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Aliases for SPIRE2 Gene
Aliases for SPIRE2 Gene
External Ids for SPIRE2 Gene
- HGNC: 30623
- Entrez Gene: 84501
- Ensembl: ENSG00000204991
- OMIM: 609217
- UniProtKB: Q8WWL2
Previous GeneCards Identifiers for SPIRE2 Gene
- GC16P089639
- GC16P088421
- GC16P089894
- GC16P075589
Summaries for SPIRE2 Gene
GeneCards Summary for SPIRE2 Gene
SPIRE2 (Spire Type Actin Nucleation Factor 2) is a Protein Coding gene. Diseases associated with SPIRE2 include Osteogenesis Imperfecta, Type Ii and Osteogenesis Imperfecta, Type I. Among its related pathways are TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.
UniProtKB/Swiss-Prot Summary for SPIRE2 Gene
-
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).
Additional gene information for SPIRE2 Gene
- HGNC(30623)
- Entrez Gene(84501)
- Ensembl(ENSG00000204991)
- OMIM(609217)
- UniProtKB(Q8WWL2)
- Open Targets Platform(ENSG00000204991)
- Search for SPIRE2 at DataMed
- Search for SPIRE2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPIRE2 Gene
Genomics for SPIRE2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SPIRE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SPIRE2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPIRE2
- Top Transcription factor binding sites by QIAGEN in the SPIRE2 gene promoter:
-
- AP-2gamma
- COMP1
- Elk-1
- GATA-3
- LCR-F1
- Olf-1
- POU2F1
- POU2F1a
Genomic Locations for SPIRE2 Gene
Genomic Locations for SPIRE2 Gene
- chr16:89,818,179-89,871,319
- (GRCh38/hg38)
- Size:
- 53,141 bases
- Orientation:
- Plus strand
- chr16:89,884,587-89,937,727
- (GRCh37/hg19)
- Size:
- 53,141 bases
- Orientation:
- Plus strand
Genomic View for SPIRE2 Gene
Genes around SPIRE2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by HGNC
- 16q24.3 by Entrez Gene
- 16q24.3 by Ensembl
SPIRE2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPIRE2 Gene
Proteins for SPIRE2 Gene
-
Protein details for SPIRE2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWL2-SPIR2_HUMAN
- Recommended name:
- Protein spire homolog 2
- Protein Accession:
- Q8WWL2
- A4QPB1
- Q2TA98
- Q6P433
- Q8ND47
- Q96JJ5
Protein attributes for SPIRE2 Gene
- Size:
- 714 amino acids
- Molecular mass:
- 79671 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB47461.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD19439.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for SPIRE2 Gene
Post-translational modifications for SPIRE2 Gene
Other Protein References for SPIRE2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SPIRE2
- Novus Biologicals Antibodies for SPIRE2
- Invitrogen Antibodies for SPIRE2 (AFLGC-SPIRE2)
-
Biorbyt antibodies for SPIRE2
-
Boster Bio Antibodies for SPIRE2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPIRE2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIRE2
- Origene Custom Protein Services for SPIRE2
- antibodies-online: Show 3 available SPIRE2 Proteins ranked by validation data
- Compare Top SPIRE2 Proteins
-
Quality Products:
-
Signalway Proteins for SPIRE2
No data available for DME Specific Peptides for SPIRE2 Gene
Domains & Families for SPIRE2 Gene
Gene Families for SPIRE2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SPIRE2 Gene
Suggested Antigen Peptide Sequences for SPIRE2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein spire homolog 2 (SPIR2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WWL2UniProtKB/Swiss-Prot:
SPIR2_HUMAN :- Binds to actin monomers via the WH2 domain.
- Belongs to the spire family.
- Domain:
-
- Binds to actin monomers via the WH2 domain.
- The Spir-box targets binding to intracellular membrane structures.
- Family:
-
- Belongs to the spire family.
Function for SPIRE2 Gene
Molecular function for SPIRE2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).
Phenotypes From GWAS Catalog for SPIRE2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
Phenotypes for SPIRE2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPIRE2 - Select products 50% OFF >
- * SPIRE2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPIRE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPIRE2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIRE2
miRNA for SPIRE2 Gene
- miRTarBase miRNAs that target SPIRE2
-
- hsa-miR-6778-3p (MIRT613829)
- hsa-miR-3137 (MIRT613830)
- hsa-miR-1976 (MIRT613831)
- hsa-miR-3653-5p (MIRT613832)
- hsa-miR-6747-3p (MIRT613833)
- hsa-miR-6727-3p (MIRT613834)
- hsa-miR-4722-3p (MIRT613835)
- hsa-miR-331-3p (MIRT613836)
- hsa-miR-6810-3p (MIRT613837)
- hsa-miR-6801-3p (MIRT613838)
- hsa-miR-4279 (MIRT618716)
- hsa-miR-6749-3p (MIRT631444)
- hsa-miR-4469 (MIRT631445)
- hsa-miR-5193 (MIRT631446)
- hsa-miR-3934-5p (MIRT631447)
- hsa-miR-764 (MIRT631448)
- hsa-miR-125a-3p (MIRT631449)
- hsa-miR-498 (MIRT662689)
- hsa-miR-378a-5p (MIRT662690)
- hsa-miR-6821-3p (MIRT662691)
- hsa-miR-6790-3p (MIRT662692)
- hsa-miR-372-5p (MIRT662693)
- hsa-miR-371a-5p (MIRT662694)
- hsa-miR-616-5p (MIRT662695)
- hsa-miR-373-5p (MIRT662696)
- hsa-miR-371b-5p (MIRT662697)
- hsa-miR-4667-3p (MIRT662698)
- hsa-miR-1470 (MIRT662699)
- hsa-miR-4532 (MIRT671582)
- hsa-miR-1247-3p (MIRT671583)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPIRE2
- Browse OriGene Inhibitory RNA Products For SPIRE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPIRE2
Clone Products
- Applied Biological Materials (abm): Clones for SPIRE2 - Select products 50% OFF >
- * SPIRE2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPIRE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPIRE2
Cell Line Products
-
Horizon Cell Lines for SPIRE2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIRE2 Gene
Localization for SPIRE2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPIRE2 Gene
- Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250 UniProtKB:Q8K1S6}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Intermediate filaments (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for SPIRE2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TGF-Beta Pathway |
JNK Pathway
.51
|
|
Pathways by source for SPIRE2 Gene
1 Qiagen pathway for SPIRE2 Gene
- JNK Pathway
Interacting Proteins for SPIRE2 Gene
Selected Interacting proteins:
Q8WWL2-SPIR2_HUMAN
ENSP00000367494
for SPIRE2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SPIRE2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015031 | protein transport | IEA | -- |
| GO:0016192 | vesicle-mediated transport | IEA,ISS | -- |
| GO:0030036 | actin cytoskeleton organization | IEA,IMP | 21620703 |
| GO:0036089 | cleavage furrow formation | IEA,ISS | -- |
| GO:0040038 | polar body extrusion after meiotic divisions | IEA,ISS | -- |
No data available for SIGNOR curated interactions for SPIRE2 Gene
Drugs & Compounds for SPIRE2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Latrunculin B | Experimental | Pharma | Target | 0 |
Transcripts for SPIRE2 Gene
mRNA/cDNA for SPIRE2 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378247 3268 nts (view in UCSC)
- ENST00000393062 2172 nts (view in UCSC)
- ENST00000561883 672 nts (view in UCSC)
- ENST00000562029 2215 nts (view in UCSC)
- ENST00000563972 1823 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SPIRE2 - Select products 50% OFF >
- * SPIRE2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SPIRE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPIRE2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPIRE2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPIRE2
- Browse OriGene Inhibitory RNA Products For SPIRE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPIRE2
Clone Products
- Applied Biological Materials (abm): Clones for SPIRE2 - Select products 50% OFF >
- * SPIRE2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SPIRE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPIRE2
Relevant External Links for SPIRE2 Gene
- GeneLoc Exon Structure for
- SPIRE2
Expression for SPIRE2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SPIRE2 Gene
This gene is overexpressed in Brain - Cerebellum (x4.3), Pituitary (x4.3), Colon - Transverse (x4.2), and Brain - Cerebellar Hemisphere (x4.1).
This gene is overexpressed in Heart (47.7) and Placenta (13.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIRE2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPIRE2
SOURCE GeneReport for Unigene cluster for SPIRE2 Gene:
Hs.461786Evidence on tissue expression from TISSUES for SPIRE2 Gene
- Nervous system(4.4)
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs for SPIRE2
-
OriGene qPCR primer pairs and template standards for SPIRE2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIRE2 Gene
Orthologs for SPIRE2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SPIRE2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SPIRE2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Spire2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Spire2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | SPIRE2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SPIRE2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SPIRE2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SPIRE2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SPIRE2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | spire2 30 |
|
||
| Str.1771 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | spire2 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008101 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | spir 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8252 31 |
|
OneToMany |
- Species where no ortholog for SPIRE2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SPIRE2 Gene
- ENSEMBL:
- Gene Tree for SPIRE2 (if available)
- TreeFam:
- Gene Tree for SPIRE2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SPIRE2: view image
Paralogs for SPIRE2 Gene
Variants for SPIRE2 Gene
Residual Variation Intolerance Score:
58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.58;
72.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPIRE2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPIRE2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPIRE2 Gene
Disorders for SPIRE2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| osteogenesis imperfecta, type ii |
|
|
| osteogenesis imperfecta, type i |
|
|
| autoimmune vasculitis |
|
|
| fanconi anemia, complementation group a |
|
|
Search SPIRE2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPIRE2
No data available for UniProtKB/Swiss-Prot and Genatlas for SPIRE2 Gene
Publications for SPIRE2 Gene
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
- DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. (PMID: 26287480) Belin BJ … Mullins RD (eLife 2015) 3 4
- Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PMID: 21620703) Pfender S … Schuh M (Current biology : CB 2011) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
ExternalLinks
Products for SPIRE2 Gene
- Custom Antibody ServicesOriGene Antibodies for SPIRE2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SPIRE2
- Origene Custom Protein Services for SPIRE2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SPIRE2
- Browse OriGene Inhibitory RNA Products For SPIRE2
- OriGene qPCR primer pairs for SPIRE2
- OriGene qPCR primer pairs and template standards for SPIRE2
- OriGene CRISPR knockouts for SPIRE2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SPIRE2
- Sino Biological Human cDNA Clone for SPIRE2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SPIRE2
- Novus Biologicals proteins and lysates for SPIRE2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for SPIRE2 (AFLGC-SPIRE2)
- VectorBuilder Custom and pre-made DNA vectors for SPIRE2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SPIRE2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SPIRE2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SPIRE2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SPIRE2
- antibodies-online: Show 12 available SPIRE2 Antibodies ranked by validation data
- Compare Top SPIRE2 Antibodies
- antibodies-online: Search results for available SPIRE2 related products ranked by validation data
- antibodies-online: Show 3 available SPIRE2 Proteins ranked by validation data
- Compare Top SPIRE2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SPIRE2
- Search Santa Cruz Biotechnology (SCBT) for SPIRE2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPIRE2
- Horizon Cell Lines for SPIRE2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SPIRE2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SPIRE2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SPIRE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPIRE2
- Boster Bio Antibodies for SPIRE2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for SPIRE2
- Signalway Proteins for SPIRE2
Sources for SPIRE2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
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