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SPINT4 (Serine Peptidase Inhibitor, Kunitz Type 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is TFPI2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20J045722 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -17 | 0.1 | SPINT4 WFDC10B WFDC3 | ||
GH20J045695 | Enhancer | 0.2 | Ensembl | 11 | -26.7 | -26746 | 0.8 | piR-46002-350 piR-52368-085 WFDC3 SPINT4 WFDC13 WFDC10B WFDC11 | ||
GH20J045725 | Enhancer | 0.8 | ENCODE | 0.7 | +2.9 | 2908 | 0.1 | GATAD2A TFE3 NFKBIZ RCOR2 RXRB IRF2 SP1 CEBPA SOX13 RFX3 | HNRNPA1P3 SPINT5P WFDC13 SPINT4 piR-41306-164 WFDC3 | |
GH20J045777 | Promoter/Enhancer | 1.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.2 | +59.3 | 59254 | 7.6 | CREB1 ATF7 PRDM10 ZNF629 ZNF692 TARDBP ZHX2 JUND FOXA1 ZIC2 | lnc-TNNC2-2 WFDC10B WFDC3 DNTTIP1 WFDC13 RF00619-020 RNU6ATAC38P piR-57133-369 lnc-WFDC3-1 SPINT4 | |
GH20J045770 | Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.2 | +50.4 | 50444 | 4 | GATAD2A CTCF TFE3 JUND FOXA1 PRDM1 ZNF143 POLR2A RXRB REST | WFDC3 WFDC13 SPINT5P HNRNPA1P3 UBE2C SNX21 TNNC2 EPPIN EPPIN-WFDC6 HSPD1P21 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
GO:0030414 | peptidase inhibitor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010466 | negative regulation of peptidase activity | IEA | -- |
GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SPINT4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SPINT4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Spint4 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SPINT4 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16990631 | - | p.Ala30Glu | |||
rs6017667 | - | p.Gly73Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1247e212 | CNV | loss | 25503493 |
dgv4320n100 | CNV | loss | 25217958 |
dgv4321n100 | CNV | loss | 25217958 |
dgv7590n54 | CNV | loss | 21841781 |
dgv7591n54 | CNV | loss | 21841781 |
dgv7592n54 | CNV | loss | 21841781 |
esv23805 | CNV | gain | 19812545 |
esv24579 | CNV | loss | 19812545 |
esv2678145 | CNV | deletion | 23128226 |
esv2751915 | CNV | loss | 17911159 |
esv2751916 | CNV | loss | 17911159 |
esv2763671 | CNV | loss | 21179565 |
esv33602 | CNV | loss | 17666407 |
esv3557119 | CNV | deletion | 23714750 |
esv3645939 | CNV | loss | 21293372 |
nsv458986 | CNV | loss | 19166990 |
nsv514940 | CNV | gain | 21397061 |
nsv586081 | CNV | loss | 21841781 |
nsv586115 | CNV | loss | 21841781 |
nsv586116 | CNV | loss | 21841781 |
nsv586121 | CNV | loss | 21841781 |
No disorders were found for SPINT4 Gene.