Aliases for SPINK1 Gene
External Ids for SPINK1 Gene
Previous GeneCards Identifiers for SPINK1 Gene
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]
GeneCards Summary for SPINK1 Gene
SPINK1 (Serine Peptidase Inhibitor Kazal Type 1) is a Protein Coding gene. Diseases associated with SPINK1 include Pancreatitis, Hereditary and Tropical Calcific Pancreatitis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
UniProtKB/Swiss-Prot Summary for SPINK1 Gene
Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.