Aliases for SPINT2 Gene
External Ids for SPINT2 Gene
Previous GeneCards Identifiers for SPINT2 Gene
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for SPINT2 Gene
SPINT2 (Serine Peptidase Inhibitor, Kunitz Type 2) is a Protein Coding gene. Diseases associated with SPINT2 include Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies and Diarrhea 8, Secretory Sodium, Congenital. Among its related pathways are Signaling by MST1 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is SPINT1.
UniProtKB/Swiss-Prot for SPINT2 Gene
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.