Aliases for SPIRE2 Gene
External Ids for SPIRE2 Gene
Previous GeneCards Identifiers for SPIRE2 Gene
GeneCards Summary for SPIRE2 Gene
SPIRE2 (Spire Type Actin Nucleation Factor 2) is a Protein Coding gene. Diseases associated with SPIRE2 include Osteogenesis Imperfecta, Type Ii and Osteogenesis Imperfecta, Type I. Among its related pathways are TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.
UniProtKB/Swiss-Prot Summary for SPIRE2 Gene
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).