Aliases for SPINT4 Gene
Aliases for SPINT4 Gene
External Ids for SPINT4 Gene
- HGNC: 16130
- Entrez Gene: 391253
- Ensembl: ENSG00000149651
- UniProtKB: Q6UDR6
Previous HGNC Symbols for SPINT4 Gene
- C20orf137
Previous GeneCards Identifiers for SPINT4 Gene
- GC00U901027
- GC20P043785
- GC20P044350
- GC20P041092
Summaries for SPINT4 Gene
GeneCards Summary for SPINT4 Gene
SPINT4 (Serine Peptidase Inhibitor, Kunitz Type 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity.
Additional gene information for SPINT4 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT4 Gene
Genomics for SPINT4 Gene
GeneHancer (GH) Regulatory Elements for SPINT4 Gene
Promoters and enhancers for SPINT4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20I045722 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -19 | 0.1 | SPINT4 MIR3617 | ||
| GH20I045725 | Enhancer | 0.8 | ENCODE | 0.8 | +2.9 | 2906 | 0.1 | FOXA2 ARID4B RARA HSF1 CREM THAP11 MIXL1 HMG20B RXRA CEBPB | SPINT5P HNRNPA1P3 WFDC10B WFDC13 SPINT4 | |
| GH20I045726 | Enhancer | 0.3 | ENCODE | 0.4 | +5.0 | 5009 | 0.7 | POLR2A | WFDC3 WFDC10B WFDC13 RNU6ATAC38P SPINT4 HNRNPA1P3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPINT4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SPINT4 Gene
Genomic Locations for SPINT4 Gene
- chr20:45,722,349-45,725,830
- (GRCh38/hg38)
- Size:
- 3,482 bases
- Orientation:
- Plus strand
- chr20:44,350,988-44,354,469
- (GRCh37/hg19)
Genomic View for SPINT4 Gene
Genes around SPINT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
SPINT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPINT4 Gene
Proteins for SPINT4 Gene
-
Protein details for SPINT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UDR6-SPIT4_HUMAN
- Recommended name:
- Kunitz-type protease inhibitor 4
- Protein Accession:
- Q6UDR6
- Q9BQN3
Protein attributes for SPINT4 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11421 Da
- Quaternary structure:
- No Data Available
Protein Expression for SPINT4 Gene
Post-translational modifications for SPINT4 Gene
Other Protein References for SPINT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
-
OriGene Purified Proteins for SPINT4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPINT4
- Origene Custom Protein Services for SPINT4
- Search GeneTex for Proteins for SPINT4
Assay Products
No data available for DME Specific Peptides for SPINT4 Gene
Domains & Families for SPINT4 Gene
Gene Families for SPINT4 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for SPINT4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPINT4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SPINT4 Gene
Function for SPINT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for SPINT4 Gene
- GenomeRNAi human phenotypes for SPINT4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPINT4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPINT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPINT4 gene
- Search ViGene Biosciences for SPINT4
CRISPR Products
-
OriGene CRISPR knockouts for SPINT4
- genomics-online: gRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- Applied Biological Materials CRISPR for SPINT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPINT4
- GenScript: Design CRISPR guide RNA sequences for SPINT4
miRNA for SPINT4 Gene
- miRTarBase miRNAs that target SPINT4
miRNA Products
- Search ViGene Biosciences for SPINT4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPINT4
- Browse OriGene Inhibitory RNA Products For SPINT4
- genomics-online: shRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPINT4 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPINT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPINT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SPINT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPINT4
-
ViGene Biosciences adenoviral particle packaged cDNA for SPINT4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPINT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPINT4 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINT4 Gene
Localization for SPINT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPINT4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPINT4 Gene
Pathways & Interactions for SPINT4 Gene
No Data Available
Interacting Proteins for SPINT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPINT4 Gene
Transcripts for SPINT4 Gene
mRNA/cDNA for SPINT4 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPINT4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPINT4
- genomics-online: gRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- Applied Biological Materials CRISPR for SPINT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPINT4
- GenScript: Design CRISPR guide RNA sequences for SPINT4
miRNA Products
- Search ViGene Biosciences for SPINT4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPINT4
- Browse OriGene Inhibitory RNA Products For SPINT4
- genomics-online: shRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPINT4 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SPINT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPINT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SPINT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SPINT4 Gene
