Aliases for SPINK9 Gene
External Ids for SPINK9 Gene
Previous GeneCards Identifiers for SPINK9 Gene
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
GeneCards Summary for SPINK9 Gene
SPINK9 (Serine Peptidase Inhibitor Kazal Type 9) is a Protein Coding gene. Diseases associated with SPINK9 include Pompholyx and Netherton Syndrome. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINK7.
UniProtKB/Swiss-Prot Summary for SPINK9 Gene
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.