Aliases for SPINK13 Gene

Aliases for SPINK13 Gene

  • Serine Peptidase Inhibitor Kazal Type 13 2 3 5
  • SPINK5L3 2 3 4
  • Hepatitis B Virus DNA Polymerase Transactivated Serine Protease Inhibitor 3 4
  • Serine Protease Inhibitor Kazal-Type 5-Like 3 3 4
  • Serine Protease Inhibitor Kazal-Type 13 3 4
  • HBVDNAPTP1 3 4
  • HESPINTOR 2 3
  • LiESP6 2 3
  • Hepatitis B Virus DNA Polymerase Transactivated Human Serine Protease Inhibitor 3
  • Hepatitis B Virus (HBV) DNA Polymerase Transactivated Protein 1 3
  • Serine Peptidase Inhibitor, Kazal Type 13 (Putative) 3
  • Serine Peptidase Inhibitor Kazal Type 13 (Putative) 2
  • MGC149260 2
  • Hespintor 4
  • SPINK13 5

External Ids for SPINK13 Gene

Previous GeneCards Identifiers for SPINK13 Gene

  • GC05P147648
  • GC05P142795

Summaries for SPINK13 Gene

GeneCards Summary for SPINK13 Gene

SPINK13 (Serine Peptidase Inhibitor Kazal Type 13) is a Protein Coding gene. Diseases associated with SPINK13 include Plasminogen Deficiency, Type I. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINK14.

UniProtKB/Swiss-Prot Summary for SPINK13 Gene

  • May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity).

Additional gene information for SPINK13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPINK13 Gene

Genomics for SPINK13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPINK13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J148267 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 600.7 +0.3 290 1.5 ZNF341 NR3C1 CEBPB FOXA2 JUN JUND POLR2A ZNF189 FOSL2 FOS SPINK13 piR-60885-121 SPINK7 ENSG00000247199 LOC102546294
GH05J148266 Enhancer 0.2 FANTOM5 600.7 -1.6 -1568 0.1 SPINK13 piR-47086-250 MARCOL ENSG00000247199 LOC102546294
GH05J148223 Enhancer 0.8 FANTOM5 ENCODE 11.8 -43.8 -43774 1.2 CEBPB JUN GTF2F1 JUND EP300 POLR2A PRDM1 RFX5 STAT3 TBP SPINK6 SPINK13 SPINK7 MARCOL NONHSAG041876.2 piR-47086-250 ENSG00000247199
GH05J148205 Enhancer 0.8 FANTOM5 Ensembl 9.7 -61.0 -60979 5.6 SP1 YY1 GABPA ZBTB33 JUND FOXA1 HNF4A RXRA MAFK MAX SPINK6 SPINK7 SPINK14 SPINK9 SPINK13 FBXO38 ENSG00000272411 SPINK5 HMGN1P16 MARCOL
GH05J148237 Enhancer 0.7 ENCODE 11.5 -30.2 -30166 1.5 CREB1 SCRT2 ZBTB10 BRCA1 ZEB1 CEBPB OSR2 RCOR1 JUND MAX SPINK6 SPINK13 SPINK7 SPINK9 piR-47086-250 MARCOL NONHSAG041876.2 ENSG00000247199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPINK13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPINK13

Genomic Locations for SPINK13 Gene

Genomic Locations for SPINK13 Gene
chr5:148,268,180-148,286,255
(GRCh38/hg38)
Size:
18,076 bases
Orientation:
Plus strand
chr5:147,647,743-147,665,817
(GRCh37/hg19)
Size:
18,075 bases
Orientation:
Plus strand

Genomic View for SPINK13 Gene

Genes around SPINK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINK13 Gene

Proteins for SPINK13 Gene

  • Protein details for SPINK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1W4C9-ISK13_HUMAN
    Recommended name:
    Serine protease inhibitor Kazal-type 13
    Protein Accession:
    Q1W4C9
    Secondary Accessions:
    • A1A4Y2

    Protein attributes for SPINK13 Gene

    Size:
    94 amino acids
    Molecular mass:
    11051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPINK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPINK13 Gene

Post-translational modifications for SPINK13 Gene

  • Glycosylation at Asn55
  • Modification sites at PhosphoSitePlus

Other Protein References for SPINK13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINK13 Gene

Domains & Families for SPINK13 Gene

Gene Families for SPINK13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPINK13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPINK13 Gene

GenScript: Design optimal peptide antigens:
  • Serine protease inhibitor Kazal-type 5-like 3 (ISK13_HUMAN)
genes like me logo Genes that share domains with SPINK13: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPINK13 Gene

Function for SPINK13 Gene

Molecular function for SPINK13 Gene

UniProtKB/Swiss-Prot Function:
May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity).

