Aliases for SPINDOC Gene

Aliases for SPINDOC Gene

  • Spindlin Interactor And Repressor Of Chromatin Binding 2 3 5
  • SPIN-DOC 2 3 4
  • Spindlin Interactor And Repressor Of Chromatin-Binding Protein 3 4
  • C11orf84 3 4
  • Chromosome 11 Open Reading Frame 84 2
  • Uncharacterized Protein C11orf84 3
  • Hypothetical Protein BC007540 3
  • SPIN1 Docking Protein 3
  • SPIN1-Docking Protein 4
  • SPINDOC 5

External Ids for SPINDOC Gene

Previous HGNC Symbols for SPINDOC Gene

  • C11orf84

Summaries for SPINDOC Gene

GeneCards Summary for SPINDOC Gene

SPINDOC (Spindlin Interactor And Repressor Of Chromatin Binding) is a Protein Coding gene. Diseases associated with SPINDOC include Extraskeletal Chondroma and Chondroid Lipoma.

UniProtKB/Swiss-Prot Summary for SPINDOC Gene

  • Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SPINDOC Gene

Genomics for SPINDOC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SPINDOC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPINDOC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SPINDOC

Genomic Locations for SPINDOC Gene

Latest Assembly
chr11:63,813,374-63,827,718
(GRCh38/hg38)
Size:
14,345 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,580,928-63,595,188
(GRCh37/hg19 by Entrez Gene)
Size:
14,261 bases
Orientation:
Plus strand

chr11:63,580,860-63,595,190
(GRCh37/hg19 by Ensembl)
Size:
14,331 bases
Orientation:
Plus strand

Genomic View for SPINDOC Gene

Genes around SPINDOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINDOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINDOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINDOC Gene

Proteins for SPINDOC Gene

  • Protein details for SPINDOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUA3-SPNDC_HUMAN
    Recommended name:
    Spindlin interactor and repressor of chromatin-binding protein
    Protein Accession:
    Q9BUA3
    Secondary Accessions:
    • Q68CV7
    • Q6PHS2
    • Q96IH0

    Protein attributes for SPINDOC Gene

    Size:
    381 amino acids
    Molecular mass:
    41037 Da
    Quaternary structure:
    • Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Interacts with TCF7L2 in a SPIN1-dependent manner (PubMed:29061846).

neXtProt entry for SPINDOC Gene

Post-translational modifications for SPINDOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPINDOC Gene

Domains & Families for SPINDOC Gene

Gene Families for SPINDOC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPINDOC Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SPINDOC: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SPINDOC Gene

Function for SPINDOC Gene

Molecular function for SPINDOC Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).

Phenotypes From GWAS Catalog for SPINDOC Gene

Gene Ontology (GO) - Molecular Function for SPINDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29061846
genes like me logo Genes that share ontologies with SPINDOC: view
genes like me logo Genes that share phenotypes with SPINDOC: view

miRNA for SPINDOC Gene

miRTarBase miRNAs that target SPINDOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINDOC Gene

Localization for SPINDOC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPINDOC gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPINDOC Gene

Pathways & Interactions for SPINDOC Gene

PathCards logo

SuperPathways for SPINDOC Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPINDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IEA,IDA 29061846
genes like me logo Genes that share ontologies with SPINDOC: view

No data available for Pathways by source and SIGNOR curated interactions for SPINDOC Gene

Drugs & Compounds for SPINDOC Gene

No Compound Related Data Available

Transcripts for SPINDOC Gene

mRNA/cDNA for SPINDOC Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPINDOC Gene

No ASD Table

Relevant External Links for SPINDOC Gene

GeneLoc Exon Structure for
SPINDOC

Expression for SPINDOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SPINDOC

Evidence on tissue expression from TISSUES for SPINDOC Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPINDOC: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPINDOC Gene

Orthologs for SPINDOC Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINDOC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11H11orf84 30
  • 97.89 (n)
C11orf84 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C11orf84 31
  • 89 (a)
OneToOne
C18H11orf84 30
  • 88.07 (n)
Cow
(Bos Taurus)
Mammalia C29H11orf84 30 31
  • 85.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1308106 30
  • 82.12 (n)
Mouse
(Mus musculus)
Mammalia AI846148 30 31
  • 82.02 (n)
OneToOne
Spindoc 17
Oppossum
(Monodelphis domestica)
Mammalia C11orf84 31
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C11orf84 31
  • 48 (a)
OneToOne
Species where no ortholog for SPINDOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SPINDOC Gene

ENSEMBL:
Gene Tree for SPINDOC (if available)
TreeFam:
Gene Tree for SPINDOC (if available)

Paralogs for SPINDOC Gene

No data available for Paralogs for SPINDOC Gene

Variants for SPINDOC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SPINDOC Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs35875163 - p.Glu58Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SPINDOC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SPINDOC Gene

Variant ID Type Subtype PubMed ID
esv33730 CNV gain 17666407
nsv555180 CNV loss 21841781

Variation tolerance for SPINDOC Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPINDOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPINDOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPINDOC Gene

Disorders for SPINDOC Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPINDOC Gene - From: COP

Disorder Aliases PubMed IDs
extraskeletal chondroma
  • soft tissue chondroma
chondroid lipoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPINDOC

genes like me logo Genes that share disorders with SPINDOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPINDOC Gene

Publications for SPINDOC Gene

  1. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. (PMID: 29061846) Bae N … Bedford MT (The Journal of biological chemistry 2017) 2 3 4
  2. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for SPINDOC Gene

Sources for SPINDOC Gene