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Aliases for SPINT3 Gene

Aliases for SPINT3 Gene

  • Serine Peptidase Inhibitor, Kunitz Type 3 2 3 5
  • Serine Protease Inhibitor, Kunitz Type, 3 2 3
  • HKIB9 3 4
  • Kunitz-Type Protease Inhibitor 3 3

External Ids for SPINT3 Gene

Previous GeneCards Identifiers for SPINT3 Gene

  • GC20M043869
  • GC20M043829
  • GC20M044779
  • GC20M044826
  • GC20M043574
  • GC20U900207
  • GC20M044141
  • GC20M040882

Summaries for SPINT3 Gene

GeneCards Summary for SPINT3 Gene

SPINT3 (Serine Peptidase Inhibitor, Kunitz Type 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is TFPI2.

Additional gene information for SPINT3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT3 Gene

Genomics for SPINT3 Gene

GeneHancer (GH) Regulatory Elements for SPINT3 Gene

Promoters and enhancers for SPINT3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045515 Promoter 0.6 EPDnew 550.8 0.0 -18 0.1 REST SPINT3 ENSG00000232135
GH20I045765 Enhancer 0.3 ENCODE 10 -250.8 -250779 2.6 POLR2A WFDC3 WFDC13 DNTTIP1 HNRNPA1P3 EPPIN EPPIN-WFDC6 ENSG00000232135 HSPD1P21 WFDC6 SPINT3
GH20I045507 Enhancer 0.9 FANTOM5 ENCODE 0.4 +8.4 8411 0.3 MEIS2 MAX EBF1 BATF IRF4 ZBTB40 FOSL1 GATA3 NFATC1 ATF7 ZNF335 SPINT3 RPL5P2
GH20I045510 Enhancer 0.4 FANTOM5 0.8 +5.0 4975 0.3 CEBPB CEBPG ZNF335 SYS1 SPINT3 RPL5P2
GH20I045508 Enhancer 0.6 ENCODE 0.4 +7.3 7310 0.5 ZNF197 CEBPG EP300 PPARG RARA NR2C1 FOS RXRB NR2C2 ENSG00000232135 SPINT3 RPL5P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPINT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPINT3 gene promoter:

Genomic Locations for SPINT3 Gene

Genomic Locations for SPINT3 Gene
3,164 bases
Minus strand

Genomic View for SPINT3 Gene

Genes around SPINT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINT3 Gene

Proteins for SPINT3 Gene

  • Protein details for SPINT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kunitz-type protease inhibitor 3
    Protein Accession:
    Secondary Accessions:
    • A6NCQ6
    • Q6UDR8
    • Q96KK2

    Protein attributes for SPINT3 Gene

    89 amino acids
    Molecular mass:
    10252 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINT3 Gene

Post-translational modifications for SPINT3 Gene

No Post-translational modifications

Other Protein References for SPINT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINT3 Gene

Domains & Families for SPINT3 Gene

Gene Families for SPINT3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SPINT3 Gene

Suggested Antigen Peptide Sequences for SPINT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPINT3: view

No data available for UniProtKB/Swiss-Prot for SPINT3 Gene

Function for SPINT3 Gene

Gene Ontology (GO) - Molecular Function for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPINT3: view

Phenotypes for SPINT3 Gene

GenomeRNAi human phenotypes for SPINT3:
genes like me logo Genes that share phenotypes with SPINT3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINT3 Gene

Localization for SPINT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINT3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPINT3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPINT3 Gene

Pathways & Interactions for SPINT3 Gene

SuperPathways for SPINT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINT3: view

No data available for Pathways by source and SIGNOR curated interactions for SPINT3 Gene

Drugs & Compounds for SPINT3 Gene

No Compound Related Data Available

Transcripts for SPINT3 Gene

mRNA/cDNA for SPINT3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINT3 Gene

Serine peptidase inhibitor, Kunitz type, 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINT3 Gene

No ASD Table

Relevant External Links for SPINT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPINT3 Gene

mRNA differential expression in normal tissues according to GTEx for SPINT3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.8) and Skin - Sun Exposed (Lower leg) (x18.4).

NURSA nuclear receptor signaling pathways regulating expression of SPINT3 Gene:


SOURCE GeneReport for Unigene cluster for SPINT3 Gene:


Evidence on tissue expression from TISSUES for SPINT3 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SPINT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPINT3 Gene

Orthologs for SPINT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPINT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINT3 33 34
  • 98.5 (n)
(Mus musculus)
Mammalia Spint3 34
  • 28 (a)
(Bos Taurus)
Mammalia -- 34
  • 24 (a)
(Canis familiaris)
Mammalia ELP 34
  • 23 (a)
(Monodelphis domestica)
Mammalia ELP 34
  • 12 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Anolis carolinensis)
Reptilia SPINT3 34
  • 3 (a)
(Danio rerio)
Actinopterygii wu:fb59d01 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea F22E12.1 34
  • 3 (a)
mec-9 34
  • 3 (a)
ZK287.4 34
  • 2 (a)
mec-1 34
  • 1 (a)
Species where no ortholog for SPINT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPINT3 Gene

Gene Tree for SPINT3 (if available)
Gene Tree for SPINT3 (if available)

Paralogs for SPINT3 Gene

Paralogs for SPINT3 Gene

(14) SIMAP similar genes for SPINT3 Gene using alignment to 1 proteins: Pseudogenes for SPINT3 Gene

genes like me logo Genes that share paralogs with SPINT3: view

Variants for SPINT3 Gene

Sequence variations from dbSNP and Humsavar for SPINT3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000320754 -- 45,516,317(-) C/A upstream_transcript_variant
rs1000395980 -- 45,516,566(-) G/A upstream_transcript_variant
rs1000660171 -- 45,514,886(-) A/T intron_variant
rs1002207839 -- 45,515,315(-) G/C intron_variant
rs1003292956 -- 45,517,004(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPINT3 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for SPINT3 Gene

Gene Damage Index Score: 3.98; 60.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPINT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINT3 Gene

Disorders for SPINT3 Gene

Additional Disease Information for SPINT3

No disorders were found for SPINT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINT3 Gene

Publications for SPINT3 Gene

  1. Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products. (PMID: 21988899) Clauss A … Lundwall Å (BMC biochemistry 2011) 2 3 58
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein JL … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 44 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis. (PMID: 17589793) Lundwall A (Asian journal of andrology 2007) 3 58
  5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N … Van Dorsselaer A (Proteomics 2003) 3 58

Products for SPINT3 Gene

Sources for SPINT3 Gene

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