Aliases for SPI1 Gene
Aliases for SPI1 Gene
External Ids for SPI1 Gene
- HGNC: 11241
- Entrez Gene: 6688
- Ensembl: ENSG00000066336
- OMIM: 165170
- UniProtKB: P17947
Previous GeneCards Identifiers for SPI1 Gene
- GC11M049316
- GC11M048254
- GC11M047408
- GC11M047340
- GC11M047332
- GC11M047075
- GC11M047430
- GC11M048075
- GC11M048800
- GC11M049902
- GC11M047546
- GC11M047947
- GC11M050799
- GC11M051594
- GC11M052256
- GC11M052916
- GC11M053584
Summaries for SPI1 Gene
-
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPI1 Gene
SPI1 (Spi-1 Proto-Oncogene) is a Protein Coding gene. Diseases associated with SPI1 include Inflammatory Diarrhea and Neutrophil-Specific Granule Deficiency. Among its related pathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA binding. An important paralog of this gene is SPIB.
UniProtKB/Swiss-Prot for SPI1 Gene
-
Binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPI1 Gene
Genomics for SPI1 Gene
GeneHancer (GH) Regulatory Elements for SPI1 Gene
Promoters and enhancers for SPI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPI1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SPI1 gene promoter:
Regulatory Element Products
Genomic Locations for SPI1 Gene
Genomic Locations for SPI1 Gene
- chr11:47,354,858-47,395,640
- (GRCh38/hg38)
- Size:
- 40,783 bases
- Orientation:
- Minus strand
- chr11:47,376,409-47,400,127
- (GRCh37/hg19)
Genomic View for SPI1 Gene
Genes around SPI1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
SPI1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPI1 Gene
Proteins for SPI1 Gene
-
Protein details for SPI1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17947-SPI1_HUMAN
- Recommended name:
- Transcription factor PU.1
- Protein Accession:
- P17947
Protein attributes for SPI1 Gene
- Size:
- 270 amino acids
- Molecular mass:
- 31083 Da
- Quaternary structure:
-
- Binds DNA as a monomer. Interacts with CEBPD and NONO (By similarity). Interacts with RUNX1 and SPIB. Interacts with GFI1; the interaction represses SPI1 transcriptional activity. Interacts with CEBPE (PubMed:26019275).
- SequenceCaution:
-
- Sequence=CAA36281.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SPI1 Gene
Post-translational modifications for SPI1 Gene
Other Protein References for SPI1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SPI1 (PU.1/Spi-1)
-
Custom Antibody ServicesOriGene Antibodies for SPI1
- Novus Biologicals Antibodies for SPI1
-
Abcam antibodies for SPI1
- Invitrogen Antibodies for SPI1
- antibodies-online: Search results for 154 available SPI1 Antibodies ranked by validation data
- Compare Top SPI1 Antibodies
-
Recommended
- 1 IHC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 BCA Antibody (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 21 FACS Antibodies (anti-human)
- 103 WB Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 33 WB Antibodies (anti-mouse)
- GeneTex SPI1 antibody for SPI1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPI1
- Sino Biological Antibodies for SPI1
Protein Products
-
OriGene Purified Proteins for SPI1
- Search Origene for MassSpec and Protein Over-expression Lysates for SPI1
- Origene Custom Protein Services for SPI1
- ProSpec Recombinant Proteins for SPI1
- Search GeneTex for Proteins for SPI1
-
Abcam proteins for SPI1
Assay Products
No data available for DME Specific Peptides for SPI1 Gene
Domains & Families for SPI1 Gene
Gene Families for SPI1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transcription factors
Protein Domains for SPI1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPI1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17947- Family:
-
- Belongs to the ETS family.
Function for SPI1 Gene
Molecular function for SPI1 Gene
- GENATLAS Biochemistry:
- spleen focus forming virus (SFFV) proviral integration oncogene spi1,Pu-1 homolog,expressed in various hemapoietic cell lines,required for the development of both myeloid and lymphoid lineages
- UniProtKB/Swiss-Prot Function:
- Binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have undergone rearrangements of the SPI1 gene due to the insertion of SFFV. Negatively regulated by microRNA-155 (miR-155).
Phenotypes From GWAS Catalog for SPI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IEA | -- |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA,ISS | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
Phenotypes for SPI1 Gene
- MGI mutant phenotypes for SPI1:
-
inferred from 18 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for SPI1:
-
- Increased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Decreased POU5F1-GFP protein expression
- Increased shRNA abundance (Z-score > 2)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
Animal Models for SPI1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPI1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPI1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPI1 gene
- Search ViGene Biosciences for SPI1
CRISPR Products
-
OriGene CRISPR knockouts for SPI1
- genomics-online: gRNA clones - Search results for available SPI1 gene related products
- Applied Biological Materials CRISPR for SPI1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPI1
- GenScript: Design CRISPR guide RNA sequences for SPI1
miRNA for SPI1 Gene
- miRTarBase miRNAs that target SPI1
-
- hsa-mir-155-5p (MIRT004282)
- hsa-mir-569 (MIRT004827)
- hsa-mir-34a-5p (MIRT005724)
- hsa-mir-424-5p (MIRT005928)
- hsa-mir-9-5p (MIRT021410)
- hsa-mir-296-3p (MIRT038360)
- bta-mir-155 (MIRT053953)
- hsa-mir-6845-3p (MIRT625713)
- hsa-mir-6749-3p (MIRT625714)
- hsa-mir-4669 (MIRT625715)
- hsa-mir-3657 (MIRT625716)
- hsa-mir-6090 (MIRT625717)
- hsa-mir-7113-3p (MIRT625718)
- hsa-mir-339-5p (MIRT625719)
- hsa-mir-1247-3p (MIRT625720)
- hsa-mir-5587-3p (MIRT625721)
Targeted motifs for SPI1 Gene
HOMER Transcription Factor Regulatory Elements motif SPI1
- Consensus sequence: AGAGGAAGTG Submotif: canonical Cell Type: ThioMac GEO ID: GSE21512
miRNA Products
- Search ViGene Biosciences for SPI1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPI1
- Browse OriGene Inhibitory RNA Products For SPI1
- genomics-online: shRNA clones - Search results for available SPI1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPI1 gene
Clone Products
- Sino Biological Human cDNA Clone for SPI1
- VectorBuilder custom plasmid, inducible vectors for SPI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPI1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPI1 gene related products
- orf clones - Search results for available SPI1 gene related products
- Applied Biological Materials Clones for SPI1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPI1
-
ViGene Biosciences adenoviral particle packaged cDNA for SPI1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPI1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPI1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for SPI1 Gene
Localization for SPI1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPI1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA,IDA | 15304486 |
| GO:0005634 | nucleus | IEA,IDA | 20972335 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SPI1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endometrial cancer | ||
| 2 | Epstein-Barr virus infection | ||
| 3 | HTLV-I infection | ||
| 4 | Osteoclast differentiation | ||
| 5 | Pathways in cancer | ||
Pathways by source for SPI1 Gene
9 BioSystems pathways for SPI1 Gene
6 KEGG pathways for SPI1 Gene
1 GeneGo (Thomson Reuters) pathway for SPI1 Gene
2 R&D Systems pathways for SPI1 Gene
1 Cell Signaling Technology pathway for SPI1 Gene
Interacting Proteins for SPI1 Gene
Selected Interacting proteins:
ENSP00000227163
P17947-SPI1_HUMAN
for SPI1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001944 | vasculature development | IEA | -- |
| GO:0002320 | lymphoid progenitor cell differentiation | IEA | -- |
| GO:0002573 | myeloid leukocyte differentiation | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for SPI1 Gene
Transcripts for SPI1 Gene
mRNA/cDNA for SPI1 Gene
- (4) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (114) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPI1 Gene
- Spleen focus forming virus (SFFV) proviral integration oncogene spi1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SPI1
- genomics-online: gRNA clones - Search results for available SPI1 gene related products
- Applied Biological Materials CRISPR for SPI1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPI1
- GenScript: Design CRISPR guide RNA sequences for SPI1
miRNA Products
- Search ViGene Biosciences for SPI1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPI1
- Browse OriGene Inhibitory RNA Products For SPI1
- genomics-online: shRNA clones - Search results for available SPI1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPI1 gene
Clone Products
- Sino Biological Human cDNA Clone for SPI1
- VectorBuilder custom plasmid, inducible vectors for SPI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPI1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPI1 gene related products
- orf clones - Search results for available SPI1 gene related products
- Applied Biological Materials Clones for SPI1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - |
Expression for SPI1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Pro B-Cells Hematopoietic Bone Marrow
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
- Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
-
Kidney (Urinary System)
- Metanephros
- Interstitial Stroma
- Glomerular Tuft
- Glomerulus
- Medullary Stroma Cells Interstitial Stroma
-
Bone (Muscoskeletal System)
- Bone Marrow
- Mononucleated Osteoclasts Bone Marrow
- Osteoclast Precursor Cells Hematopoietic Bone Marrow
-
Lung (Respiratory System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SPI1 Gene
This gene is overexpressed in Whole Blood (x39.7).
This gene is overexpressed in Monocytes (25.8), Blymphocyte (24.0), and Pancreas (12.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPI1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SPI1 Gene:
SPI1SOURCE GeneReport for Unigene cluster for SPI1 Gene:
Hs.502511Evidence on tissue expression from TISSUES for SPI1 Gene
- Liver(4.4)
- Blood(3.3)
- Bone marrow(3.3)
- Spleen(3.1)
- Intestine(2.9)
- Lymph node(2.9)
- Lung(2.5)
Primer Products
-
OriGene qPCR primer pairs for SPI1
-
OriGene qPCR primer pairs and template standards for SPI1
- genomics-online: primer clones - Search results for available SPI1 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPI1 Gene
Orthologs for SPI1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SPI1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SPI1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Spi1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Spi1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPI1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPI1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | SPI1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPI1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SPI1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | spi1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | spi1b 33 34 |
|
||
| spi1 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10886 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SPI1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPI1 Gene
(2) SIMAP similar genes for SPI1 Gene using alignment to 3 proteins:
Variants for SPI1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000024728 | -- | 47,397,627(-) | A/G | upstream_transcript_variant | |
| rs1000055357 | -- | 47,372,801(-) | C/G | intron_variant | |
| rs1000118259 | -- | 47,391,929(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000303349 | -- | 47,356,961(-) | T/C | intron_variant | |
| rs1000342945 | -- | 47,397,318(-) | T/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv622e59 | CNV | duplication | 20981092 |
| esv275512 | CNV | loss | 21479260 |
| esv3439899 | CNV | duplication | 20981092 |
| esv992404 | CNV | insertion | 20482838 |
| nsv1075832 | CNV | duplication | 25765185 |
| nsv1127180 | CNV | deletion | 24896259 |
| nsv1132343 | CNV | duplication | 24896259 |
| nsv1134113 | CNV | deletion | 24896259 |
| nsv1141192 | CNV | duplication | 24896259 |
| nsv509404 | CNV | insertion | 20534489 |
| nsv513315 | CNV | insertion | 21212237 |
| nsv554210 | CNV | loss | 21841781 |
| nsv825871 | CNV | gain | 20364138 |
| nsv832141 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.34;
26.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPI1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPI1 Gene
Disorders for SPI1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory diarrhea |
|
|
| neutrophil-specific granule deficiency |
|
|
| acute erythroid leukemia |
|
|
| interdigitating dendritic cell sarcoma |
|
|
| parotid gland cancer |
|
|
Search SPI1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SPI1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SPI1 Gene
Publications for SPI1 Gene
- The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. (PMID: 1693183) Ray D … Moreau-Gachelin F (Oncogene 1990) 2 3 4 22 58
- A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. (PMID: 26019275) Wada T … Yachie A (Journal of immunology (Baltimore, Md. : 1950) 2015) 3 4 58
- Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. (PMID: 19747912) Brugnoli F … Bertagnolo V (Experimental cell research 2010) 3 22 58
- Heterozygous deletion of the PU.1 locus in human AML. (PMID: 19890096) Bonadies N … Mueller BU (Blood 2010) 3 44 58
- Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins. (PMID: 18692240) Yamada T … Tsuchida S (Leukemia research 2009) 3 22 58
Products for SPI1 Gene
- R&D Systems Antibodies for SPI1 (PU.1/Spi-1)
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- Custom Antibody ServicesOriGene Antibodies for SPI1
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- OriGene qPCR primer pairs and template standards for SPI1
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- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for SPI1
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPI1
- VectorBuilder custom plasmid, inducible vectors for SPI1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPI1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 154 available SPI1 Antibodies ranked by validation data
- Compare Top SPI1 Antibodies
- Recommended
- 33 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 103 WB Antibodies (anti-human)
- 21 FACS Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- antibodies-online: Search results for 9 available SPI1 Elisa Kits ranked by validation data
- Compare Top SPI1 Elisa Kits
- antibodies-online: Search results for 12 available SPI1 Proteins ranked by validation data
- Compare Top SPI1 Proteins
- GeneTex SPI1 antibody for SPI1
- Search GeneTex for Proteins for SPI1
- ViGene Biosciences adenoviral particle packaged cDNA for SPI1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPI1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPI1 gene
- Search ViGene Biosciences for SPI1
- Santa Cruz Biotechnology (SCBT) Antibodies for SPI1
- Search Santa Cruz Biotechnology (SCBT) for SPI1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPI1
- Horizon Cell Lines for SPI1
- genomics-online: cdna clones - Search results for available SPI1 gene related products
- orf clones - Search results for available SPI1 gene related products
- genomics-online: gRNA clones - Search results for available SPI1 gene related products
- genomics-online: primer clones - Search results for available SPI1 gene related products
- genomics-online: shRNA clones - Search results for available SPI1 gene related products
Sources for SPI1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems