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Aliases for SPIC Gene

Aliases for SPIC Gene

  • Spi-C Transcription Factor 2 3 5
  • Spi-C Transcription Factor (Spi-1/PU.1 Related) 2 3
  • Transcription Factor Spi-C 3
  • SPI-C 3

External Ids for SPIC Gene

Previous GeneCards Identifiers for SPIC Gene

  • GC12P101853
  • GC12P100371
  • GC12P100393
  • GC12P101870
  • GC12P098930

Summaries for SPIC Gene

Entrez Gene Summary for SPIC Gene

  • The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

GeneCards Summary for SPIC Gene

SPIC (Spi-C Transcription Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SPIB.

UniProtKB/Swiss-Prot for SPIC Gene

  • Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Additional gene information for SPIC Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIC Gene

Genomics for SPIC Gene

GeneHancer (GH) Regulatory Elements for SPIC Gene

Promoters and enhancers for SPIC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I101475 Promoter 0.5 EPDnew 550.8 0.0 -6 0.1 SPIC RNA5SP367
GH12I101582 Enhancer 0.4 ENCODE dbSUPER 10.5 +108.5 108525 2.7 CHPT1 SPIC RNA5SP367 RNU5E-5P SYCP3 RNU6-101P MYBPC1 LOC105369938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPIC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPIC gene promoter:

Genomic Locations for SPIC Gene

Genomic Locations for SPIC Gene
chr12:101,475,323-101,487,566
(GRCh38/hg38)
Size:
12,244 bases
Orientation:
Plus strand
chr12:101,869,199-101,880,775
(GRCh37/hg19)

Genomic View for SPIC Gene

Genes around SPIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIC Gene

Proteins for SPIC Gene

  • Protein details for SPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5J4-SPIC_HUMAN
    Recommended name:
    Transcription factor Spi-C
    Protein Accession:
    Q8N5J4

    Protein attributes for SPIC Gene

    Size:
    248 amino acids
    Molecular mass:
    29180 Da
    Quaternary structure:
    • Binds DNA as a monomer.

neXtProt entry for SPIC Gene

Post-translational modifications for SPIC Gene

No Post-translational modifications

Other Protein References for SPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPIC Gene

Domains & Families for SPIC Gene

Gene Families for SPIC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SPIC Gene

Suggested Antigen Peptide Sequences for SPIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5J4

UniProtKB/Swiss-Prot:

SPIC_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with SPIC: view

Function for SPIC Gene

Molecular function for SPIC Gene

UniProtKB/Swiss-Prot Function:
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5-GAGGA[AT]-3) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Phenotypes From GWAS Catalog for SPIC Gene

Gene Ontology (GO) - Molecular Function for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with SPIC: view
genes like me logo Genes that share phenotypes with SPIC: view

Animal Models for SPIC Gene

MGI Knock Outs for SPIC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPIC Gene

Localization for SPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIC gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SPIC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPIC Gene

Pathways & Interactions for SPIC Gene

No Data Available

Interacting Proteins for SPIC Gene

Selected Interacting proteins: Q8N5J4-SPIC_HUMAN for SPIC Gene via IID

Gene Ontology (GO) - Biological Process for SPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with SPIC: view

No data available for Pathways by source and SIGNOR curated interactions for SPIC Gene

Drugs & Compounds for SPIC Gene

No Compound Related Data Available

Transcripts for SPIC Gene

mRNA/cDNA for SPIC Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPIC Gene

Spi-C transcription factor (Spi-1/PU.1 related):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIC Gene

No ASD Table

Relevant External Links for SPIC Gene

GeneLoc Exon Structure for
SPIC
ECgene alternative splicing isoforms for
SPIC

Expression for SPIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIC Gene

This gene is overexpressed in Spleen (x49.3).

Protein differential expression in normal tissues from HIPED for SPIC Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPIC Gene



Protein tissue co-expression partners for SPIC Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIC Gene:

SPIC

SOURCE GeneReport for Unigene cluster for SPIC Gene:

Hs.577097

mRNA Expression by UniProt/SwissProt for SPIC Gene:

Q8N5J4-SPIC_HUMAN
Tissue specificity: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver.

Evidence on tissue expression from TISSUES for SPIC Gene

  • Pancreas(4)
  • Spleen(2.5)
genes like me logo Genes that share expression patterns with SPIC: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIC Gene

Orthologs for SPIC Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIC 33 34
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia SPIC 33 34
  • 90.99 (n)
dog
(Canis familiaris)
Mammalia SPIC 33 34
  • 89.88 (n)
rat
(Rattus norvegicus)
Mammalia Spic 33
  • 80.35 (n)
mouse
(Mus musculus)
Mammalia Spic 33 16 34
  • 77.73 (n)
oppossum
(Monodelphis domestica)
Mammalia SPIC 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIC 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPIC 33 34
  • 70.57 (n)
lizard
(Anolis carolinensis)
Reptilia SPIC 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spic 33
  • 64.89 (n)
zebrafish
(Danio rerio)
Actinopterygii spic 33 34
  • 53.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
OneToMany
Species where no ortholog for SPIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIC Gene

ENSEMBL:
Gene Tree for SPIC (if available)
TreeFam:
Gene Tree for SPIC (if available)

Paralogs for SPIC Gene

Paralogs for SPIC Gene

(3) SIMAP similar genes for SPIC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPIC: view

Variants for SPIC Gene

Sequence variations from dbSNP and Humsavar for SPIC Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000266836 -- 101,478,343(+) TTTAATTTAATTT/TTTAATTT intron_variant
rs1000468963 -- 101,485,299(+) G/T intron_variant
rs1000496178 -- 101,480,449(+) T/C intron_variant
rs1000597179 -- 101,486,258(+) T/A/C intron_variant
rs1000632210 -- 101,480,182(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPIC Gene

Variant ID Type Subtype PubMed ID
nsv973109 CNV duplication 23825009
nsv507669 OTHER sequence alteration 20534489
nsv1113514 CNV deletion 24896259
dgv86e215 CNV deletion 23714750

Variation tolerance for SPIC Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIC Gene

Disorders for SPIC Gene

Additional Disease Information for SPIC

No disorders were found for SPIC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIC Gene

Publications for SPIC Gene

  1. Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C. (PMID: 12459275) Carlsson R … Leanderson T (Gene 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J … Thomson W (The pharmacogenomics journal 2014) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. SPI-C and STAT6 can cooperate to stimulate IgE germline transcription. (PMID: 16647686) Carlsson R … Leanderson T (Biochemical and biophysical research communications 2006) 3 58

Products for SPIC Gene

Sources for SPIC Gene

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