Gene Ontology (GO) - Molecular Function for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPINK13: view
genes like me logo Genes that share phenotypes with SPINK13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPINK13

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPINK13 Gene

Localization for SPINK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINK13 Gene

Secreted. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPINK13 gene
Compartment Confidence
extracellular 4
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINK13: view

Pathways & Interactions for SPINK13 Gene

PathCards logo

SuperPathways for SPINK13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:1902225 negative regulation of acrosome reaction ISS --
genes like me logo Genes that share ontologies with SPINK13: view

No data available for Pathways by source and SIGNOR curated interactions for SPINK13 Gene

Drugs & Compounds for SPINK13 Gene

No Compound Related Data Available

Transcripts for SPINK13 Gene

mRNA/cDNA for SPINK13 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPINK13

Alternative Splicing Database (ASD) splice patterns (SP) for SPINK13 Gene

No ASD Table

Relevant External Links for SPINK13 Gene

GeneLoc Exon Structure for
SPINK13

Expression for SPINK13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPINK13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPINK13 Gene

This gene is overexpressed in Artery - Tibial (x4.3) and Artery - Coronary (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPINK13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPINK13

SOURCE GeneReport for Unigene cluster for SPINK13 Gene:

Hs.483771
genes like me logo Genes that share expression patterns with SPINK13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPINK13 Gene

Orthologs for SPINK13 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPINK13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SPINK13 30 31
  • 99.29 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Spink13 30 17 31
  • 70.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Spink13 30
  • 69.18 (n)
Species where no ortholog for SPINK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPINK13 Gene

ENSEMBL:
Gene Tree for SPINK13 (if available)
TreeFam:
Gene Tree for SPINK13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPINK13: view image

Paralogs for SPINK13 Gene

Paralogs for SPINK13 Gene

(5) SIMAP similar genes for SPINK13 Gene using alignment to 1 proteins:

  • ISK13_HUMAN
genes like me logo Genes that share paralogs with SPINK13: view

Variants for SPINK13 Gene

Additional dbSNP identifiers (rs#s) for SPINK13 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPINK13 Gene

Variant ID Type Subtype PubMed ID
dgv10111n54 CNV gain 21841781
dgv726n27 CNV gain 19166990
esv3607102 CNV loss 21293372
esv3607106 CNV loss 21293372
esv3607107 CNV gain 21293372
nsv599945 CNV loss 21841781

Variation tolerance for SPINK13 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPINK13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPINK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPINK13 Gene

Disorders for SPINK13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPINK13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
plasminogen deficiency, type i
  • dysplasminogenemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPINK13

genes like me logo Genes that share disorders with SPINK13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPINK13 Gene

Publications for SPINK13 Gene

  1. Novel urokinase-plasminogen activator inhibitor SPINK13 inhibits growth and metastasis of hepatocellular carcinoma in vivo. (PMID: 30862605) Wei L … Wang C (Pharmacological research 2019) 2 3
  2. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility. (PMID: 23430248) Ma L … Zhang Y (The Journal of biological chemistry 2013) 2 3
  3. The Role of Serine Peptidase Inhibitor Kazal Type 13 (SPINK13) as a Clinicopathological and Prognostic Biomarker in Patients with Clear Cell Renal Cell Carcinoma. (PMID: 31825950) Xu WH … Ye DW (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  4. Downregulation of SPINK13 Promotes Metastasis by Regulating uPA in Ovarian Cancer Cells. (PMID: 29439245) Cai S … Xu M (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3
  5. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li JY … Zhang YL (DNA research : an international journal for rapid publication of reports on genes and genomes 2008) 3

Products for SPINK13 Gene

Sources for SPINK13 Gene