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Aliases for SPIN4 Gene

Aliases for SPIN4 Gene

  • Spindlin Family Member 4 2 3 5
  • Spindlin Family, Member 4 2
  • Spindlin-4 3
  • TDRD28 3

External Ids for SPIN4 Gene

Previous GeneCards Identifiers for SPIN4 Gene

  • GC0XM062484
  • GC0XM062568
  • GC0XM056393
  • GC0XM062569

Summaries for SPIN4 Gene

GeneCards Summary for SPIN4 Gene

SPIN4 (Spindlin Family Member 4) is a Protein Coding gene. An important paralog of this gene is SPIN2A.

UniProtKB/Swiss-Prot for SPIN4 Gene

  • Exhibits H3K4me3-binding activity.

Additional gene information for SPIN4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN4 Gene

Genomics for SPIN4 Gene

GeneHancer (GH) Regulatory Elements for SPIN4 Gene

Promoters and enhancers for SPIN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI063349 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.8 843 3 PKNOX1 ATF1 FOXA2 MLX SIN3A FEZF1 ZNF48 GLIS2 SP3 SP5 SPIN4 SPIN4-AS1 GC0XP063338 LINC01278
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPIN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPIN4 gene promoter:

Genomic Locations for SPIN4 Gene

Genomic Locations for SPIN4 Gene
4,117 bases
Minus strand

Genomic View for SPIN4 Gene

Genes around SPIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN4 Gene

Proteins for SPIN4 Gene

  • Protein details for SPIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KX90
    • Q5JUL2

    Protein attributes for SPIN4 Gene

    249 amino acids
    Molecular mass:
    28660 Da
    Quaternary structure:
    • Interacts with C11orf84/SPINDOC (PubMed:29061846).
    • Sequence=CAI41371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIN4 Gene

neXtProt entry for SPIN4 Gene

Post-translational modifications for SPIN4 Gene

  • Ubiquitination at posLast=5050
  • Modification sites at PhosphoSitePlus

Other Protein References for SPIN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIN4 Gene

Domains & Families for SPIN4 Gene

Gene Families for SPIN4 Gene

Protein Domains for SPIN4 Gene

Suggested Antigen Peptide Sequences for SPIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN4: view

Function for SPIN4 Gene

Molecular function for SPIN4 Gene

UniProtKB/Swiss-Prot Function:
Exhibits H3K4me3-binding activity.

Phenotypes From GWAS Catalog for SPIN4 Gene

Gene Ontology (GO) - Molecular Function for SPIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29061846
GO:0035064 methylated histone binding IDA 29061846
genes like me logo Genes that share ontologies with SPIN4: view

Phenotypes for SPIN4 Gene

genes like me logo Genes that share phenotypes with SPIN4: view

Animal Model Products

CRISPR Products

miRNA for SPIN4 Gene

miRTarBase miRNAs that target SPIN4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPIN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIN4 Gene

Localization for SPIN4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIN4 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPIN4 Gene

Pathways & Interactions for SPIN4 Gene

SuperPathways for SPIN4 Gene

No Data Available

Interacting Proteins for SPIN4 Gene

Gene Ontology (GO) - Biological Process for SPIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with SPIN4: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN4 Gene

Drugs & Compounds for SPIN4 Gene

No Compound Related Data Available

Transcripts for SPIN4 Gene

mRNA/cDNA for SPIN4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN4 Gene

Spindlin family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPIN4

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN4 Gene

No ASD Table

Relevant External Links for SPIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIN4 Gene

Protein differential expression in normal tissues from HIPED for SPIN4 Gene

This gene is overexpressed in Urinary Bladder (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPIN4 Gene

Protein tissue co-expression partners for SPIN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIN4 Gene:


SOURCE GeneReport for Unigene cluster for SPIN4 Gene:


Evidence on tissue expression from TISSUES for SPIN4 Gene

  • Nervous system(4.5)
  • Blood(3.6)
genes like me logo Genes that share expression patterns with SPIN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIN4 Gene

Orthologs for SPIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPIN4 33 34
  • 99.87 (n)
(Bos Taurus)
Mammalia SPIN4 33 34
  • 91.83 (n)
(Canis familiaris)
Mammalia SPIN4 33 34
  • 91.43 (n)
(Rattus norvegicus)
Mammalia Spin4 33
  • 89.83 (n)
(Mus musculus)
Mammalia Spin4 33 16 34
  • 88.62 (n)
(Ornithorhynchus anatinus)
Mammalia SPIN4 34
  • 55 (a)
(Danio rerio)
Actinopterygii SPIN4 (3 of 3) 34
  • 68 (a)
CABZ01112877.1 34
  • 54 (a)
SPIN4 (2 of 3) 34
  • 52 (a)
Species where no ortholog for SPIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIN4 Gene

Gene Tree for SPIN4 (if available)
Gene Tree for SPIN4 (if available)

Paralogs for SPIN4 Gene

Paralogs for SPIN4 Gene

(4) SIMAP similar genes for SPIN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN4: view

Variants for SPIN4 Gene

Sequence variations from dbSNP and Humsavar for SPIN4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1053713 -- 63,347,590(-) T/C 3_prime_UTR_variant
rs111287985 -- 63,347,451(-) T/C 3_prime_UTR_variant
rs111923761 -- 63,348,588(-) G/T 3_prime_UTR_variant
rs113579085 -- 63,352,061(-) A/G upstream_transcript_variant
rs12859290 -- 63,348,659(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SPIN4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354

Variation tolerance for SPIN4 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIN4 Gene

Disorders for SPIN4 Gene

Additional Disease Information for SPIN4

No disorders were found for SPIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN4 Gene

Publications for SPIN4 Gene

  1. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. (PMID: 29061846) Bae N … Bedford MT (The Journal of biological chemistry 2017) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58

Products for SPIN4 Gene

  • Addgene plasmids for SPIN4

Sources for SPIN4 Gene

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