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPINT4 Gene
NURSA nuclear receptor signaling pathways regulating expression of SPINT4 Gene:
SPINT4SOURCE GeneReport for Unigene cluster for SPINT4 Gene:
Hs.677891Evidence on tissue expression from TISSUES for SPINT4 Gene
- Eye(2.9)
Primer Products
-
OriGene qPCR primer pairs for SPINT4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPINT4 Gene
Orthologs for SPINT4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPINT4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SPINT4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Spint4 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SPINT4 34 |
|
OneToOne |
- Species where no ortholog for SPINT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SPINT4 Gene
(6) SIMAP similar genes for SPINT4 Gene using alignment to 1 proteins:
No data available for Paralogs for SPINT4 Gene
Variants for SPINT4 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000264752 | -- | 45,724,182(+) | A/G | intron_variant | |
| rs1001296615 | -- | 45,724,887(+) | G/A | intron_variant | |
| rs1001702050 | -- | 45,722,125(+) | C/G/T | upstream_transcript_variant | |
| rs1001767368 | -- | 45,724,560(+) | A/T | intron_variant | |
| rs1004040410 | -- | 45,720,918(+) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1247e212 | CNV | loss | 25503493 |
| dgv4320n100 | CNV | loss | 25217958 |
| dgv4321n100 | CNV | loss | 25217958 |
| dgv7590n54 | CNV | loss | 21841781 |
| dgv7591n54 | CNV | loss | 21841781 |
| dgv7592n54 | CNV | loss | 21841781 |
| esv23805 | CNV | gain | 19812545 |
| esv24579 | CNV | loss | 19812545 |
| esv2678145 | CNV | deletion | 23128226 |
| esv2751915 | CNV | loss | 17911159 |
| esv2751916 | CNV | loss | 17911159 |
| esv2763671 | CNV | loss | 21179565 |
| esv33602 | CNV | loss | 17666407 |
| esv3557119 | CNV | deletion | 23714750 |
| esv3645939 | CNV | loss | 21293372 |
| nsv458986 | CNV | loss | 19166990 |
| nsv514940 | CNV | gain | 21397061 |
| nsv586081 | CNV | loss | 21841781 |
| nsv586115 | CNV | loss | 21841781 |
| nsv586116 | CNV | loss | 21841781 |
| nsv586121 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.35;
7.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPINT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPINT4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINT4 Gene
Disorders for SPINT4 Gene
Additional Disease Information for SPINT4
No disorders were found for SPINT4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINT4 Gene
Publications for SPINT4 Gene
- Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products. (PMID: 21988899) Clauss A … Lundwall Š(BMC biochemistry 2011) 2 3 58
- Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. (PMID: 21536719) Ferreira Z … Seixas S (Molecular biology and evolution 2011) 3 58
- Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li JY … Zhang YL (DNA research : an international journal for rapid publication of reports on genes and genomes 2008) 3 58
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 4 58
Products for SPINT4 Gene
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- Custom Assay Services
- OriGene Purified Proteins for SPINT4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPINT4
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- OriGene qPCR primer pairs for SPINT4
- OriGene CRISPR knockouts for SPINT4
- OriGene ORF clones in human for SPINT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for SPINT4
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Tissue Microarrays
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- Browse Lysates
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPINT4
- VectorBuilder custom plasmid, inducible vectors for SPINT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPINT4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available SPINT4 related products ranked by validation data
- antibodies-online: Search results for available SPINT4 related products ranked by validation data
- antibodies-online: Search results for available SPINT4 related products ranked by validation data
- Search GeneTex for Antibodies for SPINT4
- Search GeneTex for Proteins for SPINT4
- ViGene Biosciences adenoviral particle packaged cDNA for SPINT4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPINT4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPINT4 gene
- Search ViGene Biosciences for SPINT4
- Horizon Cell Lines for SPINT4
- genomics-online: cdna clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- orf clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- genomics-online: gRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- genomics-online: primer clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
- genomics-online: shRNA clones - Search results for 76 available SPINT4 gene related products
- Overview of 76 available SPINT4 gene related products
Sources for SPINT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems