 Gene

Orthologs for SPIRE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPIRE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIRE2 33 32
  • 99.01 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPIRE2 33 32
  • 84.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Spire2 17 33 32
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Spire2 32
  • 83.82 (n)
cow
(Bos Taurus)
Mammalia SPIRE2 33
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIRE2 33
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPIRE2 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPIRE2 33 32
  • 74.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPIRE2 33
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spire2 32
  • 62.75 (n)
Str.1771 32
zebrafish
(Danio rerio)
Actinopterygii spire2 33 32
  • 63.61 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008101 32
  • 60.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta spir 33
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8252 33
  • 26 (a)
OneToMany
Species where no ortholog for SPIRE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIRE2 Gene

ENSEMBL:
Gene Tree for SPIRE2 (if available)
TreeFam:
Gene Tree for SPIRE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPIRE2: view image

Paralogs for SPIRE2 Gene

Paralogs for SPIRE2 Gene

(1) SIMAP similar genes for SPIRE2 Gene using alignment to 3 proteins:

  • SPIR2_HUMAN
  • H3BV39_HUMAN
  • H3BV74_HUMAN
genes like me logo Genes that share paralogs with SPIRE2: view

Variants for SPIRE2 Gene

Sequence variations from dbSNP and Humsavar for SPIRE2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000091326 -- 89,856,659(+) C/T intron_variant
rs1000135075 -- 89,836,116(+) A/G intron_variant
rs1000181534 -- 89,859,602(+) A/G intron_variant
rs1000187229 -- 89,857,725(+) C/A intron_variant
rs1000331789 -- 89,845,077(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPIRE2 Gene

Variant ID Type Subtype PubMed ID
dgv1389n106 CNV deletion 24896259
dgv5324n54 CNV loss 21841781
dgv5325n54 CNV loss 21841781
dgv5326n54 CNV loss 21841781
dgv5327n54 CNV loss 21841781
dgv5328n54 CNV loss 21841781
dgv5329n54 CNV loss 21841781
dgv5330n54 CNV loss 21841781
dgv5331n54 CNV loss 21841781
dgv5332n54 CNV loss 21841781
dgv5333n54 CNV gain+loss 21841781
dgv5334n54 CNV loss 21841781
dgv5335n54 CNV loss 21841781
dgv63e180 CNV loss 20482838
esv1005255 CNV deletion 20482838
esv1071043 CNV insertion 17803354
esv23219 CNV gain+loss 19812545
esv2501942 CNV insertion 19546169
esv2657578 CNV deletion 23128226
esv2663404 CNV deletion 23128226
esv2668309 CNV deletion 23128226
esv2758671 CNV loss 17122850
esv2762221 CNV gain+loss 21179565
esv29066 CNV loss 19812545
esv3180457 CNV deletion 24192839
esv32652 CNV loss 17666407
esv3385098 CNV duplication 20981092
esv3553914 CNV deletion 23714750
esv3553915 CNV deletion 23714750
esv3639600 CNV loss 21293372
esv3639601 CNV loss 21293372
esv993879 CNV deletion 20482838
nsv1059577 CNV loss 25217958
nsv1070370 CNV deletion 25765185
nsv1071317 CNV deletion 25765185
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv457624 CNV loss 19166990
nsv482951 CNV loss 15286789
nsv573743 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv573770 CNV loss 21841781
nsv573791 CNV loss 21841781
nsv573798 CNV gain+loss 21841781
nsv573799 CNV gain 21841781
nsv573810 CNV loss 21841781
nsv833331 CNV gain+loss 17160897
nsv9478 CNV loss 18304495

Variation tolerance for SPIRE2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPIRE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIRE2 Gene

Disorders for SPIRE2 Gene

Additional Disease Information for SPIRE2

No disorders were found for SPIRE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIRE2 Gene

Publications for SPIRE2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 56
  2. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. (PMID: 26287480) Belin BJ … Mullins RD (eLife 2015) 3 4 56
  3. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PMID: 21620703) Pfender S … Schuh M (Current biology : CB 2011) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56

Products for SPIRE2 Gene

Sources for SPIRE2 Gene