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Aliases for SPIN2A Gene

Aliases for SPIN2A Gene

  • Spindlin Family Member 2A 2 3 5
  • Spindlin-Like Protein 2A 3 4
  • SPIN2 3 4
  • DXF34 3 4
  • Spindlin Family, Member 2A 2
  • Spindlin Family, Member 2 2
  • Spindlin-Like Protein 2 3
  • Centromeric Spin2 Copy 3
  • Spindlin Homolog 2 3
  • Protein DXF34 4
  • Spindlin-2A 3
  • DJ323P24.1 3
  • SPIN-2A 4
  • TDRD25 3
  • SPIN-2 4

External Ids for SPIN2A Gene

Previous HGNC Symbols for SPIN2A Gene

  • SPIN2

Previous GeneCards Identifiers for SPIN2A Gene

  • GC0XM057178
  • GC0XM054225

Summaries for SPIN2A Gene

Entrez Gene Summary for SPIN2A Gene

  • This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]

GeneCards Summary for SPIN2A Gene

SPIN2A (Spindlin Family Member 2A) is a Protein Coding gene. An important paralog of this gene is SPIN2B.

UniProtKB/Swiss-Prot for SPIN2A Gene

  • May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).

Additional gene information for SPIN2A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIN2A Gene

Genomics for SPIN2A Gene

GeneHancer (GH) Regulatory Elements for SPIN2A Gene

Promoters and enhancers for SPIN2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI057136 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.3 325 1.8 USF1 ZBTB33 SPIN2A UBQLN2 FAAH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPIN2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPIN2A gene promoter:

Genomic Locations for SPIN2A Gene

Genomic Locations for SPIN2A Gene
3,115 bases
Minus strand

Genomic View for SPIN2A Gene

Genes around SPIN2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIN2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIN2A Gene

Proteins for SPIN2A Gene

  • Protein details for SPIN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75650
    • Q6IPW2
    • Q9UJJ0

    Protein attributes for SPIN2A Gene

    258 amino acids
    Molecular mass:
    29188 Da
    Quaternary structure:
    • Interacts with C11orf84/SPINDOC (PubMed:29061846).
    • Sequence=CAA70988.1; Type=Frameshift; Positions=10; Evidence={ECO:0000305};

neXtProt entry for SPIN2A Gene

Post-translational modifications for SPIN2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPIN2A Gene

Domains & Families for SPIN2A Gene

Gene Families for SPIN2A Gene

Protein Domains for SPIN2A Gene

Suggested Antigen Peptide Sequences for SPIN2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPIN/STSY family.
  • Belongs to the SPIN/STSY family.
genes like me logo Genes that share domains with SPIN2A: view

Function for SPIN2A Gene

Molecular function for SPIN2A Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).

Gene Ontology (GO) - Molecular Function for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 29061846
GO:0035064 methylated histone binding IDA 29061846
genes like me logo Genes that share ontologies with SPIN2A: view
genes like me logo Genes that share phenotypes with SPIN2A: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPIN2A Gene

Localization for SPIN2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIN2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIN2A gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SPIN2A: view

Pathways & Interactions for SPIN2A Gene

SuperPathways for SPIN2A Gene

No Data Available

Interacting Proteins for SPIN2A Gene

Gene Ontology (GO) - Biological Process for SPIN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007276 gamete generation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with SPIN2A: view

No data available for Pathways by source and SIGNOR curated interactions for SPIN2A Gene

Drugs & Compounds for SPIN2A Gene

No Compound Related Data Available

Transcripts for SPIN2A Gene

mRNA/cDNA for SPIN2A Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIN2A Gene

Spindlin family, member 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIN2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SPIN2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPIN2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIN2A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPIN2A Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIN2A Gene:


SOURCE GeneReport for Unigene cluster for SPIN2A Gene:


Evidence on tissue expression from TISSUES for SPIN2A Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SPIN2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIN2A Gene

Orthologs for SPIN2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIN2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPIN2A 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
  • 87.6 (n)
-- 34
  • 85 (a)
(Rattus norvegicus)
Mammalia LOC367746 33
  • 81.6 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
(Mus musculus)
Mammalia Gm3757 33
  • 73.15 (n)
Gm2854 34
  • 64 (a)
Spin2d 34
  • 64 (a)
Spin2e 34
  • 63 (a)
Gm5926 34
  • 62 (a)
Spin2-ps5 34
  • 62 (a)
Spin2-ps6 34
  • 61 (a)
Spin2f 34
  • 61 (a)
(Gallus gallus)
Aves SPINZ 34
  • 77 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
Species where no ortholog for SPIN2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPIN2A Gene

Gene Tree for SPIN2A (if available)
Gene Tree for SPIN2A (if available)

Paralogs for SPIN2A Gene

Paralogs for SPIN2A Gene

(4) SIMAP similar genes for SPIN2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIN2A: view

Variants for SPIN2A Gene

Sequence variations from dbSNP and Humsavar for SPIN2A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002621421 -- 57,133,802(-) T/C downstream_transcript_variant
rs1002715603 -- 57,139,245(-) G/C upstream_transcript_variant
rs1003125649 -- 57,137,431(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1003198912 -- 57,138,645(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1003892517 -- 57,138,539(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Variation tolerance for SPIN2A Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPIN2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPIN2A Gene

Disorders for SPIN2A Gene

Additional Disease Information for SPIN2A

No disorders were found for SPIN2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIN2A Gene

Publications for SPIN2A Gene

  1. The structure of DXF34, a human X-linked sequence family with homology to a transcribed mouse Y-linked repeat. (PMID: 9271673) Laval SH … Boyd Y (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4 58
  2. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. (PMID: 29061846) Bae N … Bedford MT (The Journal of biological chemistry 2017) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for SPIN2A Gene

Sources for SPIN2A Gene